Seroatlas · Human Serome Atlas

RAD51C

DNA repair protein RAD51 homolog 3

Also known as: FANCO, RA51C_HUMAN, RAD51L2

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
O43502
Gene
RAD51C
Ensembl
ENSG00000108384
Chromosome
17
Canonical length
376 aa
Protein class
Disease related genes, Human disease related genes, Predicted intracellular proteins
Subcellular location
Nucleoplasm,Vesicles,Cell Junctions,Mitochondria,Cytosol

OverviewNCBI Gene

This gene is a member of the RAD51 family. RAD51 family members are highly similar to bacterial RecA and Saccharomyces cerevisiae Rad51 and are known to be involved in the homologous recombination and repair of DNA. This protein can interact with other RAD51 paralogs and is reported to be important for Holliday junction resolution. Mutations in this gene are associated with Fanconi anemia-like syndrome. This gene is one of four localized to a region of chromosome 17q23 where amplification occurs frequently in breast tumors. Overexpression of the four genes during amplification has been observed and suggests a possible role in tumor progression. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]

Canonical amino-acid sequenceUniProt

376 residues, UniProt reviewed canonical sequence.

>O43502|RAD51C
     1  MRGKTFRFEM QRDLVSFPLS PAVRVKLVSA GFQTAEELLE VKPSELSKEV GISKAEALET
    61  LQIIRRECLT NKPRYAGTSE SHKKCTALEL LEQEHTQGFI ITFCSALDDI LGGGVPLMKT
   121  TEICGAPGVG KTQLCMQLAV DVQIPECFGG VAGEAVFIDT EGSFMVDRVV DLATACIQHL
   181  QLIAEKHKGE EHRKALEDFT LDNILSHIYY FRCRDYTELL AQVYLLPDFL SEHSKVRLVI
   241  VDGIAFPFRH DLDDLSLRTR LLNGLAQQMI SLANNHRLAV ILTNQMTTKI DRNQALLVPA
   301  LGESWGHAAT IRLIFHWDRK QRLATLYKSP SQKECTVLFQ IKPQGFRDTV VTSACSLQTE
   361  GSLSTRKRSR DPEEEL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RAD51C can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.33
Highest tissue expression
19 nTPM

Expression across tissuesHPA

Tissue

  • bone marrow: 19 nTPM
  • adrenal gland: 19 nTPM
  • cerebral cortex: 19 nTPM
  • heart muscle: 18 nTPM
  • epididymis: 18 nTPM
  • amygdala: 17 nTPM

Single-cell type

  • oocytes: 216 nCPM
  • early primary spermatocytes: 165 nCPM
  • late primary spermatocytes: 150 nCPM
  • extravillous trophoblasts: 129 nCPM
  • early spermatids: 95 nCPM
  • migrating cytotrophoblasts: 91 nCPM

Immune cell

  • T-reg: 22 nTPM
  • basophil: 17 nTPM
  • naive CD4 T-cell: 14 nTPM
  • memory B-cell: 14 nTPM
  • naive CD8 T-cell: 13 nTPM
  • memory CD8 T-cell: 13 nTPM

Brain region

  • cerebellum: 33 nTPM
  • white matter: 29 nTPM
  • cerebral cortex: 27 nTPM
  • hippocampal formation: 27 nTPM
  • pons: 26 nTPM
  • amygdala: 26 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about RAD51C.

Disease | AllUniProt

Conditions RAD51C is implicated in, by any mechanism.

  • Fanconi anemia complementation group O (FANCO) MIM:613390
  • Breast-ovarian cancer, familial, 3 (BROVCA3) MIM:613399

Disease | GeneticClinVar

350 pathogenic / likely-pathogenic of 2,341 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.49
gnomAD pLI
0
gnomAD missense Z
0.13
DepMap mean gene effect
-0.87
DepMap dependency class
common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 8% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of RAD51C in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RAD51C as an antibody target. Whether an autoantibody or antibody against RAD51C could matter depends on whether native RAD51C is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RAD51C is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label RAD51C as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/RAD51C. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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