Seroatlas · Human Serome Atlas

SEPTIN7

Septin-7

Also known as: CDC10, CDC3, SEPT7, SEPT7_HUMAN, SEPT7A

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q16181
Gene
SEPTIN7
Ensembl
ENSG00000122545
Chromosome
7
Canonical length
437 aa
Protein class
Plasma proteins, Predicted intracellular proteins
Subcellular location
Actin filaments,Cytokinetic bridge,Midbody,Primary cilium
Quaternary structure
Homodimer

OverviewNCBI Gene

This gene encodes a protein that is highly similar to the CDC10 protein of Saccharomyces cerevisiae. The protein also shares similarity with Diff 6 of Drosophila and with H5 of mouse. Each of these similar proteins, including the yeast CDC10, contains a GTP-binding motif. The yeast CDC10 protein is a structural component of the 10 nm filament which lies inside the cytoplasmic membrane and is essential for cytokinesis. This human protein functions in gliomagenesis and in the suppression of glioma cell growth, and it is required for the association of centromere-associated protein E with the kinetochore. Alternative splicing results in multiple transcript variants. Several related pseudogenes have been identified on chromosomes 5, 7, 9, 10, 11, 14, 17 and 19. [provided by RefSeq, Jul 2011]

Canonical amino-acid sequenceUniProt

437 residues, UniProt reviewed canonical sequence.

>Q16181|SEPTIN7
     1  MSVSARSAAA EERSVNSSTM VAQQKNLEGY VGFANLPNQV YRKSVKRGFE FTLMVVGESG
    61  LGKSTLINSL FLTDLYSPEY PGPSHRIKKT VQVEQSKVLI KEGGVQLLLT IVDTPGFGDA
   121  VDNSNCWQPV IDYIDSKFED YLNAESRVNR RQMPDNRVQC CLYFIAPSGH GLKPLDIEFM
   181  KRLHEKVNII PLIAKADTLT PEECQQFKKQ IMKEIQEHKI KIYEFPETDD EEENKLVKKI
   241  KDRLPLAVVG SNTIIEVNGK RVRGRQYPWG VAEVENGEHC DFTILRNMLI RTHMQDLKDV
   301  TNNVHYENYR SRKLAAVTYN GVDNNKNKGQ LTKSPLAQME EERREHVAKM KKMEMEMEQV
   361  FEMKVKEKVQ KLKDSEAELQ RRHEQMKKNL EAQHKELEEK RRQFEDEKAN WEAQQRILEQ
   421  QNSSRTLEKN KKKGKIF

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SEPTIN7 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.39
Highest tissue expression
227 nTPM

Expression across tissuesHPA

Tissue

  • cerebral cortex: 227 nTPM
  • amygdala: 170 nTPM
  • midbrain: 163 nTPM
  • spinal cord: 162 nTPM
  • hippocampal formation: 161 nTPM
  • ovary: 160 nTPM

Single-cell type

  • oligodendrocytes: 2,033 nCPM
  • retinal horizontal cells: 1,114 nCPM
  • megakaryocytes: 878 nCPM
  • esophageal apical cells: 757 nCPM
  • pericytes: 728 nCPM
  • vascular smooth muscle cells: 639 nCPM

Immune cell

  • NK-cell: 259 nTPM
  • basophil: 226 nTPM
  • total PBMC: 215 nTPM
  • MAIT T-cell: 196 nTPM
  • gdT-cell: 189 nTPM
  • memory CD8 T-cell: 177 nTPM

Brain region

  • white matter: 351 nTPM
  • basal ganglia: 295 nTPM
  • thalamus: 265 nTPM
  • cerebral cortex: 246 nTPM
  • midbrain: 234 nTPM
  • amygdala: 216 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.19
gnomAD pLI
1

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 9% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SEPTIN7 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SEPTIN7 as an antibody target. Whether an autoantibody or antibody against SEPTIN7 could matter depends on whether native SEPTIN7 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SEPTIN7 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SEPTIN7 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/SEPTIN7. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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