Seroatlas · Human Serome Atlas

RAB25

Ras-related protein Rab-25

Also known as: CATX-8, RAB25_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P57735
Gene: RAB25
Ensembl: ENSG00000132698
Chromosome: 1
Canonical length: 213 aa
Protein class: Cancer-related genes, Predicted intracellular proteins
Subcellular location: Plasma membrane

OverviewNCBI Gene

The protein encoded by this gene is a member of the RAS superfamily of small GTPases. The encoded protein is involved in membrane trafficking and cell survival. This gene has been found to be a tumor suppressor and an oncogene, depending on the context. Two variants, one protein-coding and the other not, have been found for this gene. [provided by RefSeq, Nov 2015]

Canonical amino-acid sequenceUniProt

213 residues, UniProt reviewed canonical sequence.

>P57735|RAB25
     1  MGNGTEEDYN FVFKVVLIGE SGVGKTNLLS RFTRNEFSHD SRTTIGVEFS TRTVMLGTAA
    61  VKAQIWDTAG LERYRAITSA YYRGAVGALL VFDLTKHQTY AVVERWLKEL YDHAEATIVV
   121  MLVGNKSDLS QAREVPTEEA RMFAENNGLL FLETSALDST NVELAFETVL KEIFAKVSKQ
   181  RQNSIRTNAI TLGSAQAGQE PGPGEKRACC ISL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RAB25 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.33
Highest tissue expression: 407 nTPM

Expression across tissuesHPA

Tissue

esophagus: 407 nTPM
skin: 203 nTPM
vagina: 145 nTPM
cervix: 112 nTPM
salivary gland: 99 nTPM
colon: 81 nTPM

Single-cell type

esophageal apical cells: 3,927 nCPM
esophageal suprabasal cells: 1,504 nCPM
esophageal basal cells: 358 nCPM
suprabasal keratinocytes: 340 nCPM
gastric progenitor cells: 276 nCPM
urothelial cells: 215 nCPM

Immune cell

MAIT T-cell: 1.3 nTPM
naive CD4 T-cell: 1.2 nTPM
naive CD8 T-cell: 1.1 nTPM
memory CD4 T-cell: 1 nTPM
T-reg: 0.3 nTPM
memory CD8 T-cell: 0.2 nTPM

Brain region

white matter: 0.7 nTPM
cerebellum: 0.6 nTPM
spinal cord: 0.4 nTPM
cerebral cortex: 0.3 nTPM
amygdala: 0.2 nTPM
basal ganglia: 0.2 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.55
gnomAD pLI: 0
gnomAD missense Z: 0.82
DepMap mean gene effect: -0.13
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 8% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of RAB25 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RAB25 as an antibody target. Whether an autoantibody or antibody against RAB25 could matter depends on whether native RAB25 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RAB25 is annotated at the cell surface, where native RAB25 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label RAB25 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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