Seroatlas · Human Serome Atlas

RAP1B

Ras-related protein Rap-1b

Also known as: DKFZp586H0723, K-REV, RAL1B, RAP1B_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P61224
Gene
RAP1B
Ensembl
ENSG00000127314
Chromosome
12
Canonical length
184 aa
Protein class
Enzymes, Plasma proteins, Predicted intracellular proteins, RAS pathway related proteins

OverviewNCBI Gene

This gene encodes a member of the RAS-like small GTP-binding protein superfamily. Members of this family regulate multiple cellular processes including cell adhesion and growth and differentiation. This protein localizes to cellular membranes and has been shown to regulate integrin-mediated cell signaling. This protein also plays a role in regulating outside-in signaling in platelets. Alternate splicing results in multiple transcript variants. Pseudogenes of this gene are found on chromosomes 3, 5, 6 and 9. [provided by RefSeq, Oct 2011]

Canonical amino-acid sequenceUniProt

184 residues, UniProt reviewed canonical sequence.

>P61224|RAP1B
     1  MREYKLVVLG SGGVGKSALT VQFVQGIFVE KYDPTIEDSY RKQVEVDAQQ CMLEILDTAG
    61  TEQFTAMRDL YMKNGQGFAL VYSITAQSTF NDLQDLREQI LRVKDTDDVP MILVGNKCDL
   121  EDERVVGKEQ GQNLARQWNN CAFLESSAKS KINVNEIFYD LVRQINRKTP VPGKARKKSS
   181  CQLL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RAP1B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.28
Highest tissue expression
261 nTPM

Expression across tissuesHPA

Tissue

  • bone marrow: 261 nTPM
  • lymph node: 197 nTPM
  • urinary bladder: 185 nTPM
  • blood vessel: 182 nTPM
  • tonsil: 169 nTPM
  • appendix: 157 nTPM

Single-cell type

  • megakaryocytes: 3,938 nCPM
  • platelets: 1,970 nCPM
  • neutrophils: 1,007 nCPM
  • neutrophil progenitors: 879 nCPM
  • megakaryocyte progenitors: 837 nCPM
  • urothelial cells: 803 nCPM

Immune cell

  • total PBMC: 822 nTPM
  • NK-cell: 471 nTPM
  • non-classical monocyte: 467 nTPM
  • intermediate monocyte: 408 nTPM
  • basophil: 401 nTPM
  • gdT-cell: 341 nTPM

Brain region

  • white matter: 118 nTPM
  • choroid plexus: 114 nTPM
  • hypothalamus: 111 nTPM
  • medulla oblongata: 108 nTPM
  • thalamus: 104 nTPM
  • pons: 98 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about RAP1B.

Disease | AllUniProt

Conditions RAP1B is implicated in, by any mechanism.

  • Thrombocytopenia 11 with multiple congenital anomalies and dysmorphic facies (THC11) MIM:620654

Disease | GeneticClinVar

6 pathogenic / likely-pathogenic of 57 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

  • Thrombocytopenia 11 with multiple congenital anomalies and dysmorphic facies
  • See cases
  • Squamous cell carcinoma of the skin

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.39
gnomAD pLI
0.91
gnomAD missense Z
2.6
DepMap mean gene effect
-0.46
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of RAP1B in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RAP1B as an antibody target. Whether an autoantibody or antibody against RAP1B could matter depends on whether native RAP1B is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RAP1B is annotated at the cell surface, where native RAP1B is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label RAP1B as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/RAP1B. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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