Seroatlas · Human Serome Atlas

TEP1

Telomerase protein component 1

Also known as: p240, TEP1_HUMAN, TLP1, TP1, TROVE1, VAULT2

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q99973
Gene: TEP1
Ensembl: ENSG00000129566
Chromosome: 14
Canonical length: 2627 aa
Protein class: Plasma proteins, Predicted intracellular proteins
Subcellular location: Nucleoplasm,Vesicles

OverviewNCBI Gene

This gene product is a component of the ribonucleoprotein complex responsible for telomerase activity which catalyzes the addition of new telomeres on the chromosome ends. The telomerase-associated proteins are conserved from ciliates to humans. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016]

Canonical amino-acid sequenceUniProt

2627 residues, UniProt reviewed canonical sequence.

>Q99973|TEP1
     1  MEKLHGHVSA HPDILSLENR CLAMLPDLQP LEKLHQHVST HSDILSLKNQ CLATLPDLKT
    61  MEKPHGYVSA HPDILSLENQ CLATLSDLKT MEKPHGHVSA HPDILSLENR CLATLSSLKS
   121  TVSASPLFQS LQISHMTQAD LYRVNNSNCL LSEPPSWRAQ HFSKGLDLST CPIALKSISA
   181  TETAQEATLG RWFDSEEKKG AETQMPSYSL SLGEEEEVED LAVKLTSGDS ESHPEPTDHV
   241  LQEKKMALLS LLCSTLVSEV NMNNTSDPTL AAIFEICREL ALLEPEFILK ASLYARQQLN
   301  VRNVANNILA IAAFLPACRP HLRRYFCAIV QLPSDWIQVA ELYQSLAEGD KNKLVPLPAC
   361  LRTAMTDKFA QFDEYQLAKY NPRKHRAKRH PRRPPRSPGM EPPFSHRCFP RYIGFLREEQ
   421  RKFEKAGDTV SEKKNPPRFT LKKLVQRLHI HKPAQHVQAL LGYRYPSNLQ LFSRSRLPGP
   481  WDSSRAGKRM KLSRPETWER ELSLRGNKAS VWEELIENGK LPFMAMLRNL CNLLRVGISS
   541  RHHELILQRL QHAKSVIHSR QFPFRFLNAH DAIDALEAQL RNQALPFPSN ITLMRRILTR
   601  NEKNRPRRRF LCHLSRQQLR MAMRIPVLYE QLKREKLRVH KARQWKYDGE MLNRYRQALE
   661  TAVNLSVKHS LPLLPGRTVL VYLTDANADR LCPKSNPQGP PLNYALLLIG MMITRAEQVD
   721  VVLCGGDTLK TAVLKAEEGI LKTAIKLQAQ VQEFDENDGW SLNTFGKYLL SLAGQRVPVD
   781  RVILLGQSMD DGMINVAKQL YWQRVNSKCL FVGILLRRVQ YLSTDLNPND VTLSGCTDAI
   841  LKFIAEHGAS HLLEHVGQMD KIFKIPPPPG KTGVQSLRPL EEDTPSPLAP VSQQGWRSIR
   901  LFISSTFRDM HGERDLLLRS VLPALQARAA PHRISLHGID LRWGVTEEET RRNRQLEVCL
   961  GEVENAQLFV GILGSRYGYI PPSYNLPDHP HFHWAQQYPS GRSVTEMEVM QFLNRNQRLQ
  1021  PSAQALIYFR DSSFLSSVPD AWKSDFVSES EEAARRISEL KSYLSRQKGI TCRRYPCEWG
  1081  GVAAGRPYVG GLEEFGQLVL QDVWNMIQKL YLQPGALLEQ PVSIPDDDLV QATFQQLQKP
  1141  PSPARPRLLQ DTVQRLMLPH GRLSLVTGQS GQGKTAFLAS LVSALQAPDG AKVASLVFFH
  1201  FSGARPDQGL ALTLLRRLCT YLRGQLKEPG ALPSTYRSLV WELQQRLLPK SAESLHPGQT
  1261  QVLIIDGADR LVDQNGQLIS DWIPKKLPRC VHLVLSVSSD AGLGETLEQS QGAHVLALGP
  1321  LEASARARLV REELALYGKR LEESPFNNQM RLLLVKRESG RPLYLRLVTD HLRLFTLYEQ
  1381  VSERLRTLPA TVPLLLQHIL STLEKEHGPD VLPQALTALE VTRSGLTVDQ LHGVLSVWRT
  1441  LPKGTKSWEE AVAAGNSGDP YPMGPFACLV QSLRSLLGEG PLERPGARLC LPDGPLRTAA
  1501  KRCYGKRPGL EDTAHILIAA QLWKTCDADA SGTFRSCPPE ALGDLPYHLL QSGNRGLLSK
  1561  FLTNLHVVAA HLELGLVSRL LEAHALYASS VPKEEQKLPE ADVAVFRTFL RQQASILSQY
  1621  PRLLPQQAAN QPLDSPLCHQ ASLLSRRWHL QHTLRWLNKP RTMKNQQSSS LSLAVSSSPT
  1681  AVAFSTNGQR AAVGTANGTV YLLDLRTWQE EKSVVSGCDG ISACLFLSDD TLFLTAFDGL
  1741  LELWDLQHGC RVLQTKAHQY QITGCCLSPD CRLLATVCLG GCLKLWDTVR GQLAFQHTYP
  1801  KSLNCVAFHP EGQVIATGSW AGSISFFQVD GLKVTKDLGA PGASIRTLAF NVPGGVVAVG
  1861  RLDSMVELWA WREGARLAAF PAHHGFVAAA LFLHAGCQLL TAGEDGKVQV WSGSLGRPRG
  1921  HLGSLSLSPA LSVALSPDGD RVAVGYRADG IRIYKISSGS QGAQGQALDV AVSALAWLSP
  1981  KVLVSGAEDG SLQGWALKEC SLQSLWLLSR FQKPVLGLAT SQELLASASE DFTVQLWPRQ
  2041  LLTRPHKAED FPCGTELRGH EGPVSCCSFS TDGGSLATGG RDRSLLCWDV RTPKTPVLIH
  2101  SFPACHRDWV TGCAWTKDNL LISCSSDGSV GLWDPESGQR LGQFLGHQSA VSAVAAVEEH
  2161  VVSVSRDGTL KVWDHQGVEL TSIPAHSGPI SHCAAAMEPR AAGQPGSELL VVTVGLDGAT
  2221  RLWHPLLVCQ THTLLGHSGP VRAAAVSETS GLMLTASEDG SVRLWQVPKE ADDTCIPRSS
  2281  AAVTAVAWAP DGSMAVSGNQ AGELILWQEA KAVATAQAPG HIGALIWSSA HTFFVLSADE
  2341  KISEWQVKLR KGSAPGNLSL HLNRILQEDL GVLTSLDWAP DGHFLILAKA DLKLLCMKPG
  2401  DAPSEIWSSY TENPMILSTH KEYGIFVLQP KDPGVLSFLR QKESGEFEER LNFDINLENP
  2461  SRTLISITQA KPESESSFLC ASSDGILWNL AKCSPEGEWT TGNMWQKKAN TPETQTPGTD
  2521  PSTCRESDAS MDSDASMDSE PTPHLKTRQR RKIHSGSVTA LHVLPELLVT ASKDRDVKLW
  2581  ERPSMQLLGL FRCEGSVSCL EPWLGANSTL QLAVGDVQGN VYFLNWE

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TEP1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.29
Highest tissue expression: 26 nTPM

Expression across tissuesHPA

Tissue

duodenum: 26 nTPM
rectum: 17 nTPM
colon: 16 nTPM
small intestine: 15 nTPM
spleen: 14 nTPM
tonsil: 14 nTPM

Single-cell type

foveolar cells: 56 nCPM
microglia: 52 nCPM
myonuclei: 43 nCPM
enterocytes: 40 nCPM
adipocytes: 39 nCPM
thymic myoid cells: 38 nCPM

Immune cell

plasmacytoid DC: 5.4 nTPM
neutrophil: 4.6 nTPM
basophil: 3.7 nTPM
non-classical monocyte: 2.9 nTPM
intermediate monocyte: 2.8 nTPM
naive B-cell: 2.4 nTPM

Brain region

choroid plexus: 16 nTPM
medulla oblongata: 16 nTPM
thalamus: 16 nTPM
pons: 14 nTPM
white matter: 14 nTPM
cerebral cortex: 12 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.84
gnomAD pLI: 0
gnomAD missense Z: 0.08
DepMap mean gene effect: -0.07
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

telomere maintenance via recombination

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

WD40 repeat
NACHT nucleoside triphosphatase
TROVE domain
WD40/YVTN repeat-like-containing domain superfamily
P-loop containing nucleoside triphosphate hydrolase
WD40-repeat-containing domain superfamily
TROVE domain superfamily
WD domain, G-beta repeat
NACHT domain
TROVE domain
TEP1, N-terminal
Domain of unknown function DUF4062
Domain of unknown function DUF5920
Telomerase Complex Component
TEP-1, C-terminal beta-propeller
TEP-1, second beta-propeller
TEP1 N-terminal domain
Domain of unknown function (DUF4062)
Domain of unknown function (DUF5920)
TEP-1 second beta-propeller
TEP-1 C-terminal beta-propeller

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of TEP1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TEP1 as an antibody target. Whether an autoantibody or antibody against TEP1 could matter depends on whether native TEP1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TEP1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TEP1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...