Seroatlas · Human Serome Atlas

RUVBL1

RuvB-like 1

Also known as: ECP54, INO80H, NMP238, Pontin52, RUVB1_HUMAN, RVB1, TIH1, TIP49, TIP49a

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9Y265
Gene
RUVBL1
Ensembl
ENSG00000175792
Chromosome
3
Canonical length
456 aa
Protein class
Enzymes, Plasma proteins, Predicted intracellular proteins
Subcellular location
Nucleoplasm,Nuclear speckles,Basal body,Cytosol

OverviewNCBI Gene

This gene encodes a protein that has both DNA-dependent ATPase and DNA helicase activities and belongs to the ATPases associated with diverse cellular activities (AAA+) protein family. The encoded protein associates with several multisubunit transcriptional complexes and with protein complexes involved in both ATP-dependent remodeling and histone modification. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016]

Canonical amino-acid sequenceUniProt

456 residues, UniProt reviewed canonical sequence.

>Q9Y265|RUVBL1
     1  MKIEEVKSTT KTQRIASHSH VKGLGLDESG LAKQAASGLV GQENAREACG VIVELIKSKK
    61  MAGRAVLLAG PPGTGKTALA LAIAQELGSK VPFCPMVGSE VYSTEIKKTE VLMENFRRAI
   121  GLRIKETKEV YEGEVTELTP CETENPMGGY GKTISHVIIG LKTAKGTKQL KLDPSIFESL
   181  QKERVEAGDV IYIEANSGAV KRQGRCDTYA TEFDLEAEEY VPLPKGDVHK KKEIIQDVTL
   241  HDLDVANARP QGGQDILSMM GQLMKPKKTE ITDKLRGEIN KVVNKYIDQG IAELVPGVLF
   301  VDEVHMLDIE CFTYLHRALE SSIAPIVIFA SNRGNCVIRG TEDITSPHGI PLDLLDRVMI
   361  IRTMLYTPQE MKQIIKIRAQ TEGINISEEA LNHLGEIGTK TTLRYSVQLL TPANLLAKIN
   421  GKDSIEKEHV EEISELFYDA KSSAKILADQ QDKYMK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RUVBL1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.32
Highest tissue expression
26 nTPM

Expression across tissuesHPA

Tissue

  • testis: 26 nTPM
  • esophagus: 23 nTPM
  • fallopian tube: 23 nTPM
  • heart muscle: 23 nTPM
  • kidney: 21 nTPM
  • endometrium: 20 nTPM

Single-cell type

  • epicardial cells: 325 nCPM
  • fallopian tube ciliated cells: 275 nCPM
  • respiratory ciliated cells: 273 nCPM
  • endometrial ciliated cells: 153 nCPM
  • epididymal efferent duct ciliated cells: 153 nCPM
  • early primary spermatocytes: 122 nCPM

Immune cell

  • T-reg: 31 nTPM
  • MAIT T-cell: 20 nTPM
  • memory CD8 T-cell: 20 nTPM
  • memory CD4 T-cell: 19 nTPM
  • naive CD8 T-cell: 18 nTPM
  • NK-cell: 16 nTPM

Brain region

  • choroid plexus: 16 nTPM
  • midbrain: 14 nTPM
  • medulla oblongata: 11 nTPM
  • pons: 9.7 nTPM
  • white matter: 8.8 nTPM
  • thalamus: 8.7 nTPM

ReferencesPubMed · IEDB

Publications for RUVBL1 from three distinct lines of evidence, kept separate because they answer different questions: whether antibodies are directed at the protein, whether a B-cell epitope has been mapped on it, and whether a T-cell epitope has. Each is labelled with its source.

Reference: AutoantibodyPubMed

2 publications

Sources: PubMed — antigen-level antibody evidence from a custom retrieval. Records matching a controlled set of autoantibody terms (the MeSH descriptors Autoantibodies and Autoantigens, with title and abstract term variants) were obtained through NCBI E-utilities, and their titles and abstracts parsed for constructions that direct an antibody at a named protein rather than for co-occurrence. Captured names were resolved against UniProt nomenclature and each antigen adjudicated individually against the source text. Bibliographic records from PubMed and MeSH, U.S. National Library of Medicine; citation metrics from NIH iCite (Hutchins et al., PLoS Biology 2016). Titles link to PubMed; abstracts are not reproduced here. The NLM does not endorse this analysis.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.19
gnomAD pLI
1
gnomAD missense Z
3.39
DepMap mean gene effect
-1.79
DepMap dependency class
pan

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 10% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of RUVBL1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RUVBL1 as an antibody target. Whether an autoantibody or antibody against RUVBL1 could matter depends on whether native RUVBL1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RUVBL1 is annotated at the cell surface, where native RUVBL1 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label RUVBL1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/RUVBL1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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