Seroatlas · Human Serome Atlas

UCKL1

Uridine-cytidine kinase-like 1

Also known as: FLJ20517, UCKL1_HUMAN, URKL1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9NWZ5
Gene: UCKL1
Ensembl: ENSG00000198276
Chromosome: 20
Canonical length: 548 aa
Protein class: Enzymes, Metabolic proteins, Predicted intracellular proteins
Subcellular location: Endoplasmic reticulum

OverviewNCBI Gene

The protein encoded by this gene is a uridine kinase. Uridine kinases catalyze the phosphorylation of uridine to uridine monophosphate. This protein has been shown to bind to Epstein-Barr nuclear antigen 3 as well as natural killer lytic-associated molecule. Ubiquitination of this protein is enhanced by the presence of natural killer lytic-associated molecule. In addition, protein levels decrease in the presence of natural killer lytic-associated molecule, suggesting that association with natural killer lytic-associated molecule results in ubiquitination and subsequent degradation of this protein. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2014]

Canonical amino-acid sequenceUniProt

548 residues, UniProt reviewed canonical sequence.

>Q9NWZ5|UCKL1
     1  MAAPPARADA DPSPTSPPTA RDTPGRQAEK SETACEDRSN AESLDRLLPP VGTGRSPRKR
    61  TTSQCKSEPP LLRTSKRTIY TAGRPPWYNE HGTQSKEAFA IGLGGGSASG KTTVARMIIE
   121  ALDVPWVVLL SMDSFYKVLT EQQQEQAAHN NFNFDHPDAF DFDLIISTLK KLKQGKSVKV
   181  PIYDFTTHSR KKDWKTLYGA NVIIFEGIMA FADKTLLELL DMKIFVDTDS DIRLVRRLRR
   241  DISERGRDIE GVIKQYNKFV KPSFDQYIQP TMRLADIVVP RGSGNTVAID LIVQHVHSQL
   301  EERELSVRAA LASAHQCHPL PRTLSVLKST PQVRGMHTII RDKETSRDEF IFYSKRLMRL
   361  LIEHALSFLP FQDCVVQTPQ GQDYAGKCYA GKQITGVSIL RAGETMEPAL RAVCKDVRIG
   421  TILIQTNQLT GEPELHYLRL PKDISDDHVI LMDCTVSTGA AAMMAVRVLL DHDVPEDKIF
   481  LLSLLMAEMG VHSVAYAFPR VRIITTAVDK RVNDLFRIIP GIGNFGDRYF GTDAVPDGSD
   541  EEEVAYTG

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against UCKL1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.33
Highest tissue expression: 100 nTPM

Expression across tissuesHPA

Tissue

cerebellum: 100 nTPM
ovary: 73 nTPM
spleen: 62 nTPM
skeletal muscle: 58 nTPM
thyroid gland: 57 nTPM
kidney: 56 nTPM

Single-cell type

rod photoreceptor cells: 122 nCPM
cone photoreceptor cells: 97 nCPM
esophageal apical cells: 68 nCPM
cardiomyocytes: 61 nCPM
myonuclei: 44 nCPM
syncytiotrophoblasts: 41 nCPM

Immune cell

memory B-cell: 31 nTPM
non-classical monocyte: 22 nTPM
MAIT T-cell: 21 nTPM
T-reg: 21 nTPM
intermediate monocyte: 20 nTPM
gdT-cell: 18 nTPM

Brain region

cerebellum: 51 nTPM
white matter: 48 nTPM
cerebral cortex: 39 nTPM
choroid plexus: 36 nTPM
medulla oblongata: 35 nTPM
pons: 34 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.33
gnomAD pLI: 0
gnomAD missense Z: 2.32
DepMap mean gene effect: 0.09
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 15% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of UCKL1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads UCKL1 as an antibody target. Whether an autoantibody or antibody against UCKL1 could matter depends on whether native UCKL1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

UCKL1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label UCKL1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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