Seroatlas · Human Serome Atlas

EIF2S3B

Eukaryotic translation initiation factor 2 subunit 3B

Also known as: eIF-2-gamma2, eIF2gA, IF2GL_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q2VIR3
Gene: EIF2S3B
Ensembl: ENSG00000180574
Chromosome: 12
Canonical length: 472 aa
Protein class: Enzymes, Predicted intracellular proteins

OverviewNCBI Gene

Predicted to enable translation initiation factor activity. Predicted to contribute to tRNA binding activity. Predicted to be involved in formation of translation preinitiation complex. Predicted to act upstream of or within positive regulation of male gonad development and spermatogenesis. Predicted to be part of eukaryotic translation initiation factor 2 complex. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

472 residues, UniProt reviewed canonical sequence.

>Q2VIR3|EIF2S3B
     1  MAGGEAGVTL GQPHLSRQDL TTLDVTKLTP LSHEVISRQA TINIGTIGHV AHGKSTVVKA
    61  ISGVHTVRFK NELERNITIK LGYANAKIYQ LDDPSCPRPE CYRSCGSSMP DEFPTDIPGT
   121  KGNFRLVRHV SFVDCPGHDI LMATMLNGAA VMDAALLLIA GNESCPQPQT SEHLAAIEIM
   181  KLKHILILQN KIDLVKERQA KEQYEQILAF VQGTVAEGAP IIPISAQLKY NIEVVCEYIV
   241  KKIPVPPRDF TSEPRLIVIR SFDVNKPGCE VDDLKGGVAG GSILKGVLKV GQETEVRPGI
   301  VSKDSEGKLM CKSIFSKIVS LFAEHNDLQY AAPGGLIGVG TKIDPTLCRA DRMVGQILGA
   361  VGALPEIFTE LEISYFLLRR LLGVRTEGDK KAAKVQKLSK NEVLMVNIGS LSTGGRVSAV
   421  KADLGKIVLT NPVCTEVGEK IALSRRVEKH WRLIGWGQIR RGVTIKPTVD DD

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against EIF2S3B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.25
Highest tissue expression: 1.7 nTPM

Expression across tissuesHPA

Tissue

testis: 1.7 nTPM
ovary: 1 nTPM
cervix: 0.8 nTPM
pancreas: 0.8 nTPM
blood vessel: 0.7 nTPM
colon: 0.7 nTPM

Single-cell type

early primary spermatocytes: 14 nCPM
goblet cells: 12 nCPM
late primary spermatocytes: 9.5 nCPM
early spermatids: 8.6 nCPM
undifferentiated spermatogonia: 8.4 nCPM
differentiating spermatogonia: 7.1 nCPM

Immune cell

naive CD8 T-cell: 0.5 nTPM
intermediate monocyte: 0.3 nTPM
MAIT T-cell: 0.3 nTPM
memory B-cell: 0.3 nTPM
memory CD8 T-cell: 0.3 nTPM
naive CD4 T-cell: 0.3 nTPM

Brain region

cerebellum: 1.4 nTPM
white matter: 1.3 nTPM
basal ganglia: 1 nTPM
cerebral cortex: 1 nTPM
choroid plexus: 1 nTPM
pons: 1 nTPM

OntologyGO

Biological processes

formation of translation preinitiation complex

Molecular functions

Cellular components

eukaryotic translation initiation factor 2 complex

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads EIF2S3B as an antibody target. Whether an autoantibody or antibody against EIF2S3B could matter depends on whether native EIF2S3B is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

EIF2S3B is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label EIF2S3B as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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