Seroatlas · Human Serome Atlas

LRRIQ1

Leucine-rich repeat- and IQ domain-containing protein 1

Also known as: FLJ12303, KIAA1801, LRIQ1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q96JM4
Gene: LRRIQ1
Ensembl: ENSG00000133640
Chromosome: 12
Canonical length: 1722 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

Predicted to be involved in regulation of signal transduction. Predicted to be active in microtubule cytoskeleton. [provided by Alliance of Genome Resources, Apr 2025]

Canonical amino-acid sequenceUniProt

1722 residues, UniProt reviewed canonical sequence.

>Q96JM4|LRRIQ1
     1  MDDDDAKLKA EIEAELDKLS ISSLEKEDIE SDAKSETQSD DSDTDSVELP ESVLHCINII
    61  KNRSKAVEEL ILQDLEDTDI LSCSYGAVSN NHMHLRTGLS TEYEESSEQL IKILSEIEKE
   121  EFMRSKTDCA TPDFVPEPSP HDLPMDEHVL PDDADINFGY CEVEEKCRQS FEAWQEKQKE
   181  LEDKEKQTLK AQRDREEKQF QEEEEKRHCW MKQFKVEKKK LENIQKQEQD KMNDELYKEE
   241  KIWKEKFKQH EEYIRNLHLQ MEEERTRFKD QQEKEKNSLL KQQNNAAVKI QAKYKAFVAY
   301  QKYGPIIKEQ IESKKRKAQE WKEKEAKIRQ KEEENRKRLE EEQRIKEERK KQKEEERKRR
   361  EKEYEEKKNI VKQEREQLIS KEKIILREDA SQQLIISSAL KKSGYNNKHL SLEDISNDKG
   421  DIAKNLVDEN SKKQEDVLLW LVEESNMKEN VDRQTILKES IQVKLKESIS SQTILADFKM
   481  EEKNENLAKK RCSEELVKQE RKYENTDNKT ELGNSDLKGN LKEQFPLQEL KSDAQKEEKI
   541  MKHVINENTG QKTQIILGHN QEISEVKTNE EQKIIKDNQQ KKIQKVEKEE IQEQNGLLYK
   601  DKDTLVISVK QRSLSLTSEN SKDVRENVIL QEKEIYSKSK EIEENPKDNA WNSGIVIFNT
   661  TDTMINIEGK RNDQDYVLGR HAPCEGLSNY NAESSMVSKE VNSLKSEIRN ISEKCHENAP
   721  EPDSMTCCVS ESTLLYSIEE RRLAWIKSFK PWLEIFKQNQ QKKIVRRKRP VKCPANMTPA
   781  LDKLEILRCG PWDTLQQVTT VTFQDLPGCV LSTLAECTNL QFLSLRRCGL TSLHSLSNCK
   841  KLKYIDAQEN HIEAIECENL ENLCVVLLNK NQLTSLHGLD GCTNIQCLEL SYNKITRIGY
   901  SFFLEEKLVD NAGFCHHLGT STSYLSLAQV WIPTGLCWSW IPITSLTKNS DCNFLISHLY
   961  WNCGLESLKN LQQLILDHNQ LINTKGLCDT PTIVYLDCSH NHLTDVEGVE NCGLLQILKL
  1021  QGNYLSELPS LENLVLLREL HLDDNSISTV EAFSSYWLPL LQNITISQNS LTKIVPLFHF
  1081  VSLEKLDVSH NCLSDLKSAI KWFDACYSLH ELSLTGNPLL QETNWRDSLL KVLPALRILN
  1141  GNILNSNSES RTEEHNQLGS AGFLALCQSQ IREFNLLIEN YITGKGDVFT LDTAENLCHY
  1201  FKKLMILSTE YRHAHERGDV TITKKDESEA QKNHLAPTNS DSTLQNGVFY SCAREGEPDS
  1261  PDIPEKWMDS VSSHSPLSKS ATCENMEGRH QEILVCQKRE DSKASSIPTI RIPFKEVVMT
  1321  NSLLRNHQNI EPSEKIMAAV VIQSYWRGYL MRRQTHFSTR LHTAATEGLP NSSIKNQTIL
  1381  KKGKRENIVN IRKQREKAAI LIQAVWKGFI LRKKLTTALE AIKNEESDEE YREIDLEDFI
  1441  FDEAALEEEW LALDSTRFPS QTLLLSNQLH WPKIPGNLKW DDTSFNLPSN PAQAWLCNDK
  1501  ENLSSSEHTQ FNSRSENKTS SWTPESKTSR KSLLKSEKEK KISEEWGFKD ISTAQQMLKR
  1561  AQKMKSKKLK KKIDSTVRLA LFKNNENKVS LPKSPKMVQP RRDGYFEGIE EDPIHKDTTA
  1621  NEKLERNREY TYQWLHTQVG VHETTSSRNM KCNHFLPELD PDVLNGGRVQ LVARLVSRED
  1681  TDLDLFSMTN GSALSVNREK KNQAHRHSAG SSSKLWFPSK LI

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against LRRIQ1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.54
Highest tissue expression: 15 nTPM

Expression across tissuesHPA

Tissue

testis: 15 nTPM
choroid plexus: 13 nTPM
fallopian tube: 13 nTPM
retina: 8.1 nTPM
hypothalamus: 3.7 nTPM
hippocampal formation: 3.1 nTPM

Single-cell type

respiratory ciliated cells: 1,857 nCPM
ependymal cells: 1,461 nCPM
epididymal efferent duct ciliated cells: 859 nCPM
fallopian tube ciliated cells: 821 nCPM
endometrial ciliated cells: 672 nCPM
choroid plexus epithelial cells: 611 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

choroid plexus: 36 nTPM
medulla oblongata: 24 nTPM
midbrain: 17 nTPM
spinal cord: 13 nTPM
white matter: 7 nTPM
hypothalamus: 6.8 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.94
gnomAD pLI: 0
gnomAD missense Z: -1.09
DepMap mean gene effect: -0.01
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

microtubule cytoskeleton

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads LRRIQ1 as an antibody target. Whether an autoantibody or antibody against LRRIQ1 could matter depends on whether native LRRIQ1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

LRRIQ1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label LRRIQ1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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