Seroatlas · Human Serome Atlas

MPP1

55 kDa erythrocyte membrane protein

Also known as: DXS552E, EM55_HUMAN, PEMP

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q00013
Gene: MPP1
Ensembl: ENSG00000130830
Chromosome: X
Canonical length: 466 aa
Protein class: Predicted intracellular proteins
Subcellular location: Plasma membrane,Centriolar satellite

OverviewNCBI Gene

This gene encodes the prototype of the membrane-associated guanylate kinase (MAGUK) family proteins. MAGUKs interact with the cytoskeleton and regulate cell proliferation, signaling pathways, and intercellular junctions. The encoded protein is an extensively palmitoylated membrane phosphoprotein containing a PDZ domain, a Src homology 3 (SH3) motif, and a guanylate kinase domain. This gene product interacts with various cytoskeletal proteins and cell junctional proteins in different tissue and cell types, and may be involved in the regulation of cell shape, hair cell development, neural patterning of the retina, and apico-basal polarity and tumor suppression pathways in non-erythroid cells. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2009]

Canonical amino-acid sequenceUniProt

466 residues, UniProt reviewed canonical sequence.

>Q00013|MPP1
     1  MTLKASEGES GGSMHTALSD LYLEHLLQKR SRPEAVSHPL NTVTEDMYTN GSPAPGSPAQ
    61  VKGQEVRKVR LIQFEKVTEE PMGITLKLNE KQSCTVARIL HGGMIHRQGS LHVGDEILEI
   121  NGTNVTNHSV DQLQKAMKET KGMISLKVIP NQQSRLPALQ MFMRAQFDYD PKKDNLIPCK
   181  EAGLKFATGD IIQIINKDDS NWWQGRVEGS SKESAGLIPS PELQEWRVAS MAQSAPSEAP
   241  SCSPFGKKKK YKDKYLAKHS SIFDQLDVVS YEEVVRLPAF KRKTLVLIGA SGVGRSHIKN
   301  ALLSQNPEKF VYPVPYTTRP PRKSEEDGKE YHFISTEEMT RNISANEFLE FGSYQGNMFG
   361  TKFETVHQIH KQNKIAILDI EPQTLKIVRT AELSPFIVFI APTDQGTQTE ALQQLQKDSE
   421  AIRSQYAHYF DLSLVNNGVD ETLKKLQEAF DQACSSPQWV PVSWVY

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MPP1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.36
Highest tissue expression: 110 nTPM

Expression across tissuesHPA

Tissue

bone marrow: 110 nTPM
placenta: 81 nTPM
thymus: 68 nTPM
duodenum: 56 nTPM
small intestine: 45 nTPM
spleen: 40 nTPM

Single-cell type

platelets: 1,826 nCPM
cytotrophoblasts: 528 nCPM
syncytiotrophoblasts: 518 nCPM
megakaryocytes: 464 nCPM
hofbauer cells: 412 nCPM
erythrocytes: 306 nCPM

Immune cell

eosinophil: 216 nTPM
neutrophil: 203 nTPM
non-classical monocyte: 99 nTPM
classical monocyte: 96 nTPM
total PBMC: 79 nTPM
intermediate monocyte: 77 nTPM

Brain region

pons: 45 nTPM
cerebral cortex: 42 nTPM
white matter: 41 nTPM
thalamus: 40 nTPM
cerebellum: 36 nTPM
hypothalamus: 34 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.27
gnomAD pLI: 0.99
gnomAD missense Z: 1.67
DepMap mean gene effect: 0.01
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of MPP1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MPP1 as an antibody target. Whether an autoantibody or antibody against MPP1 could matter depends on whether native MPP1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MPP1 is annotated at the cell surface, where native MPP1 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label MPP1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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