Seroatlas · Human Serome Atlas

ARL2

ADP-ribosylation factor-like protein 2

Also known as: ARFL2, ARL2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P36404
Gene
ARL2
Ensembl
ENSG00000213465
Chromosome
11
Canonical length
184 aa
Protein class
Disease related genes, Predicted intracellular proteins
Subcellular location
Nucleoplasm,Nucleoli,Mitochondria,Basal body,Equatorial segment,Flagellar centriole,Mid piece

OverviewNCBI Gene

This gene encodes a small GTP-binding protein of the RAS superfamily which functions as an ADP-ribosylation factor (ARF). The encoded protein is one of a functionally distinct group of ARF-like genes. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

184 residues, UniProt reviewed canonical sequence.

>P36404|ARL2
     1  MGLLTILKKM KQKERELRLL MLGLDNAGKT TILKKFNGED IDTISPTLGF NIKTLEHRGF
    61  KLNIWDVGGQ KSLRSYWRNY FESTDGLIWV VDSADRQRMQ DCQRELQSLL VEERLAGATL
   121  LIFANKQDLP GALSSNAIRE VLELDSIRSH HWCIQGCSAV TGENLLPGID WLLDDISSRI
   181  FTAD

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ARL2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Other membrane
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.27
Highest tissue expression
286 nTPM

Expression across tissuesHPA

Tissue

  • basal ganglia: 286 nTPM
  • spinal cord: 234 nTPM
  • skeletal muscle: 216 nTPM
  • midbrain: 173 nTPM
  • amygdala: 172 nTPM
  • heart muscle: 169 nTPM

Single-cell type

  • late spermatids: 291 nCPM
  • early spermatids: 77 nCPM
  • oligodendrocytes: 42 nCPM
  • melanocytes: 34 nCPM
  • late primary spermatocytes: 30 nCPM
  • other brain neurons: 29 nCPM

Immune cell

  • memory B-cell: 164 nTPM
  • naive B-cell: 150 nTPM
  • plasmacytoid DC: 141 nTPM
  • naive CD8 T-cell: 138 nTPM
  • total PBMC: 137 nTPM
  • MAIT T-cell: 131 nTPM

Brain region

  • basal ganglia: 183 nTPM
  • white matter: 168 nTPM
  • spinal cord: 148 nTPM
  • cerebellum: 148 nTPM
  • medulla oblongata: 146 nTPM
  • hypothalamus: 140 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about ARL2.

Disease | AllUniProt

Conditions ARL2 is implicated in, by any mechanism.

  • Microcornea, rod-cone dystrophy, cataract, and posterior staphyloma 1 (MRCS1) MIM:619082

Disease | GeneticClinVar

1 pathogenic / likely-pathogenic of 28 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

  • Microcornea, rod-cone dystrophy, cataract, and posterior staphyloma 1

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1
gnomAD pLI
0.02
gnomAD missense Z
1.05
DepMap mean gene effect
-1.62
DepMap dependency class
pan

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ARL2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ARL2 as an antibody target. Whether an autoantibody or antibody against ARL2 could matter depends on whether native ARL2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ARL2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ARL2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/ARL2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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