MTG1
Mitochondrial ribosome-associated GTPase 1
Also known as: GTPBP7, MTG1_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q9BT17
- Gene
- MTG1
- Ensembl
- ENSG00000148824
- Chromosome
- 10
- Canonical length
- 334 aa
- Protein class
- Predicted intracellular proteins
- Subcellular location
- Mitochondria
OverviewNCBI Gene
Enables GTPase activity. Involved in mitochondrial large ribosomal subunit assembly; regulation of mitochondrial translation; and regulation of respiratory system process. Located in mitochondrial inner membrane; mitochondrial ribosome; and nucleoplasm. Is active in mitochondrial matrix. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
334 residues, UniProt reviewed canonical sequence.
>Q9BT17|MTG1
1 MRLTPRALCS AAQAAWRENF PLCGRDVARW FPGHMAKGLK KMQSSLKLVD CIIEVHDARI
61 PLSGRNPLFQ ETLGLKPHLL VLNKMDLADL TEQQKIMQHL EGEGLKNVIF TNCVKDENVK
121 QIIPMVTELI GRSHRYHRKE NLEYCIMVIG VPNVGKSSLI NSLRRQHLRK GKATRVGGEP
181 GITRAVMSKI QVSERPLMFL LDTPGVLAPR IESVETGLKL ALCGTVLDHL VGEETMADYL
241 LYTLNKHQRF GYVQHYGLGS ACDNVERVLK SVAVKLGKTQ KVKVLTGTGN VNIIQPNYPA
301 AARDFLQTFR RGLLGSVMLD LDVLRGHPPA ETLPLocalizationUniProt · AlphaFold · HPA
Whether an antibody against MTG1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Other membrane
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.28
- Highest tissue expression
- 48 nTPM
Expression across tissuesHPA
Tissue
- liver: 48 nTPM
- testis: 32 nTPM
- kidney: 29 nTPM
- adrenal gland: 28 nTPM
- spleen: 26 nTPM
- choroid plexus: 25 nTPM
Single-cell type
- cytotrophoblasts: 81 nCPM
- late spermatids: 80 nCPM
- migrating cytotrophoblasts: 78 nCPM
- extravillous trophoblasts: 72 nCPM
- late primary spermatocytes: 67 nCPM
- hepatocytes: 59 nCPM
Immune cell
- naive B-cell: 49 nTPM
- NK-cell: 48 nTPM
- non-classical monocyte: 43 nTPM
- plasmacytoid DC: 43 nTPM
- memory B-cell: 42 nTPM
- intermediate monocyte: 36 nTPM
Brain region
- choroid plexus: 14 nTPM
- cerebellum: 13 nTPM
- medulla oblongata: 13 nTPM
- thalamus: 12 nTPM
- pons: 11 nTPM
- midbrain: 11 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 0.72
- gnomAD pLI
- 0.01
- gnomAD missense Z
- -0.52
- DepMap mean gene effect
- -0.18
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
- mitochondrial large ribosomal subunit assembly
- regulation of mitochondrial translation
- regulation of respiratory system process
Molecular functions
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads MTG1 as an antibody target. Whether an autoantibody or antibody against MTG1 could matter depends on whether native MTG1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
MTG1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label MTG1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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