Seroatlas · Human Serome Atlas

RAB4B

Ras-related protein Rab-4B

Also known as: FLJ78649, MGC52123, RAB4B_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P61018
Gene: RAB4B
Ensembl: ENSG00000167578
Chromosome: 19
Canonical length: 213 aa
Protein class: Enzymes, Predicted intracellular proteins

OverviewNCBI Gene

Enables GTPase activity. Involved in D-glucose import; early endosome to Golgi transport; and endosomal vesicle fusion. Located in insulin-responsive compartment; perinuclear region of cytoplasm; and recycling endosome. Is active in early endosome membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

213 residues, UniProt reviewed canonical sequence.

>P61018|RAB4B
     1  MAETYDFLFK FLVIGSAGTG KSCLLHQFIE NKFKQDSNHT IGVEFGSRVV NVGGKTVKLQ
    61  IWDTAGQERF RSVTRSYYRG AAGALLVYDI TSRETYNSLA AWLTDARTLA SPNIVVILCG
   121  NKKDLDPERE VTFLEASRFA QENELMFLET SALTGENVEE AFLKCARTIL NKIDSGELDP
   181  ERMGSGIQYG DASLRQLRQP RSAQAVAPQP CGC

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RAB4B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.29
Highest tissue expression: 109 nTPM

Expression across tissuesHPA

Tissue

spinal cord: 109 nTPM
midbrain: 84 nTPM
cerebral cortex: 78 nTPM
hippocampal formation: 76 nTPM
basal ganglia: 72 nTPM
amygdala: 70 nTPM

Single-cell type

oligodendrocytes: 58 nCPM
microglia: 37 nCPM
astrocytes: 33 nCPM
bergmann glia: 26 nCPM
ependymal cells: 24 nCPM
choroid plexus epithelial cells: 23 nCPM

Immune cell

plasmacytoid DC: 152 nTPM
eosinophil: 117 nTPM
neutrophil: 114 nTPM
naive B-cell: 90 nTPM
basophil: 87 nTPM
intermediate monocyte: 84 nTPM

Brain region

medulla oblongata: 92 nTPM
white matter: 91 nTPM
cerebellum: 83 nTPM
pons: 83 nTPM
thalamus: 78 nTPM
spinal cord: 73 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.51
gnomAD pLI: 0.67
gnomAD missense Z: 0.92
DepMap mean gene effect: -0.01
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RAB4B as an antibody target. Whether an autoantibody or antibody against RAB4B could matter depends on whether native RAB4B is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RAB4B is annotated at the cell surface, where native RAB4B is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label RAB4B as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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