Seroatlas · Human Serome Atlas

GNAZ

Guanine nucleotide-binding protein G(z) subunit alpha

Also known as: GNAZ_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P19086
Gene: GNAZ
Ensembl: ENSG00000128266
Chromosome: 22
Canonical length: 355 aa
Protein class: Predicted intracellular proteins
Subcellular location: Vesicles

OverviewNCBI Gene

The protein encoded by this gene is a member of a G protein subfamily that mediates signal transduction in pertussis toxin-insensitive systms. This encoded protein may play a role in maintaining the ionic balance of perilymphatic and endolymphatic cochlear fluids. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

355 residues, UniProt reviewed canonical sequence.

>P19086|GNAZ
     1  MGCRQSSEEK EAARRSRRID RHLRSESQRQ RREIKLLLLG TSNSGKSTIV KQMKIIHSGG
    61  FNLEACKEYK PLIIYNAIDS LTRIIRALAA LRIDFHNPDR AYDAVQLFAL TGPAESKGEI
   121  TPELLGVMRR LWADPGAQAC FSRSSEYHLE DNAAYYLNDL ERIAAADYIP TVEDILRSRD
   181  MTTGIVENKF TFKELTFKMV DVGGQRSERK KWIHCFEGVT AIIFCVELSG YDLKLYEDNQ
   241  TSRMAESLRL FDSICNNNWF INTSLILFLN KKDLLAEKIR RIPLTICFPE YKGQNTYEEA
   301  AVYIQRQFED LNRNKETKEI YSHFTCATDT SNIQFVFDAV TDVIIQNNLK YIGLC

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against GNAZ can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.27
Highest tissue expression: 45 nTPM

Expression across tissuesHPA

Tissue

spinal cord: 45 nTPM
cerebral cortex: 39 nTPM
hippocampal formation: 37 nTPM
cerebellum: 37 nTPM
midbrain: 34 nTPM
amygdala: 32 nTPM

Single-cell type

platelets: 338 nCPM
megakaryocytes: 247 nCPM
retinal horizontal cells: 72 nCPM
corticotrophs: 71 nCPM
retinal pigment epithelial cells: 55 nCPM
late spermatids: 55 nCPM

Immune cell

total PBMC: 2 nTPM
basophil: 1 nTPM
non-classical monocyte: 0.6 nTPM
naive B-cell: 0.4 nTPM
neutrophil: 0.3 nTPM
eosinophil: 0.2 nTPM

Brain region

cerebral cortex: 82 nTPM
white matter: 80 nTPM
pons: 76 nTPM
hippocampal formation: 74 nTPM
midbrain: 73 nTPM
amygdala: 72 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.29
gnomAD pLI: 0.96
gnomAD missense Z: 3.35
DepMap mean gene effect: 0.12
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of GNAZ in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads GNAZ as an antibody target. Whether an autoantibody or antibody against GNAZ could matter depends on whether native GNAZ is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

GNAZ is annotated at the cell surface, where native GNAZ is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label GNAZ as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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