Seroatlas · Human Serome Atlas

GIMAP5

GTPase IMAP family member 5

Also known as: GIMA5_HUMAN, HIMAP3, IAN4L1, IAN5

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q96F15
Gene: GIMAP5
Ensembl: ENSG00000196329
Chromosome: 7
Canonical length: 307 aa
Protein class: Disease related genes, Predicted membrane proteins

OverviewNCBI Gene

This gene encodes a protein belonging to the GTP-binding superfamily and to the immuno-associated nucleotide (IAN) subfamily of nucleotide-binding proteins. In humans, the IAN subfamily genes are located in a cluster at 7q36.1. This gene encodes an antiapoptotic protein that functions in T-cell survival. Polymorphisms in this gene are associated with systemic lupus erythematosus. Read-through transcription exists between this gene and the neighboring upstream GIMAP1 (GTPase, IMAP family member 1) gene. [provided by RefSeq, Dec 2010]

Canonical amino-acid sequenceUniProt

307 residues, UniProt reviewed canonical sequence.

>Q96F15|GIMAP5
     1  MGGFQRGKYG TMAEGRSEDN LSATPPALRI ILVGKTGCGK SATGNSILGQ PVFESKLRAQ
    61  SVTRTCQVKT GTWNGRKVLV VDTPSIFESQ ADTQELYKNI GDCYLLSAPG PHVLLLVIQL
   121  GRFTAQDTVA IRKVKEVFGT GAMRHVVILF THKEDLGGQA LDDYVANTDN CSLKDLVREC
   181  ERRYCAFNNW GSVEEQRQQQ AELLAVIERL GREREGSFHS NDLFLDAQLL QRTGAGACQE
   241  DYRQYQAKVE WQVEKHKQEL RENESNWAYK ALLRVKHLML LHYEIFVFLL LCSILFFIIF
   301  LFIFHYI

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against GIMAP5 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.33
Highest tissue expression: 100 nTPM

Expression across tissuesHPA

Tissue

lymph node: 100 nTPM
spleen: 65 nTPM
tonsil: 62 nTPM
lung: 58 nTPM
adipose tissue: 48 nTPM
appendix: 42 nTPM

Single-cell type

microglia: 21 nCPM
vascular endothelial cells: 11 nCPM
t-cells: 8.1 nCPM
nk-cells: 7.4 nCPM
kupffer cells: 7.2 nCPM
lymphatic endothelial cells: 4.8 nCPM

Immune cell

naive CD4 T-cell: 523 nTPM
total PBMC: 509 nTPM
memory CD4 T-cell: 437 nTPM
MAIT T-cell: 338 nTPM
memory CD8 T-cell: 334 nTPM
naive CD8 T-cell: 281 nTPM

Brain region

medulla oblongata: 13 nTPM
cerebral cortex: 12 nTPM
pons: 12 nTPM
thalamus: 12 nTPM
spinal cord: 10 nTPM
basal ganglia: 10 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about GIMAP5.

Disease | AllUniProt

Conditions GIMAP5 is implicated in, by any mechanism.

Portal hypertension, non-cirrhotic, 2 (NCPH2) MIM:619463

Disease | GeneticClinVar

3 pathogenic / likely-pathogenic of 8 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Portal hypertension
Portal hypertension, noncirrhotic, 2

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.88
gnomAD pLI: 0.1
gnomAD missense Z: -0.55
DepMap mean gene effect: 0.14
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of GIMAP5 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads GIMAP5 as an antibody target. Whether an autoantibody or antibody against GIMAP5 could matter depends on whether native GIMAP5 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

GIMAP5 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label GIMAP5 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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