Seroatlas · Human Serome Atlas

ARF1

ADP-ribosylation factor 1

Also known as: ARF1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P84077
Gene
ARF1
Ensembl
ENSG00000143761
Chromosome
1
Canonical length
181 aa
Protein class
Disease related genes, Enzymes, Human disease related genes, Potential drug targets, Predicted intracellular proteins
Subcellular location
Plasma membrane,Cytosol

OverviewNCBI Gene

ADP-ribosylation factor 1 (ARF1) is a member of the human ARF gene family. The family members encode small guanine nucleotide-binding proteins that stimulate the ADP-ribosyltransferase activity of cholera toxin and play a role in vesicular trafficking as activators of phospholipase D. The gene products, including 6 ARF proteins and 11 ARF-like proteins, constitute a family of the RAS superfamily. The ARF proteins are categorized as class I (ARF1, ARF2 and ARF3), class II (ARF4 and ARF5) and class III (ARF6), and members of each class share a common gene organization. The ARF1 protein is localized to the Golgi apparatus and has a central role in intra-Golgi transport. Multiple alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

181 residues, UniProt reviewed canonical sequence.

>P84077|ARF1
     1  MGNIFANLFK GLFGKKEMRI LMVGLDAAGK TTILYKLKLG EIVTTIPTIG FNVETVEYKN
    61  ISFTVWDVGG QDKIRPLWRH YFQNTQGLIF VVDSNDRERV NEAREELMRM LAEDELRDAV
   121  LLVFANKQDL PNAMNAAEIT DKLGLHSLRH RNWYIQATCA TSGDGLYEGL DWLSNQLRNQ
   181  K

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ARF1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Other membrane
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.28
Highest tissue expression
468 nTPM

Expression across tissuesHPA

Tissue

  • bone marrow: 468 nTPM
  • salivary gland: 354 nTPM
  • heart muscle: 350 nTPM
  • blood vessel: 346 nTPM
  • skeletal muscle: 329 nTPM
  • pancreas: 321 nTPM

Single-cell type

  • platelets: 1,413 nCPM
  • esophageal apical cells: 1,289 nCPM
  • syncytiotrophoblasts: 898 nCPM
  • extravillous trophoblasts: 762 nCPM
  • late spermatids: 682 nCPM
  • esophageal suprabasal cells: 588 nCPM

Immune cell

  • total PBMC: 1,393 nTPM
  • basophil: 1,170 nTPM
  • neutrophil: 984 nTPM
  • eosinophil: 762 nTPM
  • classical monocyte: 699 nTPM
  • plasmacytoid DC: 666 nTPM

Brain region

  • hippocampal formation: 332 nTPM
  • cerebral cortex: 315 nTPM
  • hypothalamus: 304 nTPM
  • basal ganglia: 285 nTPM
  • choroid plexus: 285 nTPM
  • thalamus: 266 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about ARF1.

Disease | AllUniProt

Conditions ARF1 is implicated in, by any mechanism.

  • Periventricular nodular heterotopia 8 (PVNH8) MIM:618185

Disease | GeneticClinVar

12 pathogenic / likely-pathogenic of 41 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.4
gnomAD pLI
0.9
gnomAD missense Z
3.39
DepMap mean gene effect
-0.36
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 13% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ARF1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ARF1 as an antibody target. Whether an autoantibody or antibody against ARF1 could matter depends on whether native ARF1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ARF1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ARF1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/ARF1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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