Seroatlas · Human Serome Atlas

NKIRAS1

NF-kappa-B inhibitor-interacting Ras-like protein 1

Also known as: kappaB-Ras1, KBRAS1, KBRS1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9NYS0
Gene: NKIRAS1
Ensembl: ENSG00000197885
Chromosome: 3
Canonical length: 192 aa
Protein class: Predicted intracellular proteins
Subcellular location: Endoplasmic reticulum,Cytosol

OverviewNCBI Gene

Predicted to enable GTPase activating protein binding activity. Predicted to be involved in Ral protein signal transduction. Predicted to act upstream of or within lung alveolus development; regulation of tumor necrosis factor-mediated signaling pathway; and surfactant homeostasis. Located in cytosol and endoplasmic reticulum. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

192 residues, UniProt reviewed canonical sequence.

>Q9NYS0|NKIRAS1
     1  MGKGCKVVVC GLLSVGKTAI LEQLLYGNHT IGMEDCETME DVYMASVETD RGVKEQLHLY
    61  DTRGLQEGVE LPKHYFSFAD GFVLVYSVNN LESFQRVELL KKEIDKFKDK KEVAIVVLGN
   121  KIDLSEQRQV DAEVAQQWAK SEKVRLWEVT VTDRKTLIEP FTLLASKLSQ PQSKSSFPLP
   181  GRKNKGNSNS EN

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against NKIRAS1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.33
Highest tissue expression: 47 nTPM

Expression across tissuesHPA

Tissue

cerebral cortex: 47 nTPM
retina: 44 nTPM
hypothalamus: 37 nTPM
parathyroid gland: 36 nTPM
cerebellum: 32 nTPM
skeletal muscle: 31 nTPM

Single-cell type

epicardial cells: 205 nCPM
oocytes: 157 nCPM
cardiomyocytes: 116 nCPM
rod photoreceptor cells: 103 nCPM
endometrial glandular cells: 95 nCPM
cone photoreceptor cells: 85 nCPM

Immune cell

basophil: 14 nTPM
MAIT T-cell: 9.8 nTPM
naive CD4 T-cell: 9.7 nTPM
gdT-cell: 8.9 nTPM
memory CD8 T-cell: 8.5 nTPM
naive B-cell: 8.1 nTPM

Brain region

cerebral cortex: 44 nTPM
hypothalamus: 43 nTPM
cerebellum: 40 nTPM
pons: 40 nTPM
midbrain: 38 nTPM
basal ganglia: 38 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.36
gnomAD pLI: 0
gnomAD missense Z: 0.88
DepMap mean gene effect: 0.05
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of NKIRAS1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads NKIRAS1 as an antibody target. Whether an autoantibody or antibody against NKIRAS1 could matter depends on whether native NKIRAS1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

NKIRAS1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label NKIRAS1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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