Seroatlas · Human Serome Atlas

KIF3A

Kinesin-like protein KIF3A

Also known as: FLA10, KIF3A_HUMAN, KLP-20

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9Y496
Gene
KIF3A
Ensembl
ENSG00000131437
Chromosome
5
Canonical length
699 aa
Protein class
Predicted intracellular proteins
Subcellular location
Nucleoplasm,Primary cilium,Basal body,Cytosol

OverviewNCBI Gene

Enables protein phosphatase binding activity; small GTPase binding activity; and spectrin binding activity. Involved in protein localization to cell junction and protein transport. Located in centriole; centrosome; and spindle microtubule. Part of kinesin II complex. Biomarker of silicosis. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

699 residues, UniProt reviewed canonical sequence.

>Q9Y496|KIF3A
     1  MPINKSEKPE SCDNVKVVVR CRPLNEREKS MCYKQAVSVD EMRGTITVHK TDSSNEPPKT
    61  FTFDTVFGPE SKQLDVYNLT ARPIIDSVLE GYNGTIFAYG QTGTGKTFTM EGVRAIPELR
   121  GIIPNSFAHI FGHIAKAEGD TRFLVRVSYL EIYNEEVRDL LGKDQTQRLE VKERPDVGVY
   181  IKDLSAYVVN NADDMDRIMT LGHKNRSVGA TNMNEHSSRS HAIFTITIEC SEKGIDGNMH
   241  VRMGKLHLVD LAGSERQAKT GATGQRLKEA TKINLSLSTL GNVISALVDG KSTHVPYRNS
   301  KLTRLLQDSL GGNSKTMMCA NIGPADYNYD ETISTLRYAN RAKNIKNKAR INEDPKDALL
   361  RQFQKEIEEL KKKLEEGEEI SGSDISGSEE DDDEEGEVGE DGEKRKKRRG KKKVSPDKMI
   421  EMQAKIDEER KALETKLDME EEERNKARAE LEKREKDLLK AQQEHQSLLE KLSALEKKVI
   481  VGGVDLLAKA EEQEKLLEES NMELEERRKR AEQLRRELEE KEQERLDIEE KYTSLQEEAQ
   541  GKTKKLKKVW TMLMAAKSEM ADLQQEHQRE IEGLLENIRQ LSRELRLQML IIDNFIPRDY
   601  QEMIENYVHW NEDIGEWQLK CVAYTGNNMR KQTPVPDKKE KDPFEVDLSH VYLAYTEESL
   661  RQSLMKLERP RTSKGKARPK TGRRKRSAKP ETVIDSLLQ

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against KIF3A can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.37
Highest tissue expression
40 nTPM

Expression across tissuesHPA

Tissue

  • cerebral cortex: 40 nTPM
  • retina: 31 nTPM
  • testis: 20 nTPM
  • cerebellum: 20 nTPM
  • hypothalamus: 19 nTPM
  • hippocampal formation: 15 nTPM

Single-cell type

  • retinal horizontal cells: 220 nCPM
  • respiratory ciliated cells: 205 nCPM
  • gonadotrophs: 203 nCPM
  • other brain neurons: 195 nCPM
  • brain excitatory neurons: 194 nCPM
  • brain inhibitory neurons: 190 nCPM

Immune cell

  • basophil: 68 nTPM
  • naive CD8 T-cell: 7.1 nTPM
  • MAIT T-cell: 6.9 nTPM
  • memory B-cell: 6.7 nTPM
  • memory CD4 T-cell: 6.6 nTPM
  • naive CD4 T-cell: 6.4 nTPM

Brain region

  • cerebral cortex: 104 nTPM
  • pons: 90 nTPM
  • hypothalamus: 87 nTPM
  • basal ganglia: 81 nTPM
  • midbrain: 80 nTPM
  • medulla oblongata: 78 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.34
gnomAD pLI
0.9
gnomAD missense Z
3.09
DepMap mean gene effect
-0.09
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of KIF3A in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads KIF3A as an antibody target. Whether an autoantibody or antibody against KIF3A could matter depends on whether native KIF3A is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

KIF3A is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label KIF3A as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/KIF3A. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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