Seroatlas · Human Serome Atlas

RAB1A

Ras-related protein Rab-1A

Also known as: RAB1, RAB1A_HUMAN, YPT1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P62820
Gene: RAB1A
Ensembl: ENSG00000138069
Chromosome: 2
Canonical length: 205 aa
Protein class: Enzymes, Plasma proteins, Predicted intracellular proteins
Subcellular location: Endoplasmic reticulum,Cytosol

OverviewNCBI Gene

This gene encodes a member of the Ras superfamily of GTPases. Members of the gene family cycle between inactive GDP-bound and active GTP-bound forms. This small GTPase controls vesicle traffic from the endoplasmic reticulum to the Golgi apparatus. Multiple alternatively spliced transcript variants have been identified for this gene which encode different protein isoforms. [provided by RefSeq, Oct 2008]

Canonical amino-acid sequenceUniProt

205 residues, UniProt reviewed canonical sequence.

>P62820|RAB1A
     1  MSSMNPEYDY LFKLLLIGDS GVGKSCLLLR FADDTYTESY ISTIGVDFKI RTIELDGKTI
    61  KLQIWDTAGQ ERFRTITSSY YRGAHGIIVV YDVTDQESFN NVKQWLQEID RYASENVNKL
   121  LVGNKCDLTT KKVVDYTTAK EFADSLGIPF LETSAKNATN VEQSFMTMAA EIKKRMGPGA
   181  TAGGAEKSNV KIQSTPVKQS GGGCC

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RAB1A can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.31
Highest tissue expression: 219 nTPM

Expression across tissuesHPA

Tissue

bone marrow: 219 nTPM
kidney: 181 nTPM
liver: 179 nTPM
epididymis: 170 nTPM
esophagus: 144 nTPM
blood vessel: 141 nTPM

Single-cell type

neutrophils: 2,121 nCPM
late spermatids: 1,610 nCPM
syncytiotrophoblasts: 1,105 nCPM
esophageal apical cells: 1,047 nCPM
neutrophil progenitors: 659 nCPM
hofbauer cells: 653 nCPM

Immune cell

neutrophil: 103 nTPM
basophil: 97 nTPM
intermediate monocyte: 86 nTPM
classical monocyte: 85 nTPM
non-classical monocyte: 81 nTPM
eosinophil: 79 nTPM

Brain region

choroid plexus: 117 nTPM
hypothalamus: 91 nTPM
pons: 91 nTPM
thalamus: 90 nTPM
white matter: 90 nTPM
midbrain: 85 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.47
gnomAD pLI: 0.82
gnomAD missense Z: 2.31
DepMap mean gene effect: -0.33
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of RAB1A in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RAB1A as an antibody target. Whether an autoantibody or antibody against RAB1A could matter depends on whether native RAB1A is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RAB1A is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label RAB1A as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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