RERGL
Ras-related and estrogen-regulated growth inhibitor-like protein
Also known as: FLJ22655, RERGL_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q9H628
- Gene
- RERGL
- Ensembl
- ENSG00000111404
- Chromosome
- 12
- Canonical length
- 205 aa
- Protein class
- Enzymes, Predicted intracellular proteins
- Subcellular location
- Nucleoplasm
OverviewNCBI Gene
Predicted to enable G protein activity and GTP binding activity. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
205 residues, UniProt reviewed canonical sequence.
>Q9H628|RERGL
1 MSNFLHLKYN EKSVSVTKAL TVRFLTKRFI GEYASNFESI YKKHLCLERK QLNLEIYDPC
61 SQTQKAKFSL TSELHWADGF VIVYDISDRS SFAFAKALIY RIREPQTSHC KRAVESAVFL
121 VGNKRDLCHV REVGWEEGQK LALENRCQFC ELSAAEQSLE VEMMFIRIIK DILINFKLKE
181 KRRPSGSKSM AKLINNVFGK RRKSVLocalizationUniProt · AlphaFold · HPA
Whether an antibody against RERGL can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Unknown
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.32
- Highest tissue expression
- 167 nTPM
Expression across tissuesHPA
Tissue
- blood vessel: 167 nTPM
- adipose tissue: 41 nTPM
- epididymis: 36 nTPM
- endometrium: 31 nTPM
- cervix: 30 nTPM
- tongue: 28 nTPM
Single-cell type
- vascular smooth muscle cells: 850 nCPM
- ependymal cells: 47 nCPM
- proximal tubule cells: 44 nCPM
- pericytes: 39 nCPM
- renal collecting duct intercalated cells: 31 nCPM
- bergmann glia: 29 nCPM
Immune cell
- basophil: 0 nTPM
- classical monocyte: 0 nTPM
- eosinophil: 0 nTPM
- gdT-cell: 0 nTPM
- intermediate monocyte: 0 nTPM
- MAIT T-cell: 0 nTPM
Brain region
- hypothalamus: 6.5 nTPM
- thalamus: 5.6 nTPM
- medulla oblongata: 5.2 nTPM
- pons: 5 nTPM
- cerebral cortex: 4.2 nTPM
- midbrain: 4.2 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.69
- gnomAD pLI
- 0
- gnomAD missense Z
- -0.25
- DepMap mean gene effect
- 0.13
- DepMap dependency class
- none
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Molecular functions
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads RERGL as an antibody target. Whether an autoantibody or antibody against RERGL could matter depends on whether native RERGL is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
RERGL is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label RERGL as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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