Seroatlas · Human Serome Atlas

DNAH11

Dynein axonemal heavy chain 11

Also known as: CILD7, DNAHBL, Dnahc11, DNHBL, DPL11, DYH11_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q96DT5
Gene: DNAH11
Ensembl: ENSG00000105877
Chromosome: 7
Canonical length: 4516 aa
Protein class: Disease related genes, Human disease related genes, Predicted intracellular proteins

OverviewNCBI Gene

This gene encodes a ciliary outer dynein arm protein and is a member of the dynein heavy chain family. It is a microtubule-dependent motor ATPase and has been reported to be involved in the movement of respiratory cilia. Mutations in this gene have been implicated in causing Kartagener Syndrome (a combination of situs inversus totalis and Primary Ciliary Dyskinesia (PCD), also called Immotile Cilia Syndrome 1 (ICS1)) and male sterility. [provided by RefSeq, Mar 2013]

Canonical amino-acid sequenceUniProt

4516 residues, UniProt reviewed canonical sequence.

>Q96DT5|DNAH11
     1  MAAQVAAREA RDFREAPTLR LTSGAGLEAV GAVELEEEEE NEEEAAARRA RSFAQDARVR
    61  FLGGRLAMML GFTEEKWSQY LESEDNRQVL GEFLESTSPA CLVFSFAASG RLAASQEIPR
   121  DANHKLVFIS KKITESIGVN DFSQVVLFGE LPALSLGHVS AFLDEILVPV LSNKNNHKSW
   181  SCFTSQDMEY HIEVMKKKMY IFRGKMSRRT LLPIPTVAGK MDLDQNCSEN KPPSNERIIL
   241  HAIESVVIEW SHQIQEIIER DSVQRLLNGL HLSPQAELDF WMMRRENLSC IYDQLQAPVV
   301  LKMVKILTTK QSSYFPTLKD IFLAVENALL EAQDVELYLR PLRRHIQCLQ ETEFPQTRIL
   361  IAPLFHTICL IWSHSKFYNT PARVIVLLQE FCNLFINQAT AYLSPEDLLR GEIEESLEKV
   421  QVAVNILKTF KNSFFNYRKK LASYFMGRKL RPWDFQSHLV FCRFDKFLDR LIKIEDIFAT
   481  TLEFEKLERL EFGGTKGAIL NGQVHEMSEE LMELCKLFKQ STYDPSDCTN MEFESDYVAF
   541  KSKTLEFDRR LGTIICEAFF NCNGLEAAFK LLTIFGNFLE KPVVMEIFSL HYSTLVHMFN
   601  TELDVCKQLY NEHMKQIECG HVVLNKNMPF TSGNMKWAQQ VLQRLQMFWS NFASLRYLFL
   661  GNPDHALVYQ KYVEMTTLLD QFESRIYNEW KSNVDEICEF NLNQPLVKFS AINGLLCVNF
   721  DPKLVAVLRE VKYLLMLKKQ DIPDSALAIF KKRNTILKYI GNLDLLVQGY NKLKQTLLEV
   781  EYPLIEDELR AIDEQLTAAT TWLTWQDDCW GYIERVRAAT SELEHRVERT QKNVKVIQQT
   841  MRGWARCVLP PRREHRREAA FTLEDKGDLF TKKYKLIQGD GCKIHNLVEE NRKLFKANPS
   901  LDTWKIYVEF IDDIVVEGFF QAIMHDLDFF LKNTEKQLKP APFFQAQMIL LPPEIVFKPS
   961  LDREAGDGFY DLVEEMLCNS FRMSAQMNRI ATHLEIKNYQ NDMDNMLGLA EVRQEIMNRV
  1021  VNVINKVLDF RNTLETHTYL WVDDRAEFMK HFLLYGHAVS SDEMDAHANE EIPEQPPTLE
  1081  QFKEQIDIYE ALYVQMSKFE DFRVFDSWFK VDMKPFKVSL LTIIKKWSWM FQEHLLRFVI
  1141  DSLNELQEFI KETDSGLQRE LNEGDHDGLV DIMVHLLAVR SRQRATDELF EPLKETITLL
  1201  ESYGQKMPEQ VYIQLEELPE RWETTKKIAA TVRHEVSPLH NAEVTLIRKK CILFDAKQAE
  1261  FRERFRHYAP LGFNAENPYT ALDKANEELE ALEEEMLQMQ ESTRLFEVAL PEYKQMKQCR
  1321  KEIKLLKGLW DVIIYVRRSI DNWTKTQWRQ IHVEQMDVEL RRFAKEIWSL NKEVRVWDAY
  1381  TGLEGTVKDM TASLRAITEL QSPALRDRHW HQLMKAIGVK FLINEATTLA DLLALRLHRV
  1441  EDDVRRIVDK AVKELGTEKV ITEISQTWAT MKFSYEVHYR TGIPLLKSDE QLFETLEHNQ
  1501  VQLQTLLQSK YVEYFIEQVL SWQNKLNIAD LVIFTWMEVQ RTWSHLESIF VCSEDIRIQL
  1561  VKDARRFDGV DAEFKELMFK TAKVENVLEA TCRPNLYEKL KDLQSRLSLC EKALAEYLET
  1621  KRIAFPRFYF VSSADLLDIL SKGAQPKQVT CHLAKLFDSI ADLQFEDNQD VSAHRAVGMY
  1681  SKEKEYVPFQ AECECVGHVE TWLLQLEQTM QETVRHSITE AIVAYEEKPR ELWIFDFPAQ
  1741  VALTSSQIWW TTDVGIAFSR LEEGYETALK DFHKKQISQL NTLITLLLGE LPPGDRQKIM
  1801  TICTIDVHAR DVVAKLISQK VVSPQAFTWL SQLRHRWEDT QKHCFVNICD AQFQYFYEYL
  1861  GNSPRLVITP LTDRCYITLT QSLHLTMSGA PAGPAGTGKT ETTKDLGRAL GMMVYVFNCS
  1921  EQMDYKSIGN IYKGLVQTGA WGCFDEFNRI SVEVLSVVAV QVKMIHDAIR NRKKRFVFLG
  1981  EAITLKPSVG IFITMNPGYA GRTELPENLK ALFRPCAMVA PDIELICEIL LVAEGFVDAR
  2041  ALARKFITLY TLCKELLSKQ DHYDWGLRAI KSVLVVAGSL KRGDKNRPED QVLMRALRDF
  2101  NMPKIVTDDI PVFLGLVGDL FPALDVPRRR KLHFEQMVRQ STLELRLQPE ESFILKVVQL
  2161  EELLAVRHSV FVVGNAGTGK SKILRTLNRT YVNMKQKPVW NDLNPKAVTT DELFGFIHHA
  2221  TREWKDGKIV YSYFIGLFSS ILREQANLKH DGPKWIVLDG DIDPMWIESL NTVMDDNKVL
  2281  TLASNERIAL TPFMRLLFEI HHLRSATPAT VSRAGILYVN PQDLGWNPYV ASWIDRRRHQ
  2341  SEKANLTILF DKYVPACLDK LRTSFKTITS IPESSLVQTL CVLLECLLTP ENVPSDSPKE
  2401  VYEVYFVFAC IWAFGGTLLQ DQISDYQADF SRWWQKEMKA VKFPSQGTIF DYYVDHKTKK
  2461  LLPWADKIAQ FTMDPDVPLQ TVLVHTTETA RLRYFMELLL EKGKPLMLVG NAGVGKTVFV
  2521  GDTLASLSED YIVSRVPFNY YTTSTALQKI LEKPLEKKAG HNYGPGGNKK LIYFIDDMNM
  2581  PEVDLYGTVQ PHTLIRQHID YGHWYDRQKV MLKEIHNCQY VACMNPMVGS FTINPRLQRH
  2641  FTVFAFNFPS LDALNTIYGQ IFSFHFQQQA FAPSILRSGP TLIQATIAFH QTMMCNFLPT
  2701  AIKFHYIFNL RDLSNVFQGI LFASPECLKG PLDLIHLWLH ESARVYGDKL IDKKDCDLFQ
  2761  RRMLETAYKY FEGIDSHMLL QQPLIYCHFA DRGKDPHYMP VKDWEVLKTI LTETLDNYNE
  2821  LNAAMHLVLF EDAMQHVCRI SRILRTPQGC ALLVGVGGSG KQSLSRLAAY LRGLEVFQIT
  2881  LTEGYGIQEL RVDLANLYIR TGAKNMPTVF LLTDAQVLDE SFLVLINDLL ASGEIPDLFS
  2941  DEDVDKIISG IHNEVHALGM VDSRENCWKF FMARVRLQLK IILCFSPVGR TLRVRARKFP
  3001  AIVNCTAIDW FHAWPQEALV SVSRRFIEET KGIEPVHKDS ISLFMAHVHT TVNEMSTRYY
  3061  QNERRHNYTT PKSFLEQISL FKNLLKKKQN EVSEKKERLV NGIQKLKTTA SQVGDLKARL
  3121  ASQEAELQLR NHDAEALITK IGLQTEKVSR EKTIADAEER KVTAIQTEVF QKQRECEADL
  3181  LKAEPALVAA TAALNTLNRV NLSELKAFPN PPIAVTNVTA AVMVLLAPRG RVPKDRSWKA
  3241  AKVFMGKVDD FLQALINYDK EHIPENCLKV VNEHYLKDPE FNPNLIRTKS FAAAGLCAWV
  3301  INIIKFYEVY CDVEPKRQAL AQANLELAAA TEKLEAIRKK LVDLDRNLSR LTASFEKATA
  3361  EKVRCQEEVN QTNKTIKLAN RLVKELEAKK IRWGQSIKSF EAQEKTLCGD VLLTAAFVSY
  3421  VGPFTRQYRQ ELVHCKWVPF LQQKVSIPLT EGLDLISMLT DDATIAAWNN EGLPSDRMST
  3481  ENAAILTHCE RWPLVIDPQQ QGIKWIKNKY GMDLKVTHLG QKGFLNAIET ALAFGDVILI
  3541  ENLEETIDPV LDPLLGRNTI KKGKYIRIGD KECEFNKNFR LILHTKLANP HYKPELQAQT
  3601  TLLNFTVTED GLEAQLLAEV VSIERPDLEK LKLVLTKHQN DFKIELKYLE DDLLLRLSAA
  3661  EGSFLDDTKL VERLEATKTT VAEIEHKVIE AKENERKINE ARECYRPVAA RASLLYFVIN
  3721  DLQKINPLYQ FSLKAFNVLF HRAIEQADKV EDMQGRISIL MESITHAVFL YTSQALFEKD
  3781  KLTFLSQMAF QILLRKKEID PLELDFLLRF TVEHTHLSPV DFLTSQSWSA IKAIAVMEEF
  3841  RGIDRDVEGS AKQWRKWVES ECPEKEKLPQ EWKKKSLIQK LILLRAMRPD RMTYALRNFV
  3901  EEKLGAKYVE RTRLDLVKAF EESSPATPIF FILSPGVDAL KDLEILGKRL GFTIDSGKFH
  3961  NVSLGQGQET VAEVALEKAS KGGHWVILQN VHLVAKWLGT LEKLLERFSQ GSHRDYRVFM
  4021  SAESAPTPDE HIIPQGLLEN SIKITNEPPT GMLANLHAAL YNFDQDTLEI CSKEQEFKSI
  4081  LFSLCYFHAC VAGRLRFGPQ GWSRSYPFNP GDLTICASVL YNYLEANSKV PWEDLRYLFG
  4141  EIMYGGHITD DWDRKLCRVY LEEFMNPSLT EDELMLAPGF AAPPYLDYAG YHQYIEEMLP
  4201  PESPALYGLH PNAEIEFLTV TSNTLFRTLL EMQPRNALSG DELGQSTEEK VKNVLDDILE
  4261  KLPEEFNMAE IMQKNSNRSP YVLVCFQECE RMNILIREIR ISLEQLDLSL KGELALSPAV
  4321  EAQQFALSYD TVPDTWSKLA YPSTYGLAQW FNDLLLRCRE LDTWTQDLTL PAVVWLSGFF
  4381  NPQSFLTAIM QTMARKNEWP LDKTRLTADV TKKTKEDYGH PPREGAYLHG LFMEGARWDT
  4441  QAGTIVEARL KELACPMPVI FAKATPVDRQ ETKQTYECPV YRTKLRGPSY IWTFRLKSEE
  4501  KTAKWVLAGV ALLLEA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against DNAH11 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0
Highest tissue expression: 67 nTPM

Expression across tissuesHPA

Tissue

parathyroid gland: 67 nTPM
choroid plexus: 6.8 nTPM
fallopian tube: 4.9 nTPM
adrenal gland: 1.7 nTPM
lung: 1.1 nTPM
thyroid gland: 0.9 nTPM

Single-cell type

ependymal cells: 1,710 nCPM
respiratory ciliated cells: 1,700 nCPM
choroid plexus epithelial cells: 1,446 nCPM
endometrial ciliated cells: 1,106 nCPM
fallopian tube ciliated cells: 877 nCPM
epididymal efferent duct ciliated cells: 798 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

choroid plexus: 75 nTPM
medulla oblongata: 20 nTPM
spinal cord: 14 nTPM
midbrain: 12 nTPM
white matter: 6.4 nTPM
pons: 5.4 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about DNAH11.

Disease | AllUniProt

Conditions DNAH11 is implicated in, by any mechanism.

Ciliary dyskinesia, primary, 7 (CILD7) MIM:611884

Disease | GeneticClinVar

586 pathogenic / likely-pathogenic of 6,612 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Primary ciliary dyskinesia
Primary ciliary dyskinesia 7
DNAH11-related disorder
Respiratory ciliopathies including non-CF bronchiectasis
Laterality defects, autosomal dominant

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.67
gnomAD pLI: 0
gnomAD missense Z: -5.61
DepMap mean gene effect: 0.04
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of DNAH11 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

CFAP45

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads DNAH11 as an antibody target. Whether an autoantibody or antibody against DNAH11 could matter depends on whether native DNAH11 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

DNAH11 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label DNAH11 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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