MPP4

Protein identityUniProt · HPA

UniProt accession

Q96JB8

Gene

MPP4

Ensembl

ENSG00000082126

Chromosome

2

Canonical length

637 aa

Protein class

Predicted intracellular proteins

Subcellular location

Actin filaments,Cytosol

OverviewNCBI Gene

This gene encodes a member of the membrane-associated guanylate kinase (MAGUK) protein family, with an N-terminal PDZ domain, a central src homology 3 region (SH3), and a C-terminal guanylate kinase-like (GUK) domain. The protein is localized to the outer limiting membrane in the retina, and is thought to function in photoreceptor polarity and the organization of specialized intercellular junctions. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

637 residues, UniProt reviewed canonical sequence.

>Q96JB8|MPP4
     1  MIQSDKGADP PDKKDMKLST ATNPQNGLSQ ILRLVLQELS LFYGRDVNGV CLLYDLLHSP
    61  WLQALLKIYD CLQEFKEKKL VPATPHAQVL SYEVVELLRE TPTSPEIQEL RQMLQAPHFK
   121  ALLSAHDTIA QKDFEPLLPP LPDNIPESEE AMRIVCLVKN QQPLGATIKR HEMTGDILVA
   181  RIIHGGLAER SGLLYAGDKL VEVNGVSVEG LDPEQVIHIL AMSRGTIMFK VVPVSDPPVN
   241  SQQMVYVRAM TEYWPQEDPD IPCMDAGLPF QKGDILQIVD QNDALWWQAR KISDPATCAG
   301  LVPSNHLLKR KQREFWWSQP YQPHTCLKST LSISMEEEDD MKIDEKCVEA DEETFESEEL
   361  SEDKEEFVGY GQKFFIAGFR RSMRLCRRKS HLSPLHASVC CTGSCYSAVG APYEEVVRYQ
   421  RRPSDKYRLI VLMGPSGVGV NELRRQLIEF NPSHFQSAVP HTTRTKKSYE MNGREYHYVS
   481  KETFENLIYS HRMLEYGEYK GHLYGTSVDA VQTVLVEGKI CVMDLEPQDI QGVRTHELKP
   541  YVIFIKPSNM RCMKQSRKNA KVITDYYVDM KFKDEDLQEM ENLAQRMETQ FGQFFDHVIV
   601  NDSLHDACAQ LLSAIQKAQE EPQWVPATWI SSDTESQ

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MPP4 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.38

Highest tissue expression

265 nTPM

Expression across tissuesHPA

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about MPP4.

Disease | GeneticClinVar

1 pathogenic / likely-pathogenic of 111 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

• 7 conditions

Disease | ImmuneIEDB

Conditions an epitope on MPP4 was assayed in.

• ankylosing spondylitis T cell
• autoimmune uveitis T cell

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

1.06

gnomAD pLI

0

gnomAD missense Z

0.45

DepMap mean gene effect

0.11

DepMap dependency class

none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• protein localization to synapse

Cellular components

• actin cytoskeleton
• adherens junction
• cytosol
• plasma membrane
• protein-containing complex

Protein domainsUniProt · Pfam · InterPro

• SH3 domain
• PDZ domain
• L27 domain
• Guanylate kinase-like domain
• Guanylate kinase/L-type calcium channel beta subunit
• L27 domain, C-terminal
• Guanylate kinase, conserved site
• P-loop containing nucleoside triphosphate hydrolase
• SH3-like domain superfamily
• PDZ superfamily
• L27 domain superfamily
• Membrane-associated guanylate kinase
• PDZ domain
• Guanylate kinase
• L27 domain
• MPP4, SH3 domain

KeywordsUniProt

• Coiled coil
• Cytoplasm
• Repeat
• SH3 domain

InteractionsUniProt · HPA

Protein binding partners of MPP4 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• FASLG
• MPDZ
• CRB1