Seroatlas · Human Serome Atlas

SULT1E1

Sulfotransferase 1E1

Also known as: EST, ST1E1_HUMAN, STE

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P49888
Gene: SULT1E1
Ensembl: ENSG00000109193
Chromosome: 4
Canonical length: 294 aa
Protein class: Cancer-related genes, Enzymes, Metabolic proteins, Predicted intracellular proteins
Subcellular location: Nuclear membrane,Cytosol
Quaternary structure: Homodimer

OverviewNCBI Gene

Sulfotransferase enzymes catalyze the sulfate conjugation of many hormones, neurotransmitters, drugs, and xenobiotic compounds. These cytosolic enzymes are different in their tissue distributions and substrate specificities. The gene structure (number and length of exons) is similar among family members. This gene encodes a protein that transfers a sulfo moiety to and from estrone, which may control levels of estrogen receptors. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

294 residues, UniProt reviewed canonical sequence.

>P49888|SULT1E1
     1  MNSELDYYEK FEEVHGILMY KDFVKYWDNV EAFQARPDDL VIATYPKSGT TWVSEIVYMI
    61  YKEGDVEKCK EDVIFNRIPF LECRKENLMN GVKQLDEMNS PRIVKTHLPP ELLPASFWEK
   121  DCKIIYLCRN AKDVAVSFYY FFLMVAGHPN PGSFPEFVEK FMQGQVPYGS WYKHVKSWWE
   181  KGKSPRVLFL FYEDLKEDIR KEVIKLIHFL ERKPSEELVD RIIHHTSFQE MKNNPSTNYT
   241  TLPDEIMNQK LSPFMRKGIT GDWKNHFTVA LNEKFDKHYE QQMKESTLKF RTEI

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SULT1E1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.23
Highest tissue expression: 35 nTPM

Expression across tissuesHPA

Tissue

liver: 35 nTPM
vagina: 29 nTPM
duodenum: 26 nTPM
small intestine: 26 nTPM
skin: 18 nTPM
cervix: 17 nTPM

Single-cell type

conjunctival goblet cells: 140 nCPM
endometrial ciliated cells: 101 nCPM
respiratory basal cells: 51 nCPM
enterocytes: 49 nCPM
endometrial luminal cells: 45 nCPM
salivary basal cells: 25 nCPM

Immune cell

neutrophil: 0.2 nTPM
basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM

Brain region

choroid plexus: 9.5 nTPM
white matter: 1.1 nTPM
cerebral cortex: 1 nTPM
midbrain: 1 nTPM
pons: 1 nTPM
thalamus: 1 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.27
gnomAD pLI: 0
gnomAD missense Z: 0.12
DepMap mean gene effect: 0.01
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SULT1E1 as an antibody target. Whether an autoantibody or antibody against SULT1E1 could matter depends on whether native SULT1E1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SULT1E1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SULT1E1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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