KIFC2

Protein identityUniProt · HPA

UniProt accession

Q96AC6

Gene

KIFC2

Ensembl

ENSG00000167702

Chromosome

8

Canonical length

838 aa

Protein class

Predicted intracellular proteins

Subcellular location

Nucleoplasm,Cytosol

OverviewNCBI Gene

Predicted to enable ATP hydrolysis activity; microtubule binding activity; and plus-end-directed microtubule motor activity. Predicted to be involved in anterograde dendritic transport of neurotransmitter receptor complex; axon guidance; and synaptic vesicle transport. Predicted to be located in cytoskeleton and dendrite cytoplasm. Predicted to be part of kinesin complex. Predicted to be active in cytoplasm and microtubule. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

838 residues, UniProt reviewed canonical sequence.

>Q96AC6|KIFC2
     1  MYAFYSLLIY IFYSLFRRDG GAAAAAEPGD PAQRARKPRG RRRPDLPAPE LWTELTGLAA
    61  SSEPEDGSEG AAEGRAAAVS LEEALLRLAE FLSVQLGAEE SCGGPADLGQ SGEVPSLLTV
   121  TSQLLALLAW LRSPRGRQAL LQGTQPAPRV RPPSPDGSTS QEESPSHFTA VPGEPLGDET
   181  QGQQPLQLEE DQRAWQRLEQ LILGQLEELK QQLEQQEEEL GRLRLGVGAT DSEKRVQHLT
   241  LENEALKQSL SLMRDLLLHW GPGPPIRAPQ EEAEALLELQ GRLQEAQDTT EALRAQLGVQ
   301  EVQLQGLQGA LQQLQQETEQ NCRRELQQMH GQLAGLRARM ASLRQGCGDL RGLVSTFTQS
   361  CQGSLSEARG QVSWALGALS SGGPGTQLPE GQQGPPAGCP GRLPELKGNI RVLCRLRPGT
   421  SSSLVSVEPG PGGTVTTCYR GRHRRFRLDW VFPPDASQEE VFRELEPAVL SCLRGYSVCI
   481  FTYGQTGTGK TYSMEGPPED PGIVPRALQS LFREMGAGRQ HRVTLSMVEI YNEAVRDLLA
   541  PGPPERLAVR QGPEGQGGIQ VAGLTHWDVP NLETLHQMLK LGRSNRATAA TAMNQRSSRS
   601  HALVTLTLRA ASPPRAPGTA GTLHLVDLAG SERARKAGAA GPPRGDPDGA RRLREAQTIN
   661  RSLLALGGVM AALRAHRPHV PFRDSQLTRL LQPALGPGTT AVLLLQVGAG AGQVCACRSP
   721  PTRARPPAPL ARRSPRGRRI SGRQSAPSSS PTEWVKWSWG QPGAAGSRAP PGRLLPSAPT
   781  LRSPGPPAPL RRPLAVLHAP VPTTARARLS RPQRACPSSP GSRPCPWGLR PGLCWQRR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against KIFC2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.48

Highest tissue expression

215 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.83

gnomAD pLI

0

gnomAD missense Z

-1.41

DepMap mean gene effect

-0.04

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 10% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• anterograde dendritic transport of neurotransmitter receptor complex
• axon guidance
• synaptic vesicle transport

Molecular functions

• ATP binding
• ATP hydrolysis activity
• microtubule binding
• plus-end-directed microtubule motor activity

Cellular components

• cytoplasm
• dendrite cytoplasm
• kinesin complex
• microtubule

Protein domainsUniProt · Pfam · InterPro

• Kinesin motor domain
• Kinesin motor domain, conserved site
• P-loop containing nucleoside triphosphate hydrolase
• Kinesin-like protein
• Kinesin motor domain superfamily
• Kinesin motor domain

KeywordsUniProt

• ATP-binding
• Coiled coil
• Cytoplasm
• Cytoskeleton
• Microtubule
• Motor protein
• Nucleotide-binding

InteractionsUniProt · HPA

Protein binding partners of KIFC2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• BICD1