DHX57

Protein identityUniProt · HPA

UniProt accession

Q6P158

Gene

DHX57

Ensembl

ENSG00000163214

Chromosome

2

Canonical length

1386 aa

Protein class

Enzymes, Predicted intracellular proteins

Subcellular location

Cytosol

OverviewNCBI Gene

Enables RNA binding activity. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

1386 residues, UniProt reviewed canonical sequence.

>Q6P158|DHX57
     1  MSSSVRRKGK PGKGGGKGSS RGGRGGRSHA SKSHGSGGGG GGGGGGGGGN RKASSRIWDD
    61  GDDFCIFSES RRPSRPSNSN ISKGESRPKW KPKAKVPLQT LHMTSENQEK VKALLRDLQE
   121  QDADAGSERG LSGEEEDDEP DCCNDERYWP AGQEPSLVPD LDPLEYAGLA SVEPYVPEFT
   181  VSPFAVQKLS RYGFNTERCQ AVLRMCDGDV GASLEHLLTQ CFSETFGERM KISEAVNQIS
   241  LDECMEQRQE EAFALKSICG EKFIERIQNR VWTIGLELEY LTSRFRKSKP KESTKNVQEN
   301  SLEICKFYLK GNCKFGSKCR FKHEVPPNQI VGRIERSVDD SHLNAIEDAS FLYELEIRFS
   361  KDHKYPYQAP LVAFYSTNEN LPLACRLHIS EFLYDKALTF AETSEPVVYS LITLLEEESE
   421  IVKLLTNTHH KYSDPPVNFL PVPSRTRINN PACHKTVIPN NSFVSNQIPE VEKASESEES
   481  DEDDGPAPVI VENESYVNLK KKISKRYDWQ AKSVHAENGK ICKQFRMKQA SRQFQSILQE
   541  RQSLPAWEER ETILNLLRKH QVVVISGMTG CGKTTQIPQF ILDDSLNGPP EKVANIICTQ
   601  PRRISAISVA ERVAKERAER VGLTVGYQIR LESVKSSATR LLYCTTGVLL RRLEGDTALQ
   661  GVSHIIVDEV HERTEESDFL LLVLKDIVSQ RPGLQVILMS ATLNAELFSD YFNSCPVITI
   721  PGRTFPVDQF FLEDAIAVTR YVLQDGSPYM RSMKQISKEK LKARRNRTAF EEVEEDLRLS
   781  LHLQDQDSVK DAVPDQQLDF KQLLARYKGV SKSVIKTMSI MDFEKVNLEL IEALLEWIVD
   841  GKHSYPPGAI LVFLPGLAEI KMLYEQLQSN SLFNNRRSNR CVIHPLHSSL SSEEQQAVFV
   901  KPPAGVTKII ISTNIAETSI TIDDVVYVID SGKMKEKRYD ASKGMESLED TFVSQANALQ
   961  RKGRAGRVAS GVCFHLFTSH HYNHQLLKQQ LPEIQRVPLE QLCLRIKILE MFSAHNLQSV
  1021  FSRLIEPPHT DSLRASKIRL RDLGALTPDE RLTPLGYHLA SLPVDVRIGK LMLFGSIFRC
  1081  LDPALTIAAS LAFKSPFVSP WDKKEEANQK KLEFAFANSD YLALLQAYKG WQLSTKEGVR
  1141  ASYNYCRQNF LSGRVLQEMA SLKRQFTELL SDIGFAREGL RAREIEKRAQ GGDGVLDATG
  1201  EEANSNAENP KLISAMLCAA LYPNVVQVKS PEGKFQKTST GAVRMQPKSA ELKFVTKNDG
  1261  YVHIHPSSVN YQVRHFDSPY LLYHEKIKTS RVFIRDCSMV SVYPLVLFGG GQVNVQLQRG
  1321  EFVVSLDDGW IRFVAASHQV AELVKELRCE LDQLLQDKIK NPSIDLCTCP RGSRIISTIV
  1381  KLVTTQ

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against DHX57 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Unknown

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.33

Highest tissue expression

22 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.68

gnomAD pLI

0

gnomAD missense Z

-0.96

DepMap mean gene effect

-0.13

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 8% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• positive regulation of translation

Molecular functions

• ATP binding
• ATP hydrolysis activity
• helicase activity
• RNA binding
• RNA helicase activity
• RNA polymerase binding
• zinc ion binding

Protein domainsUniProt · Pfam · InterPro

• Zinc finger, CCCH-type
• Helicase, C-terminal domain-like
• DNA/RNA helicase, ATP-dependent, DEAH-box type, conserved site
• RWD domain
• Helicase-associated domain
• UBA-like superfamily
• DEAD/DEAH-box helicase domain
• DEAD-box helicase, OB fold
• Helicase superfamily 1/2, ATP-binding domain
• Ubiquitin-associated domain
• P-loop containing nucleoside triphosphate hydrolase
• Zinc finger, CCCH-type superfamily
• Helicase associated domain (HA2), winged-helix domain
• RNA helicase, C-terminal domain
• DEAD/DEAH box helicase
• Helicase conserved C-terminal domain
• Zinc finger C-x8-C-x5-C-x3-H type (and similar)
• Helicase associated domain (HA2), winged-helix
• RWD domain
• Oligonucleotide/oligosaccharide-binding (OB)-fold
• Helicase associated domain (HA2), ratchet-like
• C-terminal domain in RNA helicases
• DHX57, UBA domain

KeywordsUniProt

• ATP-binding
• Coiled coil
• Helicase
• Hydrolase
• Metal-binding
• Nucleotide-binding
• Phosphoprotein
• Zinc
• Zinc-finger

InteractionsUniProt · HPA

Protein binding partners of DHX57 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• LIN28A