KATNAL2
Katanin p60 ATPase-containing subunit A-like 2
Also known as: DKFZP667C165, KATL2_HUMAN, MGC33211
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q8IYT4
- Gene
- KATNAL2
- Ensembl
- ENSG00000167216
- Chromosome
- 18
- Canonical length
- 538 aa
- Protein class
- Enzymes, Predicted intracellular proteins
- Subcellular location
- Nucleoplasm,Intermediate filaments
OverviewNCBI Gene
Predicted to enable ATP hydrolysis activity. Predicted to be involved in cytoplasmic microtubule organization. Located in cytoplasm; microtubule; and spindle pole. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
538 residues, UniProt reviewed canonical sequence.
>Q8IYT4|KATNAL2
1 MELSYQTLKF THQAREACEM RTEARRKNLL ILISHYLTQE GYIDTANALE QETKLGLRRF
61 EVCDNIDLET ILMEYESYYF VKFQKYPKIV KKSSDTAENN LPQRSRGKTR RMMNDSCQNL
121 PKINQQRPRS KTTAGKTGDT KSLNKEHPNQ EVVDNTRLES ANFGLHISRI RKDSGEENAH
181 PRRGQIIDFQ GLLTDAIKGA TSELALNTFD HNPDPSERLL KPLSAFIGMN SEMRELAAVV
241 SRDIYLHNPN IKWNDIIGLD AAKQLVKEAV VYPIRYPQLF TGILSPWKGL LLYGPPGTGK
301 TLLAKAVATE CKTTFFNISA STIVSKWRGD SEKLVRVLFE LARYHAPSTI FLDELESVMS
361 QRGTASGGEH EGSLRMKTEL LVQMDGLARS EDLVFVLAAS NLPWELDCAM LRRLEKRILV
421 DLPSREARQA MIYHWLPPVS KSRALELHTE LEYSVLSQET EGYSGSDIKL VCREAAMRPV
481 RKIFDALENH QSESSDLPRI QLDIVTTADF LDVLTHTKPS AKNLAQRYSD WQREFESVLocalizationUniProt · AlphaFold · HPA
Whether an antibody against KATNAL2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Intracellular
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.41
- Highest tissue expression
- 12 nTPM
Expression across tissuesHPA
Tissue
- testis: 12 nTPM
- choroid plexus: 12 nTPM
- parathyroid gland: 8.7 nTPM
- thyroid gland: 5.7 nTPM
- fallopian tube: 5.1 nTPM
- retina: 4.6 nTPM
Single-cell type
- choroid plexus epithelial cells: 299 nCPM
- ependymal cells: 255 nCPM
- late primary spermatocytes: 164 nCPM
- renal connecting tubule cells: 133 nCPM
- astrocytes: 129 nCPM
- respiratory ciliated cells: 127 nCPM
Immune cell
- naive B-cell: 0.2 nTPM
- intermediate monocyte: 0.1 nTPM
- MAIT T-cell: 0.1 nTPM
- memory B-cell: 0.1 nTPM
- memory CD8 T-cell: 0.1 nTPM
- naive CD4 T-cell: 0.1 nTPM
Brain region
- choroid plexus: 25 nTPM
- midbrain: 15 nTPM
- medulla oblongata: 14 nTPM
- basal ganglia: 14 nTPM
- pons: 14 nTPM
- thalamus: 13 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 0.82
- gnomAD pLI
- 0
- gnomAD missense Z
- 0.42
- DepMap mean gene effect
- 0.04
- DepMap dependency class
- none
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
Molecular functions
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads KATNAL2 as an antibody target. Whether an autoantibody or antibody against KATNAL2 could matter depends on whether native KATNAL2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
KATNAL2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label KATNAL2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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