Seroatlas · Human Serome Atlas

IQANK1

IQ motif and ankyrin repeat domain-containing protein 1

Also known as: FAM83H-AS1, IQAK1_HUMAN, onco-lncRNA-3

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
A8MXQ7
Gene
IQANK1
Ensembl
ENSG00000203499
Chromosome
8
Canonical length
560 aa
Protein class
Predicted intracellular proteins

OverviewNCBI Gene

No narrative summary is available for IQANK1 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

560 residues, UniProt reviewed canonical sequence.

>A8MXQ7|IQANK1
     1  MDSKKGRPKA AAGKWQTLHP GPKTRAAAGK PGENRPPQRK AGWQAREPAS AESPQAPTGP
    61  AEDRAARAIQ GAFRQLRARR ELARRREERR EYLEQMETPQ KEAYLAPVRR EQEAARRLRE
   121  QEEAAQRERR EELQRRRRLL DAAFDGDVGE IRAVLKEVEQ LLTREGVGHD EAGEARRLQR
   181  RVALAECEDS YGNTPLSEAA AGGQPLAIQL RAELGASPNS KGAFGPTPLY RAAFGGHLAA
   241  VEVLLKLGAD PRVYAEDGST PERVASLDTV VSVLRSWDLS LTEAMLQNME AEQQRRAQEA
   301  QRHKEAEAER CGSMTLKVQQ LTREQQQCHK ELQQAYCELS RRISEHDQCE WRCMDKTKLT
   361  LQAIKDTEAQ VDRLRQEAQK AEEALAMARL ELREQTQEGE EEAPGLKCQV TELHDVLMKD
   421  VGNRIRADGR WPLVIDPLGQ AATFLRYQDT NYVDTVNPEP LRPETMWLAL LGALRYGKPL
   481  VFDLREEDLF PVVQRQLEAV QERYLSLLRP TDGPEYSPTQ FQEQRLEHFR LFFVTKVQWP
   541  PAEQLQVLLP VRVQLPGTGL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against IQANK1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Unknown
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.37
Highest tissue expression
40 nTPM

Expression across tissuesHPA

Tissue

  • esophagus: 40 nTPM
  • skin: 27 nTPM
  • epididymis: 20 nTPM
  • vagina: 18 nTPM
  • cervix: 15 nTPM
  • fallopian tube: 8.6 nTPM

Single-cell type

  • ependymal cells: 60 nCPM
  • papillary tip epithelial cells: 40 nCPM
  • renal collecting duct principal cells: 35 nCPM
  • renal connecting tubule cells: 18 nCPM
  • choroid plexus epithelial cells: 18 nCPM
  • loop of henle epithelial cells: 17 nCPM

Immune cell

  • neutrophil: 1.4 nTPM
  • basophil: 0.8 nTPM
  • naive B-cell: 0.4 nTPM
  • classical monocyte: 0.3 nTPM
  • memory B-cell: 0.3 nTPM
  • NK-cell: 0.3 nTPM

Brain region

  • midbrain: 9.7 nTPM
  • choroid plexus: 8.3 nTPM
  • medulla oblongata: 6.9 nTPM
  • cerebral cortex: 5.7 nTPM
  • hippocampal formation: 5.7 nTPM
  • cerebellum: 5.5 nTPM

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads IQANK1 as an antibody target. Whether an autoantibody or antibody against IQANK1 could matter depends on whether native IQANK1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

IQANK1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label IQANK1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/IQANK1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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