Seroatlas · Human Serome Atlas

CPLANE2

Ciliogenesis and planar polarity effector 2

Also known as: C1orf89, CPLN2_HUMAN, MGC10731, RSG1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9BU20
Gene: CPLANE2
Ensembl: ENSG00000132881
Chromosome: 1
Canonical length: 258 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Nuclear bodies,Cytosol

OverviewNCBI Gene

Predicted to enable GTP binding activity. Predicted to be involved in cilium assembly; protein localization; and regulation of vesicle-mediated transport. Predicted to act upstream of or within several processes, including axoneme assembly; endocardial cushion fusion; and regulation of smoothened signaling pathway. Located in centriole; ciliary basal body; and ciliary transition zone. [provided by Alliance of Genome Resources, Apr 2025]

Canonical amino-acid sequenceUniProt

258 residues, UniProt reviewed canonical sequence.

>Q9BU20|CPLANE2
     1  MARPPVPGSV VVPNWHESAE GKEYLACILR KNRRRVFGLL ERPVLLPPVS IDTASYKIFV
    61  SGKSGVGKTA LVAKLAGLEV PVVHHETTGI QTTVVFWPAK LQASSRVVMF RFEFWDCGES
   121  ALKKFDHMLL ACMENTDAFL FLFSFTDRAS FEDLPGQLAR IAGEAPGVVR MVIGSKFDQY
   181  MHTDVPERDL TAFRQAWELP LLRVKSVPGR RLADGRTLDG RAGLADVAHI LNGLAEQLWH
   241  QDQVAAGLLP NPPESAPE

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CPLANE2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.28
Highest tissue expression: 9.5 nTPM

Expression across tissuesHPA

Tissue

cerebral cortex: 9.5 nTPM
basal ganglia: 8.4 nTPM
amygdala: 8.3 nTPM
hypothalamus: 8 nTPM
midbrain: 6.8 nTPM
fallopian tube: 6.3 nTPM

Single-cell type

respiratory ciliated cells: 9.8 nCPM
hepatic stellate cells: 6.5 nCPM
esophageal suprabasal cells: 6.3 nCPM
megakaryocytes: 6.2 nCPM
esophageal apical cells: 5.9 nCPM
fallopian tube ciliated cells: 5.6 nCPM

Immune cell

MAIT T-cell: 2.8 nTPM
gdT-cell: 2.2 nTPM
eosinophil: 1.9 nTPM
intermediate monocyte: 1.6 nTPM
T-reg: 1.5 nTPM
NK-cell: 1.4 nTPM

Brain region

hypothalamus: 35 nTPM
midbrain: 32 nTPM
thalamus: 30 nTPM
pons: 30 nTPM
amygdala: 29 nTPM
medulla oblongata: 28 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.63
gnomAD pLI: 0
DepMap mean gene effect: -0.13
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

Small GTPase
P-loop containing nucleoside triphosphate hydrolase
Ras family
Ciliogenesis and planar polarity effector 2

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CPLANE2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CPLANE2 as an antibody target. Whether an autoantibody or antibody against CPLANE2 could matter depends on whether native CPLANE2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CPLANE2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CPLANE2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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