Seroatlas · Human Serome Atlas

SEPTIN10

Septin-10

Also known as: FLJ11619, SEP10_HUMAN, SEPT10

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9P0V9
Gene
SEPTIN10
Ensembl
ENSG00000186522
Chromosome
2
Canonical length
454 aa
Protein class
Predicted intracellular proteins
Subcellular location
Actin filaments,Microtubules,Annulus

OverviewNCBI Gene

This gene encodes a member of the septin family of cytoskeletal proteins with GTPase activity. This protein localizes to the cytoplasm and nucleus and displays GTP-binding and GTPase activity. A pseudogene for this gene is located on chromosome 8. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2012]

Canonical amino-acid sequenceUniProt

454 residues, UniProt reviewed canonical sequence.

>Q9P0V9|SEPTIN10
     1  MASSEVARHL LFQSHMATKT TCMSSQGSDD EQIKRENIRS LTMSGHVGFE SLPDQLVNRS
    61  IQQGFCFNIL CVGETGIGKS TLIDTLFNTN FEDYESSHFC PNVKLKAQTY ELQESNVQLK
   121  LTIVNTVGFG DQINKEESYQ PIVDYIDAQF EAYLQEELKI KRSLFTYHDS RIHVCLYFIS
   181  PTGHSLKTLD LLTMKNLDSK VNIIPVIAKA DTVSKTELQK FKIKLMSELV SNGVQIYQFP
   241  TDDDTIAKVN AAMNGQLPFA VVGSMDEVKV GNKMVKARQY PWGVVQVENE NHCDFVKLRE
   301  MLICTNMEDL REQTHTRHYE LYRRCKLEEM GFTDVGPENK PVSVQETYEA KRHEFHGERQ
   361  RKEEEMKQMF VQRVKEKEAI LKEAERELQA KFEHLKRLHQ EERMKLEEKR RLLEEEIIAF
   421  SKKKATSEIF HSQSFLATGS NLRKDKDRKN SNFL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SEPTIN10 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.39
Highest tissue expression
83 nTPM

Expression across tissuesHPA

Tissue

  • esophagus: 83 nTPM
  • testis: 72 nTPM
  • skin: 69 nTPM
  • spinal cord: 64 nTPM
  • liver: 62 nTPM
  • blood vessel: 62 nTPM

Single-cell type

  • late spermatids: 668 nCPM
  • esophageal apical cells: 480 nCPM
  • early spermatids: 343 nCPM
  • urothelial cells: 289 nCPM
  • choroid plexus epithelial cells: 269 nCPM
  • late primary spermatocytes: 258 nCPM

Immune cell

  • T-reg: 3.6 nTPM
  • classical monocyte: 2.4 nTPM
  • intermediate monocyte: 1.6 nTPM
  • memory CD4 T-cell: 1.5 nTPM
  • non-classical monocyte: 1 nTPM
  • memory B-cell: 0.8 nTPM

Brain region

  • choroid plexus: 122 nTPM
  • medulla oblongata: 98 nTPM
  • white matter: 89 nTPM
  • spinal cord: 66 nTPM
  • pons: 66 nTPM
  • cerebellum: 61 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.17
gnomAD pLI
0
DepMap mean gene effect
-0.18
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SEPTIN10 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SEPTIN10 as an antibody target. Whether an autoantibody or antibody against SEPTIN10 could matter depends on whether native SEPTIN10 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SEPTIN10 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SEPTIN10 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/SEPTIN10. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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