Seroatlas · Human Serome Atlas

DYNC1LI1

Cytoplasmic dynein 1 light intermediate chain 1

Also known as: DC1L1_HUMAN, DNCLI1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9Y6G9
Gene
DYNC1LI1
Ensembl
ENSG00000144635
Chromosome
3
Canonical length
523 aa
Protein class
Predicted intracellular proteins
Subcellular location
Nucleoplasm,Plasma membrane,Centrosome,Cytosol
Quaternary structure
Homodimer

OverviewNCBI Gene

The protein encoded by this gene belongs to light intermediate subunit family, whose members are components of the multiprotein cytoplasmic dynein complex, which is involved in intracellular trafficking and chromosome segregation during mitosis. The protein plays a role in moving the spindle assembly checkpoint (SAC) from kinetochores to spindle poles. The protein may also mediate binding to other cargo molecules to facilitate intracellular vesicle trafficking. [provided by RefSeq, Jul 2016]

Canonical amino-acid sequenceUniProt

523 residues, UniProt reviewed canonical sequence.

>Q9Y6G9|DYNC1LI1
     1  MAAVGRVGSF GSSPPGLSST YTGGPLGNEI ASGNGGAAAG DDEDGQNLWS CILSEVSTRS
    61  RSKLPAGKNV LLLGEDGAGK TSLIRKIQGI EEYKKGRGLE YLYLNVHDED RDDQTRCNVW
   121  ILDGDLYHKG LLKFSLDAVS LKDTLVMLVV DMSKPWTALD SLQKWASVVR EHVDKLKIPP
   181  EEMKQMEQKL IRDFQEYVEP GEDFPASPQR RNTASQEDKD DSVVLPLGAD TLTHNLGIPV
   241  LVVCTKCDAI SVLEKEHDYR DEHFDFIQSH IRKFCLQYGA ALIYTSVKEN KNIDLVYKYI
   301  VQKLYGFPYK IPAVVVEKDA VFIPAGWDND KKIGILHENF QTLKAEDNFE DIITKPPVRK
   361  FVHEKEIMAE DDQVFLMKLQ SLLAKQPPTA AGRPVDASPR VPGGSPRTPN RSVSSNVASV
   421  SPIPAGSKKI DPNMKAGATS EGVLANFFNS LLSKKTGSPG GPGVSGGSPA GGAGGGSSGL
   481  PPSTKKSGQK PVLDVHAELD RITRKPVTVS PTTPTSPTEG EAS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against DYNC1LI1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Other membrane
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.48
Highest tissue expression
45 nTPM

Expression across tissuesHPA

Tissue

  • heart muscle: 45 nTPM
  • skeletal muscle: 44 nTPM
  • testis: 38 nTPM
  • retina: 37 nTPM
  • bone marrow: 35 nTPM
  • skin: 33 nTPM

Single-cell type

  • neutrophils: 248 nCPM
  • late primary spermatocytes: 239 nCPM
  • oocytes: 203 nCPM
  • differentiating spermatogonia: 178 nCPM
  • early primary spermatocytes: 178 nCPM
  • undifferentiated spermatogonia: 156 nCPM

Immune cell

  • neutrophil: 63 nTPM
  • non-classical monocyte: 60 nTPM
  • intermediate monocyte: 36 nTPM
  • basophil: 33 nTPM
  • myeloid DC: 33 nTPM
  • classical monocyte: 30 nTPM

Brain region

  • cerebellum: 49 nTPM
  • pons: 47 nTPM
  • hypothalamus: 43 nTPM
  • medulla oblongata: 40 nTPM
  • cerebral cortex: 39 nTPM
  • thalamus: 37 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.33
gnomAD pLI
0.96
gnomAD missense Z
1.04
DepMap mean gene effect
-0.17
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of DYNC1LI1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads DYNC1LI1 as an antibody target. Whether an autoantibody or antibody against DYNC1LI1 could matter depends on whether native DYNC1LI1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

DYNC1LI1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label DYNC1LI1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/DYNC1LI1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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