ARL17A
ADP-ribosylation factor-like protein 17
Also known as: ARF1P2, ARL17, ARL17_HUMAN, ARL17B, ARL17P1
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q8IVW1
- Gene
- ARL17A
- Ensembl
- ENSG00000185829
- Chromosome
- 17
- Canonical length
- 177 aa
- Protein class
- Predicted intracellular proteins
- Subcellular location
- Nucleoplasm
OverviewNCBI Gene
Predicted to enable GTP binding activity. Predicted to be involved in intracellular protein transport and vesicle-mediated transport. Predicted to be located in Golgi apparatus. Predicted to be active in cytoplasm and plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
177 residues, UniProt reviewed canonical sequence.
>Q8IVW1|ARL17A
1 MGNIFEKLFK SLLGKKKMRI LILSLDTAGK TTILYKLKLG ETVPAVPTVG FCVETVEYKN
61 NTFAVWDVGS HFKIRPLWQH FFQNTKGARS PGSTHQGSLA SGVLPIKCSH VEFGMWKGGR
121 SHPFLPHSSR CAGSGGQLDS ILPHQSPAWG PWGCKDLSSG FPSFLTSSIL WKSAVVKLocalizationUniProt · AlphaFold · HPA
Whether an antibody against ARL17A can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Cell surface
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.59
- Highest tissue expression
- 38 nTPM
Expression across tissuesHPA
Tissue
- epididymis: 38 nTPM
- retina: 32 nTPM
- choroid plexus: 22 nTPM
- parathyroid gland: 21 nTPM
- tonsil: 21 nTPM
- tongue: 19 nTPM
Single-cell type
- distal convoluted tubule cells: 52 nCPM
- renal collecting duct intercalated cells: 42 nCPM
- renal connecting tubule cells: 40 nCPM
- renal collecting duct principal cells: 39 nCPM
- loop of henle epithelial cells: 38 nCPM
- papillary tip epithelial cells: 36 nCPM
Immune cell
- basophil: 15 nTPM
- plasmacytoid DC: 12 nTPM
- naive B-cell: 12 nTPM
- naive CD4 T-cell: 11 nTPM
- naive CD8 T-cell: 11 nTPM
- gdT-cell: 9.4 nTPM
Brain region
- cerebellum: 157 nTPM
- hypothalamus: 99 nTPM
- white matter: 99 nTPM
- cerebral cortex: 94 nTPM
- thalamus: 92 nTPM
- pons: 91 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.84
- gnomAD pLI
- 0.34
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
Molecular functions
Cellular components
Protein domainsUniProt · Pfam · InterPro
- Small GTPase superfamily, ARF/SAR type
- Small GTPase superfamily, ARF type
- P-loop containing nucleoside triphosphate hydrolase
- ADP-ribosylation factor family
- ADP-ribosylation factor-like protein 17, C-terminal
- ADP-ribosylation factor-like protein 17
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads ARL17A as an antibody target. Whether an autoantibody or antibody against ARL17A could matter depends on whether native ARL17A is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
ARL17A is annotated at the cell surface, where native ARL17A is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.
Annotation status
The present source text does not explicitly label ARL17A as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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