Seroatlas · Human Serome Atlas

CHD9

Chromodomain-helicase-DNA-binding protein 9

Also known as: BC022889, CHD9_HUMAN, FLJ12178, KIAA0308

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q3L8U1
Gene: CHD9
Ensembl: ENSG00000177200
Chromosome: 16
Canonical length: 2897 aa
Protein class: Enzymes, Plasma proteins, Predicted intracellular proteins
Subcellular location: Nucleoplasm,Cytosol

OverviewNCBI Gene

Predicted to enable several functions, including ATP binding activity; ATP hydrolysis activity; and DNA helicase activity. Predicted to be involved in chromatin organization. Located in cytosol and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2025]

Canonical amino-acid sequenceUniProt

2897 residues, UniProt reviewed canonical sequence.

>Q3L8U1|CHD9
     1  MTDPMMDFFD DANLFGETLE GLSDDAFVQP GPVSLVDELN LGAEFEPLHI DSLNHVQGTP
    61  THQKMTDFEQ LNQFDSIKFH HVNQSFGSPA EHVLSPHSQF NCSPIHPQNQ PNGLFPDVSD
   121  GSPMWGHQTA TTISNQNGSP FHQQGHSHSM HQNKSFVAHH DFALFQANEQ QTQCTSLRSQ
   181  QNRNNLNPGQ NSLSQSKNFM NVSGPHRVNV NHPPQMTNAS NSQQSISMQQ FSQTSNPSAH
   241  FHKCSSHQEG NFNGPSPNMT SCSVSNSQQF SSHYSFSSNH ISPNSLLQSS AVLASNHTNQ
   301  TLSDFTGSNS FSPHRGIKQE STQHILNPNT SLNSNNFQIL HSSHPQGNYS NSKLSPVHMN
   361  FPDPVDSGTQ MGHFNDHVET NGFSSLEENL LHQVESQTEP FTGLDPEDLL QEGLLPHFDE
   421  STFGQDNSSH ILDHDLDRQF TSHLVTRPSD MAQTQLQSQA RSWHSSFSNH QHLHDRNHLC
   481  LQRQPPSSKK SDGSGTYTKL QNTQVRVMSE KKQRKKVESE SKQEKANRII SEAIAKAKER
   541  GERNIPRVMS PENFPTASVE GKEEKKGRRM KSKPKDKDSK KTKTCSKLKE KTKIGKLIIT
   601  LGKKQKRKNE SSDEISDAEQ MPQHTLKDQD SQKRRSNRQI KRKKYAEDIE GKQSEEEVKG
   661  SMKIKKNSAP LPGEQPLQLF VENPSEEDAA IVDKILSSRT VKKEISPGVM IDTEEFFVKY
   721  KNYSYLHCEW ATEEQLLKDK RIQQKIKRFK LRQAQRAHFF ADMEEEPFNP DYVEVDRVLE
   781  VSFCEDKDTG EPVIYYLVKW CSLPYEDSTW ELKEDVDLAK IEEFEQLQAS RPDTRRLDRP
   841  PSNIWKKIDQ SRDYKNGNQL REYQLEGLNW LLFNWYNRRN CILADEMGLG KTIQSITFLY
   901  EILLTGIRGP FLIIAPLSTI ANWEREFRTW TDINVVVYHG SLISRQMIQQ YEMYFRDSQG
   961  RIIRGAYRFQ AIITTFEMIL GGCGELNAIE WRCVIIDEAH RLKNKNCKLL EGLKLMNLEH
  1021  KVLLTGTPLQ NTVEELFSLL HFLEPLRFPS ESTFMQEFGD LKTEEQVQKL QAILKPMMLR
  1081  RLKEDVEKKL APKEETIIEV ELTNIQKKYY RAILEKNFSF LSKGAGQTNV PNLVNTMMEL
  1141  RKCCNHPYLI KGAEEKILGE FRDTYNPAAS DFHLQAMIQS AGKLVLIDKL LPKMKAGGHK
  1201  VLIFSQMVRC LDILEDYLIH KRYLYERIDG RVRGNLRQAA IDRFSKPDSD RFVFLLCTRA
  1261  GGLGINLTAA DTCIIFDSDW NPQNDLQAQA RCHRIGQNKA VKVYRLVTRN SYEREMFDRA
  1321  SLKLGLDKAV LQSMSGRESN VGGIQQLSKK EIEDLLRRGA YGAIMEEEDE GSKFCEEDID
  1381  QILLRRTKTI TIESEGRGST FAKASFVASG NRTDISLDDP NFWQKWAKKA EIDIEAISGR
  1441  NSLVIDTPRI RKQTRPFSAT KDELAELSEA ESEGDEKPKL RRPCDRSNGY GRTECFRVEK
  1501  NLLVYGWGRW REILSHGRFK RQLNEHDVEI ICRALLAYCL VHYRGDEKIK GFIWDLITPT
  1561  EDGQTRELQN HLGLSAPVPR GRKGKKVKTQ TSSFDIQKAE WLRKYNPEQL LQDEGYKKHI
  1621  KHHCNKVLLR VRMLYYLKQE VIGNECQKVF DGVDASDIDV WVPEPDHSEV PAEWWDFDAD
  1681  KSLLIGVFKH GYEKYNTIRA DPALCFLERV GKPDEKAVAA EQRANDYMDG DVEDPEYKPA
  1741  PAIFKDDIED DVSSPGDLVI ADGDGQLMEG DKVYWPTQSA LTTRLRRLIT AYQRTNKNRQ
  1801  IQQIQPTFSV PTSVMQPIYE EATLNPKMAA KIERQQRWTR REEADFYRVV STFGVVFDPD
  1861  RGQFDWTKFR AMARLHKKTD DSLEKYLYAF MSMCRRVCRL PSKEELVDPN IFIQPITEER
  1921  ASRTLYRIEL LRKVREQALR HPQLFERLKL CHPNPDLPVW WECGPHDRDL LIGAAKHGVS
  1981  RTDYHILRDP ELSFMAAQRN YSQSKMAHSR TSTPLLQQYQ VALSASPLTS LPRLLDAKGI
  2041  ILEEMKVKSE NLKEEPQSSE EESMSSVETR TLIKSEPVSP KNGVLPQATG DQKSGGKCET
  2101  DRRMVAARTE PLTPNPASKK PRVHKRGSES SSDSDSDSER SSCSSRSSSS SSSSSCSHSR
  2161  SGSSSSSSSS CSSASSSSSS STSSSSSSSS SSSEESDSDE EEAQKRESTT HMKAYDEESV
  2221  ASLSTTQDET QDSFQMNNGT PESAYILQGG YMLAASYWPK DRVMINRLDS ICQTVLKGKW
  2281  PSARRSYDAN TVASFYTTKL LDSPGAATEY SDPSVPTPPG AGVKEEHDQS TQMSKVKKHV
  2341  REKEFTVKIK DEGGLKLTFQ KQGLAQKRPF DGEDGALGQQ QYLTRLRELQ SASETSLVNF
  2401  PKSIPVSGTS IQPTLGANGV ILDNQPIVKK RRGRRKNVEG VDIFFFNRNK PPNHVSLGLT
  2461  SSQISTGINP ALSYTQPQGI PDTESPVPVI NLKDGTRLAG DDAPKRKDLE KWLKEHPGYV
  2521  EDLGAFIPRM QLHEGRPKQK RHRCRNPNKL DVNSLTGEER VQLINRRNAR KVGGAFAPPL
  2581  KDLCRFLKEN SEYGVAPEWG DVVKQSGFLP ESMYERILTG PVVREEVSRR GRRPKSGIAK
  2641  ATAAAAAASA TSVSGNPLLA NGLLPGVDLT TLQALQQNLQ NLQSLQVTAG LMGMPTGLPS
  2701  GGEAKNMAAM FPMLLSGMAG LPNLLGMGGL LTKPTESGTE DKKGSDSKES EGKTERTESQ
  2761  SSENGGENSV SSSPSTSSTA ALNTAAAANP LALNPLLLSN ILYPGMLLTP GLNLHIPTLS
  2821  QSNTFDVQNK NSDLGSSKSV EVKEEDSRIK DQEDKGGTEP SPLNENSTDE GSEKADASSG
  2881  SDSTSSSSED SDSSNED

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CHD9 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0
Highest tissue expression: 27 nTPM

Expression across tissuesHPA

Tissue

retina: 27 nTPM
bone marrow: 21 nTPM
tongue: 12 nTPM
thyroid gland: 12 nTPM
breast: 11 nTPM
kidney: 10 nTPM

Single-cell type

fibro-adipogenic progenitors: 1,054 nCPM
rod photoreceptor cells: 825 nCPM
microglia: 788 nCPM
adipocytes: 746 nCPM
myonuclei: 698 nCPM
oligodendrocyte progenitor cells: 655 nCPM

Immune cell

plasmacytoid DC: 127 nTPM
basophil: 102 nTPM
naive B-cell: 47 nTPM
non-classical monocyte: 40 nTPM
memory B-cell: 39 nTPM
NK-cell: 38 nTPM

Brain region

cerebellum: 142 nTPM
midbrain: 117 nTPM
basal ganglia: 116 nTPM
white matter: 114 nTPM
hypothalamus: 112 nTPM
pons: 112 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.17
gnomAD pLI: 1
gnomAD missense Z: 3.77
DepMap mean gene effect: 0
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

chromatin organization

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CHD9 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CHD9 as an antibody target. Whether an autoantibody or antibody against CHD9 could matter depends on whether native CHD9 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CHD9 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CHD9 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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