Seroatlas · Human Serome Atlas

RAB20

Ras-related protein Rab-20

Also known as: FLJ20429, RAB20_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9NX57
Gene: RAB20
Ensembl: ENSG00000139832
Chromosome: 13
Canonical length: 234 aa
Protein class: Plasma proteins, Predicted intracellular proteins
Subcellular location: Golgi apparatus,Vesicles

OverviewNCBI Gene

Predicted to enable GTPase activity. Involved in phagosome acidification and phagosome-lysosome fusion. Located in Golgi apparatus and phagocytic vesicle. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

234 residues, UniProt reviewed canonical sequence.

>Q9NX57|RAB20
     1  MRKPDSKIVL LGDMNVGKTS LLQRYMERRF PDTVSTVGGA FYLKQWRSYN ISIWDTAGRE
    61  QFHGLGSMYC RGAAAIILTY DVNHRQSLVE LEDRFLGLTD TASKDCLFAI VGNKVDLTEE
   121  GALAGQEKEE CSPNMDAGDR VSPRAPKQVQ LEDAVALYKK ILKYKMLDEQ DVPAAEQMCF
   181  ETSAKTGYNV DLLFETLFDL VVPMILQQRA ERPSHTVDIS SHKPPKRTRS GCCA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RAB20 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.33
Highest tissue expression: 55 nTPM

Expression across tissuesHPA

Tissue

adrenal gland: 55 nTPM
liver: 49 nTPM
spleen: 43 nTPM
blood vessel: 37 nTPM
adipose tissue: 30 nTPM
lung: 30 nTPM

Single-cell type

neutrophils: 421 nCPM
kupffer cells: 411 nCPM
monocytes: 331 nCPM
hofbauer cells: 270 nCPM
macrophages: 251 nCPM
extravillous trophoblasts: 144 nCPM

Immune cell

classical monocyte: 36 nTPM
intermediate monocyte: 33 nTPM
non-classical monocyte: 27 nTPM
neutrophil: 26 nTPM
myeloid DC: 16 nTPM
total PBMC: 11 nTPM

Brain region

choroid plexus: 12 nTPM
white matter: 9.4 nTPM
thalamus: 7.5 nTPM
hypothalamus: 6.8 nTPM
medulla oblongata: 6.6 nTPM
pons: 6.3 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.6
gnomAD pLI: 0
gnomAD missense Z: 0.7
DepMap mean gene effect: 0.12
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RAB20 as an antibody target. Whether an autoantibody or antibody against RAB20 could matter depends on whether native RAB20 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RAB20 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label RAB20 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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