Seroatlas · Human Serome Atlas

DDX24

ATP-dependent RNA helicase DDX24

Also known as: DDX24_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9GZR7
Gene: DDX24
Ensembl: ENSG00000089737
Chromosome: 14
Canonical length: 859 aa
Protein class: Enzymes, Plasma proteins, Predicted intracellular proteins
Subcellular location: Nucleoli,Cytosol

OverviewNCBI Gene

DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein, which shows little similarity to any of the other known human DEAD box proteins, but shows a high similarity to mouse Ddx24 at the amino acid level. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

859 residues, UniProt reviewed canonical sequence.

>Q9GZR7|DDX24
     1  MKLKDTKSRP KQSSCGKFQT KGIKVVGKWK EVKIDPNMFA DGQMDDLVCF EELTDYQLVS
    61  PAKNPSSLFS KEAPKRKAQA VSEEEEEEEG KSSSPKKKIK LKKSKNVATE GTSTQKEFEV
   121  KDPELEAQGD DMVCDDPEAG EMTSENLVQT APKKKKNKGK KGLEPSQSTA AKVPKKAKTW
   181  IPEVHDQKAD VSAWKDLFVP RPVLRALSFL GFSAPTPIQA LTLAPAIRDK LDILGAAETG
   241  SGKTLAFAIP MIHAVLQWQK RNAAPPPSNT EAPPGETRTE AGAETRSPGK AEAESDALPD
   301  DTVIESEALP SDIAAEARAK TGGTVSDQAL LFGDDDAGEG PSSLIREKPV PKQNENEEEN
   361  LDKEQTGNLK QELDDKSATC KAYPKRPLLG LVLTPTRELA VQVKQHIDAV ARFTGIKTAI
   421  LVGGMSTQKQ QRMLNRRPEI VVATPGRLWE LIKEKHYHLR NLRQLRCLVV DEADRMVEKG
   481  HFAELSQLLE MLNDSQYNPK RQTLVFSATL TLVHQAPARI LHKKHTKKMD KTAKLDLLMQ
   541  KIGMRGKPKV IDLTRNEATV ETLTETKIHC ETDEKDFYLY YFLMQYPGRS LVFANSISCI
   601  KRLSGLLKVL DIMPLTLHAC MHQKQRLRNL EQFARLEDCV LLATDVAARG LDIPKVQHVI
   661  HYQVPRTSEI YVHRSGRTAR ATNEGLSLML IGPEDVINFK KIYKTLKKDE DIPLFPVQTK
   721  YMDVVKERIR LARQIEKSEY RNFQACLHNS WIEQAAAALE IELEEDMYKG GKADQQEERR
   781  RQKQMKVLKK ELRHLLSQPL FTESQKTKYP TQSGKPPLLV SAPSKSESAL SCLSKQKKKK
   841  TKKPKEPQPE QPQPSTSAN

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against DDX24 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.44
Highest tissue expression: 115 nTPM

Expression across tissuesHPA

Tissue

blood vessel: 115 nTPM
cerebral cortex: 104 nTPM
adrenal gland: 99 nTPM
skeletal muscle: 97 nTPM
cerebellum: 94 nTPM
basal ganglia: 93 nTPM

Single-cell type

other brain neurons: 272 nCPM
brain inhibitory neurons: 169 nCPM
brain excitatory neurons: 160 nCPM
early primary spermatocytes: 101 nCPM
endometrial secretory cells: 90 nCPM
oligodendrocytes: 86 nCPM

Immune cell

basophil: 7.6 nTPM
naive CD8 T-cell: 2.2 nTPM
NK-cell: 2 nTPM
plasmacytoid DC: 1.8 nTPM
T-reg: 1.8 nTPM
memory CD8 T-cell: 1.7 nTPM

Brain region

cerebral cortex: 13 nTPM
cerebellum: 11 nTPM
medulla oblongata: 10 nTPM
pons: 9.9 nTPM
hypothalamus: 9.8 nTPM
midbrain: 9.8 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about DDX24.

Disease | ImmuneIEDB

Conditions an epitope on DDX24 was assayed in.

skin melanoma T cell

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.38
gnomAD pLI: 0.68
gnomAD missense Z: 0.09
DepMap mean gene effect: -0.92
DepMap dependency class: common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

RNA metabolic process

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of DDX24 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads DDX24 as an antibody target. Whether an autoantibody or antibody against DDX24 could matter depends on whether native DDX24 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

DDX24 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label DDX24 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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