Seroatlas · Human Serome Atlas

KIF1C

Kinesin-like protein KIF1C

Also known as: KIF1C_HUMAN, SAX2, SPAX2, SPG58

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
O43896
Gene
KIF1C
Ensembl
ENSG00000129250
Chromosome
17
Canonical length
1103 aa
Protein class
Disease related genes, Human disease related genes, Plasma proteins, Predicted intracellular proteins
Subcellular location
Nucleoplasm,Nucleoli,Principal piece

OverviewNCBI Gene

The protein encoded by this gene is a member of the kinesin-like protein family. The family members are microtubule-dependent molecular motors that transport organelles within cells and move chromosomes during cell division. Mutations in this gene are a cause of spastic ataxia 2, autosomal recessive. [provided by RefSeq, May 2014]

Canonical amino-acid sequenceUniProt

1103 residues, UniProt reviewed canonical sequence.

>O43896|KIF1C
     1  MAGASVKVAV RVRPFNARET SQDAKCVVSM QGNTTSIINP KQSKDAPKSF TFDYSYWSHT
    61  STEDPQFASQ QQVYRDIGEE MLLHAFEGYN VCIFAYGQTG AGKSYTMMGR QEPGQQGIVP
   121  QLCEDLFSRV SENQSAQLSY SVEVSYMEIY CERVRDLLNP KSRGSLRVRE HPILGPYVQD
   181  LSKLAVTSYA DIADLMDCGN KARTVAATNM NETSSRSHAV FTIVFTQRCH DQLTGLDSEK
   241  VSKISLVDLA GSERADSSGA RGMRLKEGAN INKSLTTLGK VISALADMQS KKRKSDFIPY
   301  RDSVLTWLLK ENLGGNSRTA MIAALSPADI NYEETLSTLR YADRTKQIRC NAIINEDPNA
   361  RLIRELQEEV ARLRELLMAQ GLSASALEGL KTEEGSVRGA LPAVSSPPAP VSPSSPTTHN
   421  GELEPSFSPN TESQIGPEEA MERLQETEKI IAELNETWEE KLRKTEALRM EREALLAEMG
   481  VAVREDGGTV GVFSPKKTPH LVNLNEDPLM SECLLYHIKD GVTRVGQVDM DIKLTGQFIR
   541  EQHCLFRSIP QPDGEVVVTL EPCEGAETYV NGKLVTEPLV LKSGNRIVMG KNHVFRFNHP
   601  EQARLERERG VPPPPGPPSE PVDWNFAQKE LLEQQGIDIK LEMEKRLQDL ENQYRKEKEE
   661  ADLLLEQQRL YADSDSGDDS DKRSCEESWR LISSLREQLP PTTVQTIVKR CGLPSSGKRR
   721  APRRVYQIPQ RRRLQGKDPR WATMADLKMQ AVKEICYEVA LADFRHGRAE IEALAALKMR
   781  ELCRTYGKPD GPGDAWRAVA RDVWDTVGEE EGGGAGSGGG SEEGARGAEV EDLRAHIDKL
   841  TGILQEVKLQ NSSKDRELQA LRDRMLRMER VIPLAQDHED ENEEGGEVPW APPEGSEAAE
   901  EAAPSDRMPS ARPPSPPLSS WERVSRLMEE DPAFRRGRLR WLKQEQLRLQ GLQGSGGRGG
   961  GLRRPPARFV PPHDCKLRFP FKSNPQHRES WPGMGSGEAP TPLQPPEEVT PHPATPARRP
  1021  PSPRRSHHPR RNSLDGGGRS RGAGSAQPEP QHFQPKKHNS YPQPPQPYPA QRPPGPRYPP
  1081  YTTPPRMRRQ RSAPDLKESG AAV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against KIF1C can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.44
Highest tissue expression
526 nTPM

Expression across tissuesHPA

Tissue

  • skeletal muscle: 526 nTPM
  • tongue: 363 nTPM
  • spinal cord: 255 nTPM
  • midbrain: 208 nTPM
  • heart muscle: 165 nTPM
  • hippocampal formation: 156 nTPM

Single-cell type

  • esophageal apical cells: 328 nCPM
  • colonocytes: 140 nCPM
  • thymic myoid cells: 103 nCPM
  • esophageal suprabasal cells: 99 nCPM
  • hepatocytes: 96 nCPM
  • goblet cells: 90 nCPM

Immune cell

  • neutrophil: 1.1 nTPM
  • eosinophil: 0.7 nTPM
  • basophil: 0.5 nTPM
  • classical monocyte: 0.4 nTPM
  • intermediate monocyte: 0.4 nTPM
  • memory B-cell: 0.4 nTPM

Brain region

  • white matter: 286 nTPM
  • basal ganglia: 259 nTPM
  • midbrain: 231 nTPM
  • medulla oblongata: 231 nTPM
  • spinal cord: 202 nTPM
  • thalamus: 198 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about KIF1C.

Disease | AllUniProt

Conditions KIF1C is implicated in, by any mechanism.

  • Spastic ataxia 2, autosomal recessive (SPAX2) MIM:611302

Disease | GeneticClinVar

38 pathogenic / likely-pathogenic of 804 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.34
gnomAD pLI
0.72
gnomAD missense Z
1.4
DepMap mean gene effect
-0.05
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of KIF1C in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads KIF1C as an antibody target. Whether an autoantibody or antibody against KIF1C could matter depends on whether native KIF1C is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

KIF1C is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label KIF1C as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/KIF1C. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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