SUPV3L1

Protein identityUniProt · HPA

UniProt accession

Q8IYB8

Gene

SUPV3L1

Ensembl

ENSG00000156502

Chromosome

10

Canonical length

786 aa

Protein class

Enzymes, Predicted intracellular proteins

Subcellular location

Mitochondria

Quaternary structure

Homodimer

OverviewNCBI Gene

Enables several functions, including double-stranded RNA binding activity; helicase activity; and protein homodimerization activity. Involved in several processes, including mitochondrial RNA 3'-end processing; mitochondrial RNA surveillance; and positive regulation of mitochondrial RNA catabolic process. Located in mitochondrial nucleoid and nucleus. Part of mitochondrial degradosome. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

786 residues, UniProt reviewed canonical sequence.

>Q8IYB8|SUPV3L1
     1  MSFSRALLWA RLPAGRQAGH RAAICSALRP HFGPFPGVLG QVSVLATASS SASGGSKIPN
    61  TSLFVPLTVK PQGPSADGDV GAELTRPLDK NEVKKVLDKF YKRKEIQKLG ADYGLDARLF
   121  HQAFISFRNY IMQSHSLDVD IHIVLNDICF GAAHADDLFP FFLRHAKQIF PVLDCKDDLR
   181  KISDLRIPPN WYPDARAMQR KIIFHSGPTN SGKTYHAIQK YFSAKSGVYC GPLKLLAHEI
   241  FEKSNAAGVP CDLVTGEERV TVQPNGKQAS HVSCTVEMCS VTTPYEVAVI DEIQMIRDPA
   301  RGWAWTRALL GLCAEEVHLC GEPAAIDLVM ELMYTTGEEV EVRDYKRLTP ISVLDHALES
   361  LDNLRPGDCI VCFSKNDIYS VSRQIEIRGL ESAVIYGSLP PGTKLAQAKK FNDPNDPCKI
   421  LVATDAIGMG LNLSIRRIIF YSLIKPSINE KGERELEPIT TSQALQIAGR AGRFSSRFKE
   481  GEVTTMNHED LSLLKEILKR PVDPIRAAGL HPTAEQIEMF AYHLPDATLS NLIDIFVDFS
   541  QVDGQYFVCN MDDFKFSAEL IQHIPLSLRV RYVFCTAPIN KKQPFVCSSL LQFARQYSRN
   601  EPLTFAWLRR YIKWPLLPPK NIKDLMDLEA VHDVLDLYLW LSYRFMDMFP DASLIRDLQK
   661  ELDGIIQDGV HNITKLIKMS ETHKLLNLEG FPSGSQSRLS GTLKSQARRT RGTKALGSKA
   721  TEPPSPDAGE LSLASRLVQQ GLLTPDMLKQ LEKEWMTQQT EHNKEKTESG THPKGTRRKK
   781  KEPDSD

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SUPV3L1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.33

Highest tissue expression

27 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.46

gnomAD pLI

0.03

gnomAD missense Z

1.15

DepMap mean gene effect

-0.91

DepMap dependency class

common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• DNA recombination
• mitochondrial mRNA catabolic process
• mitochondrial RNA 3'-end processing
• mitochondrial RNA catabolic process
• mitochondrial RNA surveillance
• mitochondrion organization
• negative regulation of apoptotic process
• positive regulation of cell growth
• positive regulation of mitochondrial RNA catabolic process
• RNA catabolic process
• mitochondrial mRNA surveillance
• mitochondrial ncRNA surveillance

Molecular functions

• 3'-5' RNA helicase activity
• ATP binding
• ATP hydrolysis activity
• DNA binding
• DNA helicase activity
• double-stranded RNA binding
• helicase activity
• identical protein binding
• protein homodimerization activity
• RNA binding
• RNA helicase activity

Cellular components

• mitochondrial degradosome
• mitochondrial matrix
• mitochondrial nucleoid
• mitochondrion
• nucleus

Protein domainsUniProt · Pfam · InterPro

• Helicase, C-terminal domain-like
• P-loop containing nucleoside triphosphate hydrolase
• ATP-dependent RNA helicase SUPV3-like
• Helicase conserved C-terminal domain
• ATP-dependent RNA helicase SUV3, C-terminal domain
• Suv3, C-terminal domain 1
• Suv3, N-terminal
• Suv3, DEXQ-box helicase domain
• ATP-dependent RNA helicase SUV3, DEXQ-box helicase domain
• ATP-dependent RNA helicase SUV3 C-terminal domain
• Suv3 helical N-terminal domain
• Suv3 C-terminal domain 1
• DEXQ-box helicase domain of Suv3

KeywordsUniProt

• Acetylation
• ATP-binding
• Helicase
• Hydrolase
• Mitochondrion
• Mitochondrion nucleoid
• Nucleotide-binding
• Nucleus
• Phosphoprotein
• Transit peptide

InteractionsUniProt · HPA

Protein binding partners of SUPV3L1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• BLM
• GRSF1
• WRN
• LAMTOR5