Seroatlas · Human Serome Atlas

IQCN

IQ domain-containing protein N

Also known as: IQCN_HUMAN, KIAA1683

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9H0B3
Gene
IQCN
Ensembl
ENSG00000130518
Chromosome
19
Canonical length
1180 aa
Protein class
Human disease related genes, Predicted intracellular proteins
Subcellular location
Acrosome,Equatorial segment

OverviewNCBI Gene

Involved in spermatid development. Located in mitochondrion. Implicated in spermatogenic failure 78. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

1180 residues, UniProt reviewed canonical sequence.

>Q9H0B3|IQCN
     1  MTLQGRADLS GNQGNAAGRL ATVHEPVVTQ WAVHPPAPAH PSLLDKMEKA PPQPQHEGLK
    61  SKEHLPQQPA EGKTASRRVP RLRAVVESQA FKNILVDEMD MMHARAATLI QANWRGYWLR
   121  QKLISQMMAA KAIQEAWRRF NKRHILHSSK SLVKKTRAEE GDIPYHAPQQ VRFQHPEENR
   181  LLSPPIMVNK ETQFPSCDNL VLCRPQSSPL LQPPAAQGTP EPCVQGPHAA RVRGLAFLPH
   241  QTVTIRFPCP VSLDAKCQPC LLTRTIRSTC LVHIEGDSVK TKRVSARTNK ARAPETPLSR
   301  RYDQAVTRPS RAQTQGPVKA ETPKAPFQIC PGPMITKTLL QTYPVVSVTL PQTYPASTMT
   361  TTPPKTSPVP KVTIIKTPAQ MYPGPTVTKT APHTCPMPTM TKIQVHPTAS RTGTPRQTCP
   421  ATITAKNRPQ VSLLASIMKS LPQVCPGPAM AKTPPQMHPV TTPAKNPLQT CLSATMSKTS
   481  SQRSPVGVTK PSPQTRLPAM ITKTPAQLRS VATILKTLCL ASPTVANVKA PPQVAVAAGT
   541  PNTSGSIHEN PPKAKATVNV KQAAKVVKAS SPSYLAEGKI RCLAQPHPGT GVPRAAAELP
   601  LEAEKIKTGT QKQAKTDMAF KTSVAVEMAG APSWTKVAEE GDKPPHVYVP VDMAVTLPRG
   661  QLAAPLTNAS SQRHPPCLSQ RPLAAPLTKA SSQGHLPTEL TKTPSLAHLD TCLSKMHSQT
   721  HLATGAVKVQ SQAPLATCLT KTQSRGQPIT DITTCLIPAH QAADLSSNTH SQVLLTGSKV
   781  SNHACQRLGG LSAPPWAKPE DRQTQPQPHG HVPGKTTQGG PCPAACEVQG MLVPPMAPTG
   841  HSTCNVESWG DNGATRAQPS MPGQAVPCQE DTGPADAGVV GGQSWNRAWE PARGAASWDT
   901  WRNKAVVPPR RSGEPMVSMQ AAEEIRILAV ITIQAGVRGY LARRRIRLWH RGAMVIQATW
   961  RGYRVRRNLA HLCRATTTIQ SAWRGYSTRR DQARHWQMLH PVTWVELGSR AGVMSDRSWF
  1021  QDGRARTVSD HRCFQSCQAH ACSVCHSLSS RIGSPPSVVM LVGSSPRTCH TCGRTQPTRV
  1081  VQGMGQGTEG PGAVSWASAY QLAALSPRQP HRQDKAATAI QSAWRGFKIR QQMRQQQMAA
  1141  KIVQATWRGH HTRSCLKNTE ALLGPADPSA SSRHMHWPGI

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against IQCN can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.68
Highest tissue expression
30 nTPM

Expression across tissuesHPA

Tissue

  • testis: 30 nTPM
  • ovary: 3.6 nTPM
  • choroid plexus: 3.3 nTPM
  • fallopian tube: 3.1 nTPM
  • cervix: 3 nTPM
  • endometrium: 2.9 nTPM

Single-cell type

  • late spermatids: 142 nCPM
  • medullary thymic epithelial cells: 127 nCPM
  • early spermatids: 122 nCPM
  • transitional alveolar cells: 116 nCPM
  • alveolar cells type 2: 114 nCPM
  • salivary myoepithelial cells: 88 nCPM

Immune cell

  • neutrophil: 1.6 nTPM
  • naive B-cell: 0.6 nTPM
  • plasmacytoid DC: 0.6 nTPM
  • basophil: 0.5 nTPM
  • NK-cell: 0.4 nTPM
  • classical monocyte: 0.3 nTPM

Brain region

  • cerebellum: 35 nTPM
  • white matter: 21 nTPM
  • cerebral cortex: 19 nTPM
  • pons: 19 nTPM
  • thalamus: 18 nTPM
  • hypothalamus: 18 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about IQCN.

Disease | AllUniProt

Conditions IQCN is implicated in, by any mechanism.

Disease | GeneticClinVar

7 pathogenic / likely-pathogenic of 324 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

  • Spermatogenic failure 78

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.89
gnomAD pLI
0
DepMap mean gene effect
-0.12
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of IQCN in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads IQCN as an antibody target. Whether an autoantibody or antibody against IQCN could matter depends on whether native IQCN is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

IQCN is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label IQCN as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/IQCN. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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