GNA15

Protein identityUniProt · HPA

UniProt accession

P30679

Gene

GNA15

Ensembl

ENSG00000060558

Chromosome

19

Canonical length

374 aa

Protein class

Plasma proteins, Predicted intracellular proteins

OverviewNCBI Gene

Enables G protein-coupled receptor binding activity. Acts upstream of or within with a positive effect on calcium-mediated signaling. Predicted to be located in plasma membrane. Predicted to be part of heterotrimeric G-protein complex. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

374 residues, UniProt reviewed canonical sequence.

>P30679|GNA15
     1  MARSLTWRCC PWCLTEDEKA AARVDQEINR ILLEQKKQDR GELKLLLLGP GESGKSTFIK
    61  QMRIIHGAGY SEEERKGFRP LVYQNIFVSM RAMIEAMERL QIPFSRPESK HHASLVMSQD
   121  PYKVTTFEKR YAAAMQWLWR DAGIRACYER RREFHLLDSA VYYLSHLERI TEEGYVPTAQ
   181  DVLRSRMPTT GINEYCFSVQ KTNLRIVDVG GQKSERKKWI HCFENVIALI YLASLSEYDQ
   241  CLEENNQENR MKESLALFGT ILELPWFKST SVILFLNKTD ILEEKIPTSH LATYFPSFQG
   301  PKQDAEAAKR FILDMYTRMY TGCVDGPEGS KKGARSRRLF SHYTCATDTQ NIRKVFKDVR
   361  DSVLARYLDE INLL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against GNA15 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Cell surface

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.28

Highest tissue expression

99 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.7

gnomAD pLI

0.01

gnomAD missense Z

1.18

DepMap mean gene effect

0.03

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• calcium-mediated signaling
• phospholipase C-activating G protein-coupled acetylcholine receptor signaling pathway

Molecular functions

• G protein-coupled receptor binding
• G-protein beta/gamma-subunit complex binding
• GTP binding
• GTPase activity
• metal ion binding

Cellular components

• heterotrimeric G-protein complex
• plasma membrane
• synapse

Protein domainsUniProt · Pfam · InterPro

• G-protein alpha subunit, group Q
• Guanine nucleotide binding protein, alpha subunit
• G protein alpha subunit, helical insertion
• P-loop containing nucleoside triphosphate hydrolase
• G-protein alpha subunit

KeywordsUniProt

• ADP-ribosylation
• GTP-binding
• Magnesium
• Metal-binding
• Nucleotide-binding
• Transducer

InteractionsUniProt · HPA

Protein binding partners of GNA15 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• SOS2