RABL2B

Protein identityUniProt · HPA

UniProt accession

Q9UNT1

Gene

RABL2B

Ensembl

ENSG00000079974

Chromosome

22

Canonical length

228 aa

Protein class

Predicted intracellular proteins

Subcellular location

Vesicles,Centrosome,Basal body

OverviewNCBI Gene

This gene is a member of the RAB gene family which belongs to the RAS GTPase superfamily. The proteins in the family of RAS-related signaling molecules are small GTP-binding proteins that play important roles in the regulation of exocytotic and endocytotic pathways. This gene maps to the site of an ancestral telomere fusion event and may be a subtelomeric gene. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2015]

Canonical amino-acid sequenceUniProt

228 residues, UniProt reviewed canonical sequence.

>Q9UNT1|RABL2B
     1  MAEDKTKPSE LDQGKYDADD NVKIICLGDS AVGKSKLMER FLMDGFQPQQ LSTYALTLYK
    61  HTATVDGRTI LVDFWDTAGQ ERFQSMHASY YHKAHACIMV FDVQRKVTYR NLSTWYTELR
   121  EFRPEIPCIV VANKIDDINV TQKSFNFAKK FSLPLYFVSA ADGTNVVKLF NDAIRLAVSY
   181  KQNSQDFMDE IFQELENFSL EQEEEDVPDQ EQSSSIETPS EEAASPHS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RABL2B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.36

Highest tissue expression

85 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

1.5

gnomAD pLI

0

gnomAD missense Z

-0.02

DepMap mean gene effect

-0.18

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• cilium assembly
• intracellular protein transport
• intraciliary transport

Molecular functions

• G protein activity
• GTP binding
• GTPase activity

Cellular components

• centriole
• ciliary basal body
• cytoplasm
• endomembrane system
• pericentriolar material

Protein domainsUniProt · Pfam · InterPro

• Small GTPase
• Small GTP-binding domain
• P-loop containing nucleoside triphosphate hydrolase
• Rab-like protein 2
• Ras family

KeywordsUniProt

• Cell projection
• Cilium
• Cilium biogenesis/degradation
• Cytoplasm
• Cytoskeleton
• GTP-binding
• Hydrolase
• Magnesium
• Metal-binding
• Nucleotide-binding

InteractionsUniProt · HPA

Protein binding partners of RABL2B in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• CEP19