Seroatlas · Human Serome Atlas

SULT1C4

Sulfotransferase 1C4

Also known as: ST1C4_HUMAN, SULT1C, SULT1C2

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: O75897
Gene: SULT1C4
Ensembl: ENSG00000198075
Chromosome: 2
Canonical length: 302 aa
Protein class: Enzymes, Metabolic proteins, Predicted intracellular proteins
Subcellular location: Cytosol

OverviewNCBI Gene

Sulfotransferase enzymes catalyze the sulfate conjugation of many hormones, neurotransmitters, drugs, and xenobiotic compounds. These cytosolic enzymes are different in their tissue distributions and substrate specificities. The gene structure (number and length of exons) is similar among family members. This gene encodes a protein that belongs to the SULT1 subfamily, responsible for transferring a sulfo moiety from PAPS to phenol-containing compounds. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

302 residues, UniProt reviewed canonical sequence.

>O75897|SULT1C4
     1  MALHDMEDFT FDGTKRLSVN YVKGILQPTD TCDIWDKIWN FQAKPDDLLI STYPKAGTTW
    61  TQEIVELIQN EGDVEKSKRA PTHQRFPFLE MKIPSLGSGL EQAHAMPSPR ILKTHLPFHL
   121  LPPSLLEKNC KIIYVARNPK DNMVSYYHFQ RMNKALPAPG TWEEYFETFL AGKVCWGSWH
   181  EHVKGWWEAK DKHRILYLFY EDMKKNPKHE IQKLAEFIGK KLDDKVLDKI VHYTSFDVMK
   241  QNPMANYSSI PAEIMDHSIS PFMRKGAVGD WKKHFTVAQN ERFDEDYKKK MTDTRLTFHF
   301  QF

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SULT1C4 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.24
Highest tissue expression: 29 nTPM

Expression across tissuesHPA

Tissue

ovary: 29 nTPM
gallbladder: 26 nTPM
midbrain: 21 nTPM
cervix: 21 nTPM
basal ganglia: 19 nTPM
hypothalamus: 18 nTPM

Single-cell type

epididymal efferent duct ciliated cells: 81 nCPM
cholangiocytes: 69 nCPM
proximal tubule cells: 63 nCPM
ependymal cells: 56 nCPM
ovarian stromal cells: 48 nCPM
hematopoietic stem cells: 41 nCPM

Immune cell

basophil: 0.3 nTPM
neutrophil: 0.1 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM

Brain region

midbrain: 42 nTPM
medulla oblongata: 27 nTPM
hypothalamus: 24 nTPM
thalamus: 24 nTPM
spinal cord: 22 nTPM
pons: 21 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.2
gnomAD pLI: 0
gnomAD missense Z: 0.24
DepMap mean gene effect: -0.06
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SULT1C4 as an antibody target. Whether an autoantibody or antibody against SULT1C4 could matter depends on whether native SULT1C4 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SULT1C4 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SULT1C4 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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