Seroatlas · Human Serome Atlas

NLRP3

NACHT, LRR and PYD domains-containing protein 3

Also known as: NLRP3_HUMAN

Cross-references: UniProt · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q96P20
Gene: NLRP3
Canonical length: 1036 aa
Protein class: Cancer-related genes, Human disease related genes, Predicted intracellular proteins
Quaternary structure: Homodecamer

OverviewNCBI Gene

No narrative summary is available for NLRP3 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

1036 residues, UniProt reviewed canonical sequence.

>Q96P20|NLRP3
     1  MKMASTRCKL ARYLEDLEDV DLKKFKMHLE DYPPQKGCIP LPRGQTEKAD HVDLATLMID
    61  FNGEEKAWAM AVWIFAAINR RDLYEKAKRD EPKWGSDNAR VSNPTVICQE DSIEEEWMGL
   121  LEYLSRISIC KMKKDYRKKY RKYVRSRFQC IEDRNARLGE SVSLNKRYTR LRLIKEHRSQ
   181  QEREQELLAI GKTKTCESPV SPIKMELLFD PDDEHSEPVH TVVFQGAAGI GKTILARKMM
   241  LDWASGTLYQ DRFDYLFYIH CREVSLVTQR SLGDLIMSCC PDPNPPIHKI VRKPSRILFL
   301  MDGFDELQGA FDEHIGPLCT DWQKAERGDI LLSSLIRKKL LPEASLLITT RPVALEKLQH
   361  LLDHPRHVEI LGFSEAKRKE YFFKYFSDEA QARAAFSLIQ ENEVLFTMCF IPLVCWIVCT
   421  GLKQQMESGK SLAQTSKTTT AVYVFFLSSL LQPRGGSQEH GLCAHLWGLC SLAADGIWNQ
   481  KILFEESDLR NHGLQKADVS AFLRMNLFQK EVDCEKFYSF IHMTFQEFFA AMYYLLEEEK
   541  EGRTNVPGSR LKLPSRDVTV LLENYGKFEK GYLIFVVRFL FGLVNQERTS YLEKKLSCKI
   601  SQQIRLELLK WIEVKAKAKK LQIQPSQLEL FYCLYEMQEE DFVQRAMDYF PKIEINLSTR
   661  MDHMVSSFCI ENCHRVESLS LGFLHNMPKE EEEEEKEGRH LDMVQCVLPS SSHAACSHGL
   721  VNSHLTSSFC RGLFSVLSTS QSLTELDLSD NSLGDPGMRV LCETLQHPGC NIRRLWLGRC
   781  GLSHECCFDI SLVLSSNQKL VELDLSDNAL GDFGIRLLCV GLKHLLCNLK KLWLVSCCLT
   841  SACCQDLASV LSTSHSLTRL YVGENALGDS GVAILCEKAK NPQCNLQKLG LVNSGLTSVC
   901  CSALSSVLST NQNLTHLYLR GNTLGDKGIK LLCEGLLHPD CKLQVLELDN CNLTSHCCWD
   961  LSTLLTSSQS LRKLSLGNND LGDLGVMMFC EVLKQQSCLL QNLGLSEMYF NYETKSALET
  1021  LQEEKPELTV VFEPSW

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against NLRP3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Secreted
Secreted: Yes
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.27
Highest tissue expression: 52 nTPM

Expression across tissuesHPA

Tissue

bone marrow: 52 nTPM
appendix: 9.4 nTPM
adipose tissue: 7.9 nTPM
gallbladder: 6.1 nTPM
urinary bladder: 5.9 nTPM
smooth muscle: 4.5 nTPM

Single-cell type

monocytes: 260 nCPM
neutrophils: 173 nCPM
microglia: 67 nCPM
macrophages: 48 nCPM
cdc: 29 nCPM
monocyte progenitors: 24 nCPM

Immune cell

basophil: 130 nTPM
myeloid DC: 37 nTPM
classical monocyte: 36 nTPM
intermediate monocyte: 22 nTPM
total PBMC: 12 nTPM
non-classical monocyte: 12 nTPM

Brain region

white matter: 9.3 nTPM
medulla oblongata: 6.4 nTPM
spinal cord: 5.9 nTPM
pons: 5.8 nTPM
hypothalamus: 5.3 nTPM
thalamus: 5.3 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about NLRP3.

Disease | AllUniProt

Conditions NLRP3 is implicated in, by any mechanism.

Familial cold autoinflammatory syndrome 1 (FCAS1) MIM:120100
Muckle-Wells syndrome (MWS) MIM:191900
Chronic infantile neurologic cutaneous and articular syndrome (CINCA) MIM:607115
Keratoendothelitis fugax hereditaria (KEFH) MIM:148200
Deafness, autosomal dominant, 34, with or without inflammation (DFNA34) MIM:617772

Disease | GeneticClinVar

65 pathogenic / likely-pathogenic of 1,248 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Familial cold autoinflammatory syndrome 1
Cryopyrin associated periodic syndrome
Familial amyloid nephropathy with urticaria AND deafness
Chronic infantile neurological, cutaneous and articular syndrome
Autoinflammatory syndrome

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.52
gnomAD pLI: 0
gnomAD missense Z: 2.14
DepMap mean gene effect: 0.09
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of NLRP3 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads NLRP3 as an antibody target. Whether an autoantibody or antibody against NLRP3 could matter depends on whether native NLRP3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

NLRP3 is annotated as secreted, so native NLRP3 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label NLRP3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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