Seroatlas · Human Serome Atlas

KIF21A

Kinesin-like protein KIF21A

Also known as: FEOM1, FLJ20052, KI21A_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q7Z4S6
Gene
KIF21A
Ensembl
ENSG00000139116
Chromosome
12
Canonical length
1674 aa
Protein class
Disease related genes, Human disease related genes, Predicted intracellular proteins
Subcellular location
Cytosol

OverviewNCBI Gene

This gene encodes a member of the KIF4 subfamily of kinesin-like motor proteins. The encoded protein is characterized by an N-terminal motor domain a coiled-coil stalk domain and a C-terminal WD-40 repeat domain. This protein may be involved in microtubule dependent transport. Mutations in this gene are the cause of congenital fibrosis of extraocular muscles-1. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Mar 2010]

Canonical amino-acid sequenceUniProt

1674 residues, UniProt reviewed canonical sequence.

>Q7Z4S6|KIF21A
     1  MLGAPDESSV RVAVRIRPQL AKEKIEGCHI CTSVTPGEPQ VFLGKDKAFT FDYVFDIDSQ
    61  QEQIYIQCIE KLIEGCFEGY NATVFAYGQT GAGKTYTMGT GFDVNIVEEE LGIISRAVKH
   121  LFKSIEEKKH IAIKNGLPAP DFKVNAQFLE LYNEEVLDLF DTTRDIDAKS KKSNIRIHED
   181  STGGIYTVGV TTRTVNTESE MMQCLKLGAL SRTTASTQMN VQSSRSHAIF TIHVCQTRVC
   241  PQIDADNATD NKIISESAQM NEFETLTAKF HFVDLAGSER LKRTGATGER AKEGISINCG
   301  LLALGNVISA LGDKSKRATH VPYRDSKLTR LLQDSLGGNS QTIMIACVSP SDRDFMETLN
   361  TLKYANRARN IKNKVMVNQD RASQQINALR SEITRLQMEL MEYKTGKRII DEEGVESIND
   421  MFHENAMLQT ENNNLRVRIK AMQETVDALR SRITQLVSDQ ANHVLARAGE GNEEISNMIH
   481  SYIKEIEDLR AKLLESEAVN ENLRKNLTRA TARAPYFSGS STFSPTILSS DKETIEIIDL
   541  AKKDLEKLKR KEKRKKKRLQ KLEESNREER SVAGKEDNTD TDQEKKEEKG VSERENNELE
   601  VEESQEVSDH EDEEEEEEEE EDDIDGGESS DESDSESDEK ANYQADLANI TCEIAIKQKL
   661  IDELENSQKR LQTLKKQYEE KLMMLQHKIR DTQLERDQVL QNLGSVESYS EEKAKKVRSE
   721  YEKKLQAMNK ELQRLQAAQK EHARLLKNQS QYEKQLKKLQ QDVMEMKKTK VRLMKQMKEE
   781  QEKARLTESR RNREIAQLKK DQRKRDHQLR LLEAQKRNQE VVLRRKTEEV TALRRQVRPM
   841  SDKVAGKVTR KLSSSDAPAQ DTGSSAAAVE TDASRTGAQQ KMRIPVARVQ ALPTPATNGN
   901  RKKYQRKGLT GRVFISKTAR MKWQLLERRV TDIIMQKMTI SNMEADMNRL LKQREELTKR
   961  REKLSKRREK IVKENGEGDK NVANINEEME SLTANIDYIN DSISDCQANI MQMEEAKEEG
  1021  ETLDVTAVIN ACTLTEARYL LDHFLSMGIN KGLQAAQKEA QIKVLEGRLK QTEITSATQN
  1081  QLLFHMLKEK AELNPELDAL LGHALQDLDS VPLENVEDST DEDAPLNSPG SEGSTLSSDL
  1141  MKLCGEVKPK NKARRRTTTQ MELLYADSSE LASDTSTGDA SLPGPLTPVA EGQEIGMNTE
  1201  TSGTSAREKE LSPPPGLPSK IGSISRQSSL SEKKIPEPSP VTRRKAYEKA EKSKAKEQKH
  1261  SDSGTSEASL SPPSSPPSRP RNELNVFNRL TVSQGNTSVQ QDKSDESDSS LSEVHRSSRR
  1321  GIINPFPASK GIRAFPLQCI HIAEGHTKAV LCVDSTDDLL FTGSKDRTCK VWNLVTGQEI
  1381  MSLGGHPNNV VSVKYCNYTS LVFTVSTSYI KVWDIRDSAK CIRTLTSSGQ VTLGDACSAS
  1441  TSRTVAIPSG ENQINQIALN PTGTFLYAAS GNAVRMWDLK RFQSTGKLTG HLGPVMCLTV
  1501  DQISSGQDLI ITGSKDHYIK MFDVTEGALG TVSPTHNFEP PHYDGIEALT IQGDNLFSGS
  1561  RDNGIKKWDL TQKDLLQQVP NAHKDWVCAL GVVPDHPVLL SGCRGGILKV WNMDTFMPVG
  1621  EMKGHDSPIN AICVNSTHIF TAADDRTVRI WKARNLQDGQ ISDTGDLGED IASN

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against KIF21A can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.42
Highest tissue expression
72 nTPM

Expression across tissuesHPA

Tissue

  • retina: 72 nTPM
  • hypothalamus: 42 nTPM
  • cerebral cortex: 40 nTPM
  • midbrain: 37 nTPM
  • fallopian tube: 32 nTPM
  • cerebellum: 31 nTPM

Single-cell type

  • respiratory ciliated cells: 586 nCPM
  • cardiomyocytes: 497 nCPM
  • esophageal apical cells: 492 nCPM
  • retinal bipolar cells: 445 nCPM
  • fallopian tube ciliated cells: 439 nCPM
  • bergmann glia: 384 nCPM

Immune cell

  • memory CD8 T-cell: 7.3 nTPM
  • gdT-cell: 7.1 nTPM
  • naive CD8 T-cell: 4.8 nTPM
  • memory CD4 T-cell: 4.4 nTPM
  • MAIT T-cell: 3.4 nTPM
  • NK-cell: 3 nTPM

Brain region

  • pons: 168 nTPM
  • medulla oblongata: 160 nTPM
  • hypothalamus: 136 nTPM
  • cerebral cortex: 122 nTPM
  • midbrain: 117 nTPM
  • thalamus: 115 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about KIF21A.

Disease | AllUniProt

Conditions KIF21A is implicated in, by any mechanism.

  • Fibrosis of extraocular muscles, congenital, 1 (CFEOM1) MIM:135700

Disease | GeneticClinVar

15 pathogenic / likely-pathogenic of 414 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

  • Congenital fibrosis of extraocular muscles type 1
  • Fibrosis of extraocular muscles, congenital, 3b
  • KIF21A-related disorder
  • Abnormality of eye movement
  • Inborn genetic diseases

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.46
gnomAD pLI
0
gnomAD missense Z
2.65
DepMap mean gene effect
-0.06
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads KIF21A as an antibody target. Whether an autoantibody or antibody against KIF21A could matter depends on whether native KIF21A is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

KIF21A is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label KIF21A as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/KIF21A. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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