DMC1

Protein identityUniProt · HPA

UniProt accession

Q14565

Gene

DMC1

Ensembl

ENSG00000100206

Chromosome

22

Canonical length

340 aa

Protein class

Predicted intracellular proteins

Subcellular location

Nucleoplasm

Quaternary structure

Homooctamer

OverviewNCBI Gene

This gene encodes a member of the superfamily of recombinases (also called DNA strand-exchange proteins). Recombinases are important for repairing double-strand DNA breaks during mitosis and meiosis. This protein, which is evolutionarily conserved, is reported to be essential for meiotic homologous recombination and may thus play an important role in generating diversity of genetic information. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2013]

Canonical amino-acid sequenceUniProt

340 residues, UniProt reviewed canonical sequence.

>Q14565|DMC1
     1  MKEDQVVAEE PGFQDEEESL FQDIDLLQKH GINVADIKKL KSVGICTIKG IQMTTRRALC
    61  NVKGLSEAKV DKIKEAANKL IEPGFLTAFE YSEKRKMVFH ITTGSQEFDK LLGGGIESMA
   121  ITEAFGEFRT GKTQLSHTLC VTAQLPGAGG YPGGKIIFID TENTFRPDRL RDIADRFNVD
   181  HDAVLDNVLY ARAYTSEHQM ELLDYVAAKF HEEAGIFKLL IIDSIMALFR VDFSGRGELA
   241  ERQQKLAQML SRLQKISEEY NVAVFVTNQM TADPGATMTF QADPKKPIGG HILAHASTTR
   301  ISLRKGRGEL RIAKIYDSPE MPENEATFAI TAGGIGDAKE

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against DMC1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.29

Highest tissue expression

11 nTPM

Expression across tissuesHPA

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about DMC1.

Disease | GeneticClinVar

5 pathogenic / likely-pathogenic of 44 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

• Non-obstructive azoospermia
• Azoospermia

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.77

gnomAD pLI

0

gnomAD missense Z

1.27

DepMap mean gene effect

0.01

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• chromosome organization involved in meiotic cell cycle
• DNA recombinase assembly
• DNA strand invasion
• double-strand break repair involved in meiotic recombination
• female gamete generation
• homologous chromosome pairing at meiosis
• male meiosis I
• meiotic cell cycle
• mitotic recombination
• oocyte maturation
• ovarian follicle development
• reciprocal meiotic recombination
• spermatid development
• spermatogenesis

Molecular functions

• ATP binding
• ATP-dependent activity, acting on DNA
• ATP-dependent DNA damage sensor activity
• DNA binding
• DNA strand exchange activity
• double-stranded DNA binding
• identical protein binding
• single-stranded DNA binding

Cellular components

• chromosome
• chromosome, telomeric region
• condensed nuclear chromosome
• lateral element
• nucleoplasm
• nucleus
• site of double-strand break

Protein domainsUniProt · Pfam · InterPro

• AAA+ ATPase domain
• DNA repair Rad51/transcription factor NusA, alpha-helical
• Rad51-like, C-terminal
• DNA recombination and repair protein, RecA-like
• DNA recombination and repair protein RecA, monomer-monomer interface
• DNA recombination and repair protein RecA-like, ATP-binding domain
• P-loop containing nucleoside triphosphate hydrolase
• Rad51
• Helix-hairpin-helix domain
• Meiotic recombination protein Dmc1

KeywordsUniProt

• ATP-binding
• Cell cycle
• Chromosome
• DNA-binding
• Meiosis
• Nucleotide-binding
• Nucleus

InteractionsUniProt · HPA

Protein binding partners of DMC1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• BRCA2
• RAD51AP1
• MND1