Seroatlas · Human Serome Atlas

RAB30

Ras-related protein Rab-30

Also known as: RAB30_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q15771
Gene: RAB30
Ensembl: ENSG00000137502
Chromosome: 11
Canonical length: 203 aa
Protein class: Predicted intracellular proteins
Subcellular location: Vesicles

OverviewNCBI Gene

Predicted to enable GTP binding activity and GTPase activity. Involved in Golgi organization. Located in Golgi cisterna; cis-Golgi network; and trans-Golgi network. [provided by Alliance of Genome Resources, Apr 2025]

Canonical amino-acid sequenceUniProt

203 residues, UniProt reviewed canonical sequence.

>Q15771|RAB30
     1  MSMEDYDFLF KIVLIGNAGV GKTCLVRRFT QGLFPPGQGA TIGVDFMIKT VEINGEKVKL
    61  QIWDTAGQER FRSITQSYYR SANALILTYD ITCEESFRCL PEWLREIEQY ASNKVITVLV
   121  GNKIDLAERR EVSQQRAEEF SEAQDMYYLE TSAKESDNVE KLFLDLACRL ISEARQNTLV
   181  NNVSSPLPGE GKSISYLTCC NFN

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RAB30 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.31
Highest tissue expression: 27 nTPM

Expression across tissuesHPA

Tissue

tonsil: 27 nTPM
small intestine: 20 nTPM
lymph node: 18 nTPM
duodenum: 17 nTPM
bone marrow: 14 nTPM
appendix: 13 nTPM

Single-cell type

plasma cells: 211 nCPM
b-cells: 166 nCPM
oligodendrocytes: 128 nCPM
myonuclei: 91 nCPM
fibro-adipogenic progenitors: 77 nCPM
adrenal cortex cells: 65 nCPM

Immune cell

naive B-cell: 55 nTPM
memory B-cell: 55 nTPM
naive CD4 T-cell: 11 nTPM
naive CD8 T-cell: 10 nTPM
T-reg: 9.5 nTPM
total PBMC: 6.2 nTPM

Brain region

white matter: 116 nTPM
medulla oblongata: 95 nTPM
basal ganglia: 92 nTPM
hypothalamus: 88 nTPM
pons: 83 nTPM
thalamus: 81 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.38
gnomAD pLI: 0.92
gnomAD missense Z: 1.94
DepMap mean gene effect: 0.06
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of RAB30 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

USP6NL

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RAB30 as an antibody target. Whether an autoantibody or antibody against RAB30 could matter depends on whether native RAB30 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RAB30 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label RAB30 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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