Seroatlas · Human Serome Atlas

RHOC

Rho-related GTP-binding protein RhoC

Also known as: ARH9, ARHC, RHOC_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P08134
Gene
RHOC
Ensembl
ENSG00000155366
Chromosome
1
Canonical length
193 aa
Protein class
Cancer-related genes, Predicted intracellular proteins

OverviewNCBI Gene

This gene encodes a member of the Rho family of small GTPases, which cycle between inactive GDP-bound and active GTP-bound states and function as molecular switches in signal transduction cascades. Rho proteins promote reorganization of the actin cytoskeleton and regulate cell shape, attachment, and motility. The protein encoded by this gene is prenylated at its C-terminus, and localizes to the cytoplasm and plasma membrane. It is thought to be important in cell locomotion. Overexpression of this gene is associated with tumor cell proliferation and metastasis. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

193 residues, UniProt reviewed canonical sequence.

>P08134|RHOC
     1  MAAIRKKLVI VGDGACGKTC LLIVFSKDQF PEVYVPTVFE NYIADIEVDG KQVELALWDT
    61  AGQEDYDRLR PLSYPDTDVI LMCFSIDSPD SLENIPEKWT PEVKHFCPNV PIILVGNKKD
   121  LRQDEHTRRE LAKMKQEPVR SEEGRDMANR ISAFGYLECS AKTKEGVREV FEMATRAGLQ
   181  VRKNKRRRGC PIL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RHOC can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.29
Highest tissue expression
604 nTPM

Expression across tissuesHPA

Tissue

  • parathyroid gland: 604 nTPM
  • blood vessel: 461 nTPM
  • heart muscle: 378 nTPM
  • kidney: 349 nTPM
  • lung: 303 nTPM
  • epididymis: 295 nTPM

Single-cell type

  • enterocytes: 854 nCPM
  • colonocytes: 854 nCPM
  • epididymal principal cells: 692 nCPM
  • extravillous trophoblasts: 655 nCPM
  • decidual stromal cells: 550 nCPM
  • epididymal basal cells: 432 nCPM

Immune cell

  • non-classical monocyte: 1,403 nTPM
  • intermediate monocyte: 806 nTPM
  • NK-cell: 348 nTPM
  • total PBMC: 316 nTPM
  • myeloid DC: 245 nTPM
  • gdT-cell: 217 nTPM

Brain region

  • hypothalamus: 163 nTPM
  • medulla oblongata: 161 nTPM
  • thalamus: 153 nTPM
  • pons: 131 nTPM
  • spinal cord: 127 nTPM
  • midbrain: 126 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about RHOC.

Disease | ImmuneIEDB

Conditions an epitope on RHOC was assayed in.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.52
gnomAD pLI
0.77
gnomAD missense Z
1.85
DepMap mean gene effect
-0.27
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of RHOC in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RHOC as an antibody target. Whether an autoantibody or antibody against RHOC could matter depends on whether native RHOC is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RHOC is annotated at the cell surface, where native RHOC is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label RHOC as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/RHOC. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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