Seroatlas · Human Serome Atlas

DLG1

Disks large homolog 1

Also known as: dJ1061C18.1.1, DLG1_HUMAN, DLGH1, hdlg, SAP-97, SAP97

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q12959
Gene
DLG1
Ensembl
ENSG00000075711
Chromosome
3
Canonical length
904 aa
Protein class
Predicted intracellular proteins, Transporters
Subcellular location
Vesicles,Plasma membrane,Basal body
Quaternary structure
Homotetramer

OverviewNCBI Gene

This gene encodes a multi-domain scaffolding protein that is required for normal development. This protein may have a role in septate junction formation, signal transduction, cell proliferation, synaptogenesis and lymphocyte activation. A multitude of transcript variants deriving from alternative splicing and the use of multiple alternate promoter have been observed, including some splice variants that may be specific to brain and other tissues. An upstream uORF may regulate translation at some splice variants of this gene. [provided by RefSeq, Sep 2018]

Canonical amino-acid sequenceUniProt

904 residues, UniProt reviewed canonical sequence.

>Q12959|DLG1
     1  MPVRKQDTQR ALHLLEEYRS KLSQTEDRQL RSSIERVINI FQSNLFQALI DIQEFYEVTL
    61  LDNPKCIDRS KPSEPIQPVN TWEISSLPSS TVTSETLPSS LSPSVEKYRY QDEDTPPQEH
   121  ISPQITNEVI GPELVHVSEK NLSEIENVHG FVSHSHISPI KPTEAVLPSP PTVPVIPVLP
   181  VPAENTVILP TIPQANPPPV LVNTDSLETP TYVNGTDADY EYEEITLERG NSGLGFSIAG
   241  GTDNPHIGDD SSIFITKIIT GGAAAQDGRL RVNDCILRVN EVDVRDVTHS KAVEALKEAG
   301  SIVRLYVKRR KPVSEKIMEI KLIKGPKGLG FSIAGGVGNQ HIPGDNSIYV TKIIEGGAAH
   361  KDGKLQIGDK LLAVNNVCLE EVTHEEAVTA LKNTSDFVYL KVAKPTSMYM NDGYAPPDIT
   421  NSSSQPVDNH VSPSSFLGQT PASPARYSPV SKAVLGDDEI TREPRKVVLH RGSTGLGFNI
   481  VGGEDGEGIF ISFILAGGPA DLSGELRKGD RIISVNSVDL RAASHEQAAA ALKNAGQAVT
   541  IVAQYRPEEY SRFEAKIHDL REQMMNSSIS SGSGSLRTSQ KRSLYVRALF DYDKTKDSGL
   601  PSQGLNFKFG DILHVINASD DEWWQARQVT PDGESDEVGV IPSKRRVEKK ERARLKTVKF
   661  NSKTRDKGEI PDDMGSKGLK HVTSNASDSE SSYRGQEEYV LSYEPVNQQE VNYTRPVIIL
   721  GPMKDRINDD LISEFPDKFG SCVPHTTRPK RDYEVDGRDY HFVTSREQME KDIQEHKFIE
   781  AGQYNNHLYG TSVQSVREVA EKGKHCILDV SGNAIKRLQI AQLYPISIFI KPKSMENIME
   841  MNKRLTEEQA RKTFERAMKL EQEFTEHFTA IVQGDTLEDI YNQVKQIIEE QSGSYIWVPA
   901  KEKL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against DLG1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.42
Highest tissue expression
41 nTPM

Expression across tissuesHPA

Tissue

  • thyroid gland: 41 nTPM
  • retina: 36 nTPM
  • esophagus: 35 nTPM
  • spinal cord: 35 nTPM
  • parathyroid gland: 30 nTPM
  • amygdala: 29 nTPM

Single-cell type

  • oligodendrocytes: 2,027 nCPM
  • endometrial secretory cells: 724 nCPM
  • esophageal apical cells: 632 nCPM
  • ocular epithelial cells: 583 nCPM
  • esophageal suprabasal cells: 527 nCPM
  • suprabasal keratinocytes: 453 nCPM

Immune cell

  • basophil: 2.3 nTPM
  • neutrophil: 2.2 nTPM
  • memory B-cell: 1.5 nTPM
  • MAIT T-cell: 1.3 nTPM
  • eosinophil: 1.2 nTPM
  • memory CD4 T-cell: 1.2 nTPM

Brain region

  • white matter: 185 nTPM
  • basal ganglia: 151 nTPM
  • thalamus: 138 nTPM
  • midbrain: 125 nTPM
  • medulla oblongata: 113 nTPM
  • pons: 108 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.29
gnomAD pLI
0.99
gnomAD missense Z
1.5
DepMap mean gene effect
0.12
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 13% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of DLG1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads DLG1 as an antibody target. Whether an autoantibody or antibody against DLG1 could matter depends on whether native DLG1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

DLG1 is annotated at the cell surface, where native DLG1 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label DLG1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/DLG1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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