Seroatlas · Human Serome Atlas

UST

Uronyl 2-sulfotransferase

Also known as: 2OST, UST_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9Y2C2
Gene
UST
Ensembl
ENSG00000111962
Chromosome
6
Canonical length
406 aa
Protein class
Metabolic proteins, Predicted membrane proteins

OverviewNCBI Gene

Uronyl 2-sulfotransferase transfers sulfate to the 2-position of uronyl residues, such as iduronyl residues in dermatan sulfate and glucuronyl residues in chondroitin sulfate (Kobayashi et al., 1999 [PubMed 10187838]).[supplied by OMIM, Mar 2008]

Canonical amino-acid sequenceUniProt

406 residues, UniProt reviewed canonical sequence.

>Q9Y2C2|UST
     1  MKKKQQHPGG GADPWPHGAP MGGAPPGLGS WKRRVPLLPF LRFSLRDYGF CMATLLVFCL
    61  GSLLYQLSGG PPRFLLDLRQ YLGNSTYLDD HGPPPSKVLP FPSQVVYNRV GKCGSRTVVL
   121  LLRILSEKHG FNLVTSDIHN KTRLTKNEQM ELIKNISTAE QPYLFTRHVH FLNFSRFGGD
   181  QPVYINIIRD PVNRFLSNYF FRRFGDWRGE QNHMIRTPSM RQEERYLDIN ECILENYPEC
   241  SNPRLFYIIP YFCGQHPRCR EPGEWALERA KLNVNENFLL VGILEELEDV LLLLERFLPH
   301  YFKGVLSIYK DPEHRKLGNM TVTVKKTVPS PEAVQILYQR MRYEYEFYHY VKEQFHLLKR
   361  KFGLKSHVSK PPLRPHFFIP TPLETEEPID DEEQDDEKWL EDIYKR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against UST can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Other membrane
Secreted
No
Transmembrane segments
1
Mean surface accessibility (rSASA)
0.36
Highest tissue expression
26 nTPM

Expression across tissuesHPA

Tissue

  • thyroid gland: 26 nTPM
  • midbrain: 13 nTPM
  • ovary: 12 nTPM
  • pancreas: 12 nTPM
  • adrenal gland: 12 nTPM
  • hypothalamus: 11 nTPM

Single-cell type

  • fibro-adipogenic progenitors: 623 nCPM
  • oligodendrocyte progenitor cells: 590 nCPM
  • bergmann glia: 526 nCPM
  • renal collecting duct intercalated cells: 462 nCPM
  • adrenal cortex cells: 394 nCPM
  • sertoli cells: 384 nCPM

Immune cell

  • NK-cell: 2.5 nTPM
  • gdT-cell: 0.6 nTPM
  • memory CD8 T-cell: 0.5 nTPM
  • naive B-cell: 0.5 nTPM
  • MAIT T-cell: 0.4 nTPM
  • memory CD4 T-cell: 0.4 nTPM

Brain region

  • medulla oblongata: 58 nTPM
  • thalamus: 46 nTPM
  • midbrain: 36 nTPM
  • hypothalamus: 33 nTPM
  • white matter: 31 nTPM
  • pons: 28 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.49
gnomAD pLI
0.44
gnomAD missense Z
1.14
DepMap mean gene effect
0.13
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of UST in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads UST as an antibody target. Whether an autoantibody or antibody against UST could matter depends on whether native UST is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

UST is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label UST as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/UST. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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