RAB10
Ras-related protein Rab-10
Also known as: RAB10_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- P61026
- Gene
- RAB10
- Ensembl
- ENSG00000084733
- Chromosome
- 2
- Canonical length
- 200 aa
- Protein class
- Enzymes, Predicted intracellular proteins
OverviewNCBI Gene
RAB10 belongs to the RAS (see HRAS; MIM 190020) superfamily of small GTPases. RAB proteins localize to exocytic and endocytic compartments and regulate intracellular vesicle trafficking (Bao et al., 1998 [PubMed 9918381]).[supplied by OMIM, Mar 2009]
Canonical amino-acid sequenceUniProt
200 residues, UniProt reviewed canonical sequence.
>P61026|RAB10
1 MAKKTYDLLF KLLLIGDSGV GKTCVLFRFS DDAFNTTFIS TIGIDFKIKT VELQGKKIKL
61 QIWDTAGQER FHTITTSYYR GAMGIMLVYD ITNGKSFENI SKWLRNIDEH ANEDVERMLL
121 GNKCDMDDKR VVPKGKGEQI AREHGIRFFE TSAKANINIE KAFLTLAEDI LRKTPVKEPN
181 SENVDISSGG GVTGWKSKCCLocalizationUniProt · AlphaFold · HPA
Whether an antibody against RAB10 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Other membrane
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.32
- Highest tissue expression
- 200 nTPM
Expression across tissuesHPA
Tissue
- skeletal muscle: 200 nTPM
- esophagus: 166 nTPM
- tongue: 107 nTPM
- vagina: 75 nTPM
- urinary bladder: 73 nTPM
- spinal cord: 69 nTPM
Single-cell type
- esophageal apical cells: 5,965 nCPM
- esophageal suprabasal cells: 1,549 nCPM
- urothelial cells: 1,472 nCPM
- suprabasal keratinocytes: 1,166 nCPM
- neutrophils: 821 nCPM
- neutrophil progenitors: 721 nCPM
Immune cell
- non-classical monocyte: 153 nTPM
- intermediate monocyte: 135 nTPM
- total PBMC: 81 nTPM
- classical monocyte: 76 nTPM
- myeloid DC: 70 nTPM
- basophil: 58 nTPM
Brain region
- white matter: 98 nTPM
- medulla oblongata: 82 nTPM
- spinal cord: 77 nTPM
- cerebellum: 70 nTPM
- basal ganglia: 69 nTPM
- hypothalamus: 68 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 0.27
- gnomAD pLI
- 0.97
- gnomAD missense Z
- 2.63
- DepMap mean gene effect
- -0.44
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
- antigen processing and presentation
- axonogenesis
- cellular response to insulin stimulus
- endoplasmic reticulum tubular network organization
- endosomal transport
- establishment of neuroblast polarity
- establishment of protein localization to endoplasmic reticulum membrane
- establishment of protein localization to membrane
- exocytosis
- Golgi to plasma membrane protein transport
- Golgi to plasma membrane transport
- negative regulation of motile cilium assembly
- polarized epithelial cell differentiation
- protein localization to basolateral plasma membrane
- protein localization to plasma membrane
- regulated exocytosis
- vesicle-mediated transport
Molecular functions
- cadherin binding involved in cell-cell adhesion
- G protein activity
- GDP binding
- GTP binding
- myosin V binding
Cellular components
- adherens junction
- cilium
- cytoplasmic vesicle membrane
- cytosol
- endoplasmic reticulum membrane
- endoplasmic reticulum tubular network
- endosome
- endosome membrane
- exocytic vesicle
- extracellular exosome
- focal adhesion
- Golgi apparatus
- Golgi membrane
- insulin-responsive compartment
- lysosome
- membrane
- perinuclear region of cytoplasm
- phagocytic vesicle membrane
- plasma membrane
- recycling endosome
- recycling endosome membrane
- secretory granule membrane
- secretory vesicle
- trans-Golgi network
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
InteractionsUniProt · HPA
Protein binding partners of RAB10 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads RAB10 as an antibody target. Whether an autoantibody or antibody against RAB10 could matter depends on whether native RAB10 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
RAB10 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label RAB10 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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