DHX37

Protein identityUniProt · HPA

UniProt accession

Q8IY37

Gene

DHX37

Ensembl

ENSG00000150990

Chromosome

12

Canonical length

1157 aa

Protein class

Disease related genes, Enzymes, Human disease related genes, Potential drug targets, Predicted intracellular proteins

Subcellular location

Nuclear membrane

OverviewNCBI Gene

This gene encodes a DEAD box protein. DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

1157 residues, UniProt reviewed canonical sequence.

>Q8IY37|DHX37
     1  MGKLRRRYNI KGRQQAGPGP SKGPPEPPPV QLELEDKDTL KGVDASNALV LPGKKKKKTK
    61  APPLSKKEKK PLTKKEKKVL QKILEQKEKK SQRAEMLQKL SEVQASEAEM RLFYTTSKLG
   121  TGNRMYHTKE KADEVVAPGQ EKISSLSGAH RKRRRWPSAE EEEEEEEESE SELEEESELD
   181  EDPAAEPAEA GVGTTVAPLP PAPAPSSQPV PAGMTVPPPP AAAPPLPRAL AKPAVFIPVN
   241  RSPEMQEERL KLPILSEEQV IMEAVAEHPI VIVCGETGSG KTTQVPQFLY EAGFSSEDSI
   301  IGVTEPRRVA AVAMSQRVAK EMNLSQRVVS YQIRYEGNVT EETRIKFMTD GVLLKEIQKD
   361  FLLLRYKVVI IDEAHERSVY TDILIGLLSR IVTLRAKRNL PLKLLIMSAT LRVEDFTQNP
   421  RLFAKPPPVI KVESRQFPVT VHFNKRTPLE DYSGECFRKV CKIHRMLPAG GILVFLTGQA
   481  EVHALCRRLR KAFPPSRARP QEKDDDQKDS VEEMRKFKKS RARAKKARAE VLPQINLDHY
   541  SVLPAGEGDE DREAEVDEEE GALDSDLDLD LGDGGQDGGE QPDASLPLHV LPLYSLLAPE
   601  KQAQVFKPPP EGTRLCVVAT NVAETSLTIP GIKYVVDCGK VKKRYYDRVT GVSSFRVTWV
   661  SQASADQRAG RAGRTEPGHC YRLYSSAVFG DFEQFPPPEI TRRPVEDLIL QMKALNVEKV
   721  INFPFPTPPS VEALLAAEEL LIALGALQPP QKAERVKQLQ ENRLSCPITA LGRTMATFPV
   781  APRYAKMLAL SRQHGCLPYA ITIVASMTVR ELFEELDRPA ASDEELTRLK SKRARVAQMK
   841  RTWAGQGASL KLGDLMVLLG AVGACEYASC TPQFCEANGL RYKAMMEIRR LRGQLTTAVN
   901  AVCPEAELFV DPKMQPPTES QVTYLRQIVT AGLGDHLARR VQSEEMLEDK WRNAYKTPLL
   961  DDPVFIHPSS VLFKELPEFV VYQEIVETTK MYMKGVSSVE VQWIPALLPS YCQFDKPLEE
  1021  PAPTYCPERG RVLCHRASVF YRVGWPLPAI EVDFPEGIDR YKHFARFLLE GQVFRKLASY
  1081  RSCLLSSPGT MLKTWARLQP RTESLLRALV AEKADCHEAL LAAWKKNPKY LLAEYCEWLP
  1141  QAMHPDIEKA WPPTTVH

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against DHX37 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.36

Highest tissue expression

17 nTPM

Expression across tissuesHPA

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about DHX37.

Disease | AllUniProt

Conditions DHX37 is implicated in, by any mechanism.

• Neurodevelopmental disorder with brain anomalies and with or without vertebral or cardiac anomalies (NEDBAVC) MIM:618731
• 46,XY sex reversal 11 (SRXY11) MIM:273250

Disease | GeneticClinVar

16 pathogenic / likely-pathogenic of 647 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

• 46,XY sex reversal 11
• Neurodevelopmental disorder with brain anomalies and with or without vertebral or cardiac anomalies
• Neurodevelopmental disorders
• Male infertility with azoospermia or oligozoospermia due to single gene mutation
• Intellectual disability

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.29

gnomAD pLI

0.99

gnomAD missense Z

1.83

DepMap mean gene effect

-1.47

DepMap dependency class

pan

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• brain development
• maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
• positive regulation of male gonad development
• ribosomal small subunit biogenesis
• ribosome assembly
• ribosome biogenesis

Molecular functions

• ATP binding
• ATP hydrolysis activity
• helicase activity
• RNA binding
• RNA helicase activity
• U3 snoRNA binding

Cellular components

• cytoplasm
• nuclear membrane
• nucleolus
• nucleoplasm
• small-subunit processome

Protein domainsUniProt · Pfam · InterPro

• Helicase, C-terminal domain-like
• Helicase-associated domain
• DEAD/DEAH-box helicase domain
• DEAD-box helicase, OB fold
• Helicase superfamily 1/2, ATP-binding domain
• P-loop containing nucleoside triphosphate hydrolase
• Helicase associated domain (HA2), winged-helix domain
• DEAD/DEAH box helicase
• Helicase conserved C-terminal domain
• Helicase associated domain (HA2), winged-helix
• Oligonucleotide/oligosaccharide-binding (OB)-fold
• Helicase associated domain (HA2), ratchet-like
• ATP-dependent RNA helicase DHX37-like, C-terminal domain
• DEAH helicase DHX37 C-terminal domain

KeywordsUniProt

• ATP-binding
• Cytoplasm
• Helicase
• Hydrolase
• Intellectual disability
• Membrane
• Nucleotide-binding
• Nucleus

InteractionsUniProt · HPA

Protein binding partners of DHX37 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• UTP14A