Seroatlas · Human Serome Atlas

RAB15

Ras-related protein Rab-15

Also known as: RAB15_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P59190
Gene: RAB15
Ensembl: ENSG00000139998
Chromosome: 14
Canonical length: 212 aa
Protein class: Predicted intracellular proteins
Subcellular location: Vesicles,Centriolar satellite

OverviewNCBI Gene

Enables G protein activity. Involved in positive regulation of regulated secretory pathway and receptor-mediated endocytosis. Located in cilium; endosome membrane; and perinuclear region of cytoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

212 residues, UniProt reviewed canonical sequence.

>P59190|RAB15
     1  MAKQYDVLFR LLLIGDSGVG KTCLLCRFTD NEFHSSHIST IGVDFKMKTI EVDGIKVRIQ
    61  IWDTAGQERY QTITKQYYRR AQGIFLVYDI SSERSYQHIM KWVSDVDEYA PEGVQKILIG
   121  NKADEEQKRQ VGREQGQQLA KEYGMDFYET SACTNLNIKE SFTRLTELVL QAHRKELEGL
   181  RMRASNELAL AELEEEEGKP EGPANSSKTC WC

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RAB15 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.32
Highest tissue expression: 78 nTPM

Expression across tissuesHPA

Tissue

cerebellum: 78 nTPM
cerebral cortex: 67 nTPM
hippocampal formation: 47 nTPM
parathyroid gland: 37 nTPM
amygdala: 36 nTPM
salivary gland: 34 nTPM

Single-cell type

salivary duct cells: 140 nCPM
conjunctival goblet cells: 57 nCPM
brain excitatory neurons: 49 nCPM
urothelial cells: 47 nCPM
prostatic club cells: 46 nCPM
prostatic hillock cells: 45 nCPM

Immune cell

plasmacytoid DC: 1.7 nTPM
NK-cell: 0.3 nTPM
MAIT T-cell: 0.2 nTPM
gdT-cell: 0.1 nTPM
T-reg: 0.1 nTPM
basophil: 0 nTPM

Brain region

cerebral cortex: 69 nTPM
hippocampal formation: 61 nTPM
white matter: 45 nTPM
basal ganglia: 44 nTPM
amygdala: 41 nTPM
pons: 40 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.82
gnomAD pLI: 0.01
gnomAD missense Z: 1.16
DepMap mean gene effect: -0.05
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of RAB15 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RAB15 as an antibody target. Whether an autoantibody or antibody against RAB15 could matter depends on whether native RAB15 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RAB15 is annotated at the cell surface, where native RAB15 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label RAB15 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...